Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children

Li,Chunxiang; Zhu,Limin; Gong,Xiaolei; Xu,Zhuoming; Liu,Yujie; Zhang,Mingjie; Cao,Qing

doi:10.3892/etm.2018.6905

Soluble triggering receptor expressed on myeloid cells‑1 as a useful biomarker for diagnosing ventilator‑associated pneumonia after congenital cardiac surgery in children

Authors:
- Chunxiang Li
- Limin Zhu
- Xiaolei Gong
- Zhuoming Xu
- Yujie Liu
- Mingjie Zhang
- Qing Cao
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Affiliations: Department of Cardiac Intensive Care Unit, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China, Department of Infectious Disease, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China
Published online on: October 31, 2018 https://doi.org/10.3892/etm.2018.6905
Pages: 147-152
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to assess the usefulness of soluble triggering receptor expressed on myeloid cells 1 (sTREM‑1) in the diagnosis of ventilator‑associated pneumonia (VAP) in paediatric patients with congenital heart disease (CHD) following cardiac surgery. The current prospective study enrolled 48 patients with congenital heart diseases who were suspected of having VAP; these patients were undergoing cardiac surgery between August 2016 and October 2017 in the Cardiac Intensive Care Unit of Shanghai Children's Medical Center (Shanghai, China). A total of 31 patients were diagnosed with VAP using a polymerase chain reaction (PCR) assay, while 17 patients without VAP were designated as the Non‑VAP group. A bronchoscopy was performed and samples were collected for measurement on the day that VAP was diagnosed. The sTREM‑1 levels were measured in bronchoalveolar lavage fluid (BALF) and exhaled ventilator condensate (EVC). BALF specimens were also sent to the microbiology laboratory for PCR assays and quantitative culturing. The positive detection rate of bacteria using the PCR assay and traditional culture was 64.6% (31/48) and 39.6% (19/48). sTREM‑1 was significantly higher in the BALF (146.21 pg/ml vs. 118.06 pg/ml) and EVC (125.29 pg/ml vs. 120.48 pg/ml) of patients with VAP demonstrated compared with the patients without VAP. The findings suggest that the detection of sTREM‑1 in BALF and EVC samples may be useful for the diagnosis of VAP following heart surgery in children.

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