Significance and impact of dietary factors on systemic lupus erythematosus pathogenesis (Review)

Constantin,Maria‑Magdalena; Nita,Iuliana   Elena; Olteanu,Rodica; Constantin,Traian; Bucur,Stefana; Matei,Clara; Raducan,Anca

doi:10.3892/etm.2018.6986

Significance and impact of dietary factors on systemic lupus erythematosus pathogenesis (Review)

Authors:
- Maria‑Magdalena Constantin
- Iuliana Elena Nita
- Rodica Olteanu
- Traian Constantin
- Stefana Bucur
- Clara Matei
- Anca Raducan
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Affiliations: University of Medicine and Pharmacy ‘Carol Davila̓, 050474 Bucharest, Romania, The Second Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania , Dr. Anca Răducan Anti‑Aging Dermatology Clinic, 900162 Constanta, Romania
Published online on: November 16, 2018 https://doi.org/10.3892/etm.2018.6986
Pages: 1085-1090

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology, although its mechanisms involve genetic, epigenetic and environmental risk factors. Considering that SLE pathogenesis is yet to be explored, recent studies aimed to investigate the impact of diet, in terms of triggering or altering the course of the disease. To study the impact of diet on SLE pathogenesis, we conducted a search on Pubmed using the keywords ‘diet and autoimmune diseases’, ‘diet and lupus’, ‘caloric restriction and lupus’, ‘polyunsaturated fatty acids and lupus’, ‘vitamin D and lupus’, ‘vitamin C and lupus’ ‘vitamin E and lupus’ ‘vitamin A and lupus’ ‘vitamin B and lupus’, ‘polyphenols and lupus’, ‘isoflavones and lupus’, ‘minerals and lupus’, ‘aminoacids and lupus’, ‘curcumin and lupus’ and found 10,215 papers, from which we selected 47 relevant articles. The paper clearly emphasizes the beneficial role of personalized diet in patients with SLE, and the information presented could be used in daily practice. Proper diet in SLE can help preserve the body's homeostasis, increase the period of remission, prevent adverse effects of medication and improve the patient's physical and mental well‑being.

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