Inflammatory cytokines tumor necrosis factor‑α, interleukin‑8 and sleep monitoring in patients with obstructive sleep apnea syndrome

Ming,Hao; Tian,Aimin; Liu,Bing; Hu,Yuqiang; Liu,Chen; Chen,Renjie; Cheng,Liangjun

doi:10.3892/etm.2018.7110

Inflammatory cytokines tumor necrosis factor‑α, interleukin‑8 and sleep monitoring in patients with obstructive sleep apnea syndrome

Authors:
- Hao Ming
- Aimin Tian
- Bing Liu
- Yuqiang Hu
- Chen Liu
- Renjie Chen
- Liangjun Cheng
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Affiliations: Department of Otolaryngology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Otolaryngology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China
Published online on: December 18, 2018 https://doi.org/10.3892/etm.2018.7110
Pages: 1766-1770

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Abstract

The present study investigated the changes of tumor necrosis factor‑α (TNF‑α), interleukin‑8 (IL‑8) and sleep ability in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). A total of 684 patients who were admitted to Xuzhou Central Hospital between June 2012 and June 2016 were enrolled to serve as the experimental group and 192 healthy subjects were selected as the control group. Polysomnography was performed on both groups, and serum TNF‑α and IL‑8 levels were measured by ELISA. Pearson's correlation analysis was used to analyze correlations between factors. Compared with control group, the levels of TNF‑α and IL‑8, the morning systolic and diastolic pressure in OSAHS group were significantly higher (P<0.01). Furthermore, the mean oxygen saturation (MSaO2) and lowest oxygen saturation (LSaO2) of the OSAHS group were significantly lower compared with those in control group (P<0.01). Results also indicated that TNF‑α was positively correlated with apnea‑hypopnea index (AHI), morning systolic and diastolic pressure (r=0.621, 0.464, 0.539; P<0.05), and negatively correlated with MSaO2 and LSaO2 (r=‑0.526, ‑0.466; P<0.05). Notably, IL‑8 was positively correlated with AHI, morning systolic and diastolic pressure (r=0.337, 0.413 and 0.629; P<0.05), and negatively correlated with MSaO2 and LSaO2 (r=‑0.329 and ‑0.417; P<0.05). Therefore, it was concluded that TNF‑α and IL‑8 may be involved in the occurrence and development of OSAHS, are closely related to OSAHS and may be important risk factors for cardiovascular disease in patients with OSAHS. The present findings suggest that TNF‑α and IL‑8 can be used to assess the degree of OSAHS.

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