MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1

Hu,Xinde; Liu,Yifeng; Ai,Ping; He,Shuguang; Liu,Lingzhi; Chen,Chaoying; Tan,Yuansheng; Wang,Ting

doi:10.3892/etm.2019.7154

MicroRNA‑186 promotes cell proliferation and inhibits cell apoptosis in cutaneous squamous cell carcinoma by targeting RETREG1

Authors:
- Xinde Hu
- Yifeng Liu
- Ping Ai
- Shuguang He
- Lingzhi Liu
- Chaoying Chen
- Yuansheng Tan
- Ting Wang
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Affiliations: Clinical Laboratory, Second People's Hospital of Shaoyang City, Shaoyang, Hunan 422000, P.R. China, Department of Dermatology, Second People's Hospital of Shaoyang City, Shaoyang, Hunan 422000, P.R. China, Department of General Surgery, Second People's Hospital of Shaoyang City, Shaoyang, Hunan 422000, P.R. China, Clinical Laboratory, First Affiliated Hospital of Hunan University of Chinese Medicine, Zhuzhou, Hunan 412000, P.R. China, Hanpu Science and Teaching Park, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China
Published online on: January 7, 2019 https://doi.org/10.3892/etm.2019.7154
Pages: 1930-1938

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Abstract

MicroRNAs (miRs), a class of small non‑coding RNAs, have been demonstrated to be involved in the development and progression of human malignancies, including cutaneous squamous cell carcinoma (CSCC). miR‑186 serves a suppressive role in certain common types of human cancer; however, its exact function in CSCC has not been reported previously. In the present study, the expression of miR‑186 was significantly increased in CSCC tissues compared with adjacent non‑tumour tissues. Overexpression of miR‑186 significantly promoted CSCC cell proliferation while inhibiting cell apoptosis. Reticulophagy regulator 1 (RETREG1), a gene that is significantly downregulated in CSCC tissues and cell lines, was identified as a novel target of miR‑186. In addition, the expression of RETREG1 was inversely correlated with miR‑186 expression in CSCC tissues. Furthermore, the expression of RETREG1 was negatively regulated by miR‑186 in CSCC cells, and restoration of RETREG1 attenuated the effects of miR‑186 on CSCC cells. Taken together, the results of the current study suggest that miR‑186 serves an oncogenic role in CSCC and may be used as a potential therapeutic target for the treatment of this disease.

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