New insights in vitiligo treatments using bioactive compounds from Piper nigrum

Mihăilă,Bianca; Dinică,Rodica   Mihaela; Tatu,Alin   Laurențiu; Buzia,Olimpia   Dumitriu

doi:10.3892/etm.2018.6977

New insights in vitiligo treatments using bioactive compounds from Piper nigrum

Authors:
- Bianca Mihăilă
- Rodica Mihaela Dinică
- Alin Laurențiu Tatu
- Olimpia Dumitriu Buzia
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Affiliations: SC Ecofarmacia Network SRL, 550253 Sibiu, Romania, Department of Chemistry, Faculty of Sciences and Environment, ‘Dunărea de Jos’ University of Galați, 800201 Galați, Romania, Medical and Pharmaceutical Research Unit/Competitive, Interdisciplinary Research Integrated Platform ‘Dunărea de Jos’, ReForm-UDJG; ‘Research Centre in the Field of Medical and Pharmaceutical Sciences’, Faculty of Medicine, Department of Pharmacy/Pharmacology Sciences, ‘Dunărea de Jos’ University of Galați, Galați 800101, Romania, Medical and Pharmaceutical Research Unit, ‘Research Centre in the Field of Medical and Pharmaceutical Sciences’, Faculty of Medicine, Department of Pharmacy/Pharmacology Sciences, ‘Dunărea de Jos’ University of Galați, Galați 800101, Romania
Published online on: November 16, 2018 https://doi.org/10.3892/etm.2018.6977
Pages: 1039-1044
Copyright: © Mihăilă et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although vitiligo is one of the most frequently occurring depigmentary disorder, its pathophysiology is still not fully clarified, resulting in the incapacity to find a targeted cure. Most of the treatment options available at the time have an anti-inflammatory or immunosuppressive effect, influencing the immune factor in vitiligo but without having a direct effect on melanocyte differentiation, migration or proliferation. This study shows that Piper nigrum (PN) extract and its main alkaloid, piperine, promote melanocyte proliferation in vivo, being consistent with previous study. A PN fruit extract and pure piperine were integrated in two different ointments and tested on human subjects affected by vitiligo. A number of 9 areas were treated: 3 using the extract, 3 using pure piperine, 1 using travoprost solution, and 2 using an association of travoprost (prostaglandin F2α analogue) solution and our products. Pigmentation was achieved in all the treated areas. The extract caused faster and more remarkable results than the pure piperine. The association of the travoprost solution speed up the process and changed the pigmentation pattern, especially when associated with the PN extract. Our early studies suggest that PN extract may represent, in the future, a new treatment option for vitiligo, especially considering the mild side effects of the tested products and the reduced amount of time needed for repigmentation. However, more studies are needed to validate this experimental data.

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