Open Access

Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition

  • Authors:
    • Zhuying Yang
    • Qigui Xie
    • Zhanlei Chen
    • Haibin Ni
    • Liang Xia
    • Qiufeng Zhao
    • Zhiyun Chen
    • Peifeng Chen
  • View Affiliations

  • Published online on: December 28, 2018     https://doi.org/10.3892/etm.2018.7142
  • Pages: 1569-1578
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Resveratrol, a natural polyphenolic phytoalexin, was reported to exert multiple anticancer effects as a traditional Chinese medicine. However, research regarding the anticancer mechanism of resveratrol for the treatment and prevention of gastric cancer has reported conflicting results. In the present study, it was determined that resveratrol inhibited cell viability in a dose‑dependent manner in the human gastric cancer cell line BGC823. Cell migration and invasion were suppressed significantly following treatment with 200 µM resveratrol. Additionally, resveratrol inhibited metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) expression, which was overexpressed in gastric cancer cells. Further experiments revealed that MALAT1 knockdown suppressed cell viability, migration, invasion and epithelial‑to‑mesenchymal transition in BGC823 cells. The present study indicated that resveratrol inhibited migration and invasion in human gastric cancer cells via suppressing MALAT1‑mediated epithelial‑to‑mesenchymal transition, providing novel evidence for understanding the anticancer mechanism of resveratrol.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang Z, Xie Q, Chen Z, Ni H, Xia L, Zhao Q, Chen Z and Chen P: Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition. Exp Ther Med 17: 1569-1578, 2019.
APA
Yang, Z., Xie, Q., Chen, Z., Ni, H., Xia, L., Zhao, Q. ... Chen, P. (2019). Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition. Experimental and Therapeutic Medicine, 17, 1569-1578. https://doi.org/10.3892/etm.2018.7142
MLA
Yang, Z., Xie, Q., Chen, Z., Ni, H., Xia, L., Zhao, Q., Chen, Z., Chen, P."Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition". Experimental and Therapeutic Medicine 17.3 (2019): 1569-1578.
Chicago
Yang, Z., Xie, Q., Chen, Z., Ni, H., Xia, L., Zhao, Q., Chen, Z., Chen, P."Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1569-1578. https://doi.org/10.3892/etm.2018.7142