Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

  • Authors:
    • Ilinca Nicolae
    • Mircea Tampa
    • Corina Daniela Ene
    • Cristina Iulia Mitran
    • Madalina Irina Mitran
    • Maria Isabela Sarbu
    • Clara Matei
    • Cosmin Ene
    • Simona Roxana Georgescu
  • View Affiliations

  • Published online on: December 5, 2018     https://doi.org/10.3892/etm.2018.7053
  • Pages: 1012-1019
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Abstract

Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=-0.301 and P=0.036, r=-0.384 and P=0.002). Thus, severe psoriasis is a risk factor for the development of renal disease.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Nicolae I, Tampa M, Ene CD, Mitran CI, Mitran MI, Sarbu MI, Matei C, Ene C and Georgescu SR: Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris. Exp Ther Med 17: 1012-1019, 2019.
APA
Nicolae, I., Tampa, M., Ene, C.D., Mitran, C.I., Mitran, M.I., Sarbu, M.I. ... Georgescu, S.R. (2019). Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris. Experimental and Therapeutic Medicine, 17, 1012-1019. https://doi.org/10.3892/etm.2018.7053
MLA
Nicolae, I., Tampa, M., Ene, C. D., Mitran, C. I., Mitran, M. I., Sarbu, M. I., Matei, C., Ene, C., Georgescu, S. R."Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris". Experimental and Therapeutic Medicine 17.2 (2019): 1012-1019.
Chicago
Nicolae, I., Tampa, M., Ene, C. D., Mitran, C. I., Mitran, M. I., Sarbu, M. I., Matei, C., Ene, C., Georgescu, S. R."Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1012-1019. https://doi.org/10.3892/etm.2018.7053