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Correlation of clinical features with hs‑CRP in TRD patients

  • Authors:
    • Juan Qiao
    • Deqin Geng
    • Liju Qian
    • Xianghua Zhu
    • Houfeng Zhao

  • View Affiliations

  • Published online on: November 1, 2018     https://doi.org/10.3892/etm.2018.6914
  • Pages: 344-348

  • Copyright: © Qiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Correlation of clinical features with hypersensitive C‑reactive protein (hs‑CRP) in patients with treatment‑resistant depression (TRD) was investigated. The severity of disease in 103 TRD patients and 103 non‑TRD patients was evaluated using the Hamilton Depression Scale (HAMD)‑17. The levels of hs‑CRP in both groups were detected via immunofluorescence. Clinical features and differences in hs‑CRP before and after treatment in both groups were analyzed, and correlation of baseline hs‑CRP level with clinical features of TRD patients was also analyzed. Moreover, the relationship between hs‑CRP and occurrence of TRD was analyzed using logistic regression analysis, and the diagnostic value of hs‑CRP in TRD was evaluated using the receiver operating characteristic (ROC) curve. The onset age in the TRD group was lower than that in the non‑TRD group, the education in the TRD group was shorter than that in the non‑TRD group, the total course of disease in the TRD group was longer than that in the non‑TRD group, and both baseline and post‑treatment hs‑CRP level in the TRD group (12.05±5.79 and 9.02±3.71 mg/l) were higher than those in the non‑TRD group (7.85±2.85 and 6.10±2.74 mg/l) (p<0.05). The HAMD score (r=0.338, p=0.031), anxiety/somatization factor score (r=0.465, p=0.015) and sleep disorder (r=0.387, p=0.029) of TRD patients were positively correlated with the hs‑CRP level, but the onset age (r=‑0.59, p=0.009) was negatively correlated with the hs‑CRP level. Logistic regression analysis revealed that the baseline hs‑CRP was included into the TRD regression equation [odds ratio (OR) =2.834, 95% confidence interval (CI) =1.723‑4.886], and the area under the ROC curve was 0.893 (p<0.05, 95% CI=0.852‑0.933). In the TRD group, the course of TRD in patients was longer, the onset of disease was earlier and the educational level was lower than that in the non‑TRD group. Therefore, the level of hs‑CRP can serve as a reference for the diagnosis of TRD.
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Spandidos Publications style
Qiao J, Geng D, Qian L, Zhu X and Zhao H: Correlation of clinical features with hs‑CRP in TRD patients . Exp Ther Med 17: 344-348, 2019.
APA
Qiao, J., Geng, D., Qian, L., Zhu, X., & Zhao, H. (2019). Correlation of clinical features with hs‑CRP in TRD patients . Experimental and Therapeutic Medicine, 17, 344-348. https://doi.org/10.3892/etm.2018.6914
MLA
Qiao, J., Geng, D., Qian, L., Zhu, X., Zhao, H."Correlation of clinical features with hs‑CRP in TRD patients ". Experimental and Therapeutic Medicine 17.1 (2019): 344-348.
Chicago
Qiao, J., Geng, D., Qian, L., Zhu, X., Zhao, H."Correlation of clinical features with hs‑CRP in TRD patients ". Experimental and Therapeutic Medicine 17, no. 1 (2019): 344-348. https://doi.org/10.3892/etm.2018.6914