Sea buckthorn extract in the treatment of psoriasis

Boca,Andreea   Nicoleta; Ilies,Roxana   Flavia; Saccomanno,Jacopo; Pop,Raluca; Vesa,Stefan; Tataru,Alexandru   Dumitru; Buzoianu,Anca   Dana

doi:10.3892/etm.2018.6983

Sea buckthorn extract in the treatment of psoriasis

Authors:
- Andreea Nicoleta Boca
- Roxana Flavia Ilies
- Jacopo Saccomanno
- Raluca Pop
- Stefan Vesa
- Alexandru Dumitru Tataru
- Anca Dana Buzoianu
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Affiliations: Department of Pharmacology, Toxicology and Clinical Pharmacology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400337 Cluj‑Napoca, Romania, Faculty of Medicine, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Dermatology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400000 Cluj‑Napoca, Romania
Published online on: November 16, 2018 https://doi.org/10.3892/etm.2018.6983
Pages: 1020-1023

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Abstract

Psoriasis is one of the most common chronic dermatological conditions, with a strong impact on patients' quality of life. Currently, psoriasis benefits from conventional therapy with a high rate of adverse effects and an increase in non‑compliance and self‑medication of patients. As such, there is a need to pinpoint low‑adverse effects and accessible remedies for this condition. Our single‑blind, placebo‑controlled study assessed the effect of sea buckthorn extract on psoriasis lesions in previously untreated patients. Our results showed an improvement in Psoriasis Area Severity Index (PASI) scores and in Dermatology Life Quality Index (DLQI) scores when compared to the baseline values, as well as at the 4‑ and 8‑week time marks for the lesions treated with sea buckthorn extract. By contrast, the measurements for the placebo treated lesions showed no alteration at the 4‑week mark, and significant worsening at the end of the trial. These findings provide a solid, optimistic base for the in‑depth research of sea buckthorn as an adjuvant or a component in psoriasis care protocols.

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