miR‑34a alleviates spinal cord injury via TLR4 signaling by inhibiting HMGB‑1

  • Authors:
    • Jianmin Zhou
    • Ou Shuang
    • Jian Li
    • Zijun Cai
    • Chong Wu
    • Wenyu Wang
  • View Affiliations

  • Published online on: December 17, 2018     https://doi.org/10.3892/etm.2018.7102
  • Pages: 1912-1918
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Abstract

The aim of the present study was to investigate the effect of microRNA (miR)‑34a on spinal cord injury (SCI)‑induced inflammation and the possible underlying mechanisms. The results indicated that miR‑34a expression was downregulated in a rat model of SCI compared with the control group. Furthermore, miR‑34a knockdown was demonstrated to aggravate inflammation, inhibit cell proliferation and enhance apoptosis in an in vitro model of SCI. MiR‑34a inhibition was demonstrated to upregulate the expression of inducible nitric oxide synthase and nitric oxide, as well as inducing the expression of toll‑like receptor 4 (TLR4) and high mobility group box‑1 (HMGB‑1) in an in vitro model of SCI. TLR4 inhibitor reduced the effects of miR‑34a downregulation on inflammation and cell growth in SCI. Together, these results suggest that miR‑34a is able to alleviate SCI via inhibiting HMGB‑1 expression in TLR4 signaling.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou J, Shuang O, Li J, Cai Z, Wu C and Wang W: miR‑34a alleviates spinal cord injury via TLR4 signaling by inhibiting HMGB‑1. Exp Ther Med 17: 1912-1918, 2019.
APA
Zhou, J., Shuang, O., Li, J., Cai, Z., Wu, C., & Wang, W. (2019). miR‑34a alleviates spinal cord injury via TLR4 signaling by inhibiting HMGB‑1. Experimental and Therapeutic Medicine, 17, 1912-1918. https://doi.org/10.3892/etm.2018.7102
MLA
Zhou, J., Shuang, O., Li, J., Cai, Z., Wu, C., Wang, W."miR‑34a alleviates spinal cord injury via TLR4 signaling by inhibiting HMGB‑1". Experimental and Therapeutic Medicine 17.3 (2019): 1912-1918.
Chicago
Zhou, J., Shuang, O., Li, J., Cai, Z., Wu, C., Wang, W."miR‑34a alleviates spinal cord injury via TLR4 signaling by inhibiting HMGB‑1". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1912-1918. https://doi.org/10.3892/etm.2018.7102