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Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis

  • Authors:
    • Shengjian Fang
    • Xinqian Li
    • Xian Wei
    • Yu Zhang
    • Zhaoxin Ma
    • Youzhen Wei
    • Weihua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China
    Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5178-5184
    |
    Published online on: October 19, 2018
       https://doi.org/10.3892/etm.2018.6880
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Abstract

Allergic rhinitis (AR) is a common chronic inflammatory condition. It has been previously indicated that oxidative stress may contribute to allergic inflammation, including AR. Although molecular hydrogen (H2), an antioxidative agent, has been effective in treatment of numerous oxidative stress‑associated diseases, the effect of inhalation of a high concentration of H2 on AR remains unknown. In the current study, female BALB/c mice were sensitized with ovalbumin (OVA) followed by intranasal OVA challenge to establish an animal model of AR. Mice were subjected to exposure to H2 and the inert gas helium at different frequencies and durations. The frequencies of sneezing/scratching and the body weights of mice were recorded. Histological analysis and multiplex cytokine assays were performed to evaluate the effects of H2 on AR. Challenge with OVA induced significant nasal mucosa inflammation. H2 inhalation reduced the infiltration of inflammatory cells into mucosa and lowered the levels of interleukin (IL)‑5, IL‑13 and monocyte chemoattractant protein‑1 in serum. H2 inhalation slightly increased the level of interferon‑γ, however the difference was not statistically significant. Treatment with H2 limited the weight increase in healthy mice and reversed the weight loss in mice with AR. Furthermore, H2 inhalation induced a therapeutic effect on AR in a dose‑dependent manner. The current results demonstrate that H2 may demonstrate a therapeutic value for allergic diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Fang S, Li X, Wei X, Zhang Y, Ma Z, Wei Y and Wang W: Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis. Exp Ther Med 16: 5178-5184, 2018.
APA
Fang, S., Li, X., Wei, X., Zhang, Y., Ma, Z., Wei, Y., & Wang, W. (2018). Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis. Experimental and Therapeutic Medicine, 16, 5178-5184. https://doi.org/10.3892/etm.2018.6880
MLA
Fang, S., Li, X., Wei, X., Zhang, Y., Ma, Z., Wei, Y., Wang, W."Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 16.6 (2018): 5178-5184.
Chicago
Fang, S., Li, X., Wei, X., Zhang, Y., Ma, Z., Wei, Y., Wang, W."Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5178-5184. https://doi.org/10.3892/etm.2018.6880
Copy and paste a formatted citation
x
Spandidos Publications style
Fang S, Li X, Wei X, Zhang Y, Ma Z, Wei Y and Wang W: Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis. Exp Ther Med 16: 5178-5184, 2018.
APA
Fang, S., Li, X., Wei, X., Zhang, Y., Ma, Z., Wei, Y., & Wang, W. (2018). Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis. Experimental and Therapeutic Medicine, 16, 5178-5184. https://doi.org/10.3892/etm.2018.6880
MLA
Fang, S., Li, X., Wei, X., Zhang, Y., Ma, Z., Wei, Y., Wang, W."Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 16.6 (2018): 5178-5184.
Chicago
Fang, S., Li, X., Wei, X., Zhang, Y., Ma, Z., Wei, Y., Wang, W."Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5178-5184. https://doi.org/10.3892/etm.2018.6880
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