Changes in oxidative stress levels during two weeks of smoking cessation treatment and their association with nutritional characteristics in Japanese smokers

Oba,Shino; Inaba,Yohei; Shibuya,Tomoyuki; Oshima,Joji; Seyama,Kuniaki; Kobayashi,Toshihiro; Kunugita,Naoki; Ino,Toshihiro

doi:10.3892/etm.2019.7252

Changes in oxidative stress levels during two weeks of smoking cessation treatment and their association with nutritional characteristics in Japanese smokers

Authors:
- Shino Oba
- Yohei Inaba
- Tomoyuki Shibuya
- Joji Oshima
- Kuniaki Seyama
- Toshihiro Kobayashi
- Naoki Kunugita
- Toshihiro Ino
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Affiliations: Graduate School of Health Sciences, Gunma University, Maebashi, Gunma 371‑8514, Japan, Department of Environmental Health, National Institute of Public Health, Wako, Saitama 351‑0197, Japan, Shibuya Clinic, Kumagaya, Saitama 360‑0812, Japan, Kubojima Clinic, Kumagaya, Saitama 360‑0831, Japan, Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Bunkyo‑Ku, Tokyo 113‑8431, Japan, Kobayashi Pediatric Clinic, Kumagaya, Saitama 360‑0204, Japan, Faculty of Health Science, Gunma Paz University, Takasaki, Gunma 370‑0006, Japan
Published online on: February 7, 2019 https://doi.org/10.3892/etm.2019.7252
Pages: 2757-2764
Copyright: © Oba et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although several experimental studies have reported that oxidative stress levels decrease during smoking cessation, how they change among general smokers has yet to be completely elucidated. In the present study, a total of 23 smokers who underwent smoking cessation treatment were observed for two‑week changes in their levels of 8‑OHdG and 8‑isoprostane. Physical and nutritional characteristics were measured at the initial patient visit, and casual urine samples were collected at the initial visit and at a follow‑up visit two weeks later. Oxidative stress was measured by a high performance liquid chromatography electrochemical detector, and the two‑week difference in the levels of oxidative stress was assessed according to demographic and nutrient factors. Neither the urinary level of 8‑OHdG nor that of 8‑isoprostane decreased, although the cotinine level was decreased at two weeks. A Two‑way repeated ANOVA revealed a significant interaction for fat intake by time for the change in the 8‑OHdG level (P=0.03) and significant interactions for α‑tocopherol intake (P=0.03), iron intake, and carbohydrate intake (P=0.03), all of which were time‑dependent for the change in the 8‑isoprostane level. The 8‑OHdG level decreased among smokers with a high fat intake and was increased with a low fat intake. The 8‑isoprostane levels were decreased among smokers with a high carbohydrate intake and increased with a low carbohydrate intake, decreased with a low iron intake and increased with a high iron intake and decreased with a low α‑tocopherol intake and increased with a high α‑tocopherol intake. Although the present study failed to observe a decrease in oxidative stress levels during the two‑week smoking cessation period, we hypothesize that the intake levels of specific nutrients when initiating smoking cessation treatment may predict any subsequent changes in the oxidative stress levels.

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1	Harris KK, Zopey M and Friedman TC: Metabolic effects of smoking cessation. Nat Rev Endocrinol. 12:299–308. 2016. View Article : Google Scholar : PubMed/NCBI
2	Ikeda F, Ninomiya T, Doi Y, Hata J, Fukuhara M, Matsumoto T and Kiyohara Y: Smoking cessation improves mortality in Japanese men: The Hisayama study. Tob Control. 21:416–421. 2012. View Article : Google Scholar : PubMed/NCBI
3	Morita H, Ikeda H, Haramaki N, Eguchi H and Imaizumi T: Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers. J Am Coll Cardiol. 45:589–594. 2005. View Article : Google Scholar : PubMed/NCBI
4	Priemé H, Loft S, Klarlund M, Grønbaek K, Tønnesen P and Poulsen HE: Effect of smoking cessation on oxidative DNA modification estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion. Carcinogenesis. 19:347–351. 1998. View Article : Google Scholar : PubMed/NCBI
5	Loft S, Vistisen K, Ewertz M, Tjønneland A, Overvad K and Poulsen HE: Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: Influence of smoking, gender and body mass index. Carcinogenesis. 13:2241–2247. 1992. View Article : Google Scholar : PubMed/NCBI
6	Roberts LJ II and Morrow JD: Products of the isoprostane pathway: Unique bioactive compounds and markers of lipid peroxidation. Cell Mol Life Sci. 59:808–820. 2002. View Article : Google Scholar : PubMed/NCBI
7	Davi G, Falco A and Patrono C: Determinants of F₂-isoprostane biosynthesis and inhibition in man. Chem Phys Lipids. 128:149–163. 2004. View Article : Google Scholar : PubMed/NCBI
8	Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 330:1029–1035. 1994. View Article : Google Scholar : PubMed/NCBI
9	Cocate PG, Natali AJ, Oliveira Ad, Longo GZ, Alfenas Rde C, Peluzio Mdo C, Santos EC, Buthers JM, Oliveira LL and Hermsdorff HH: Fruit and vegetable intake and related nutrients are associated with oxidative stress markers in middle-aged men. Nutrition. 30:660–665. 2014. View Article : Google Scholar : PubMed/NCBI
10	Block G, Dietrich M, Norkus EP, Morrow JD, Hudes M, Caan B and Packer L: Factors associated with oxidative stress in human populations. Am J Epidemiol. 156:274–285. 2002. View Article : Google Scholar : PubMed/NCBI
11	Sakano N, Wang DH, Takahashi N, Wang B, Sauriasari R, Kanbara S, Sato Y, Takigawa T, Takaki J and Ogino K: Oxidative stress biomarkers and lifestyles in Japanese healthy people. J Clin Biochem Nutr. 44:185–195. 2009. View Article : Google Scholar : PubMed/NCBI
12	Mizoue T, Kasai H, Kubo T and Tokunaga S: Leanness, smoking, and enhanced oxidative DNA damage. Cancer Epidemiol Biomarkers Prev. 15:582–585. 2006. View Article : Google Scholar : PubMed/NCBI
13	The Japanese Circulation Society, the Japan Lung Cancer Society, Cancer Association the Japanese Respiratory Society: Smoking Cessation Treatment Guidelines. (6th). Tokyo. 2014.(In Japanese).
14	Kawakami N, Takatsuka N, Inaba S and Shimizu H: Development of a screening questionnaire for tobacco/nicotine dependence according to ICD-10, DSM-III-R, and DSM-IV. Addict Behav. 24:155–166. 1999. View Article : Google Scholar : PubMed/NCBI
15	Inaba Y, Koide S, Yokoyama K and Karube I: Development of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) measurement method combined with SPE. J Chromatogr Sci. 49:303–309. 2011. View Article : Google Scholar : PubMed/NCBI
16	Kim I, Darwin WD and Huestis MA: Simultaneous determination of nicotine, cotinine, norcotinine, and trans-3′-hydroxycotinine in human oral fluid using solid phase extraction and gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 814:233–240. 2005. View Article : Google Scholar : PubMed/NCBI
17	Suzuki I, Kawakami N and Shimizu H: Reliability and validity of a questionnaire for assessment of energy expenditure and physical activity in epidemiological studies. J Epidemiol. 8:152–159. 1998. View Article : Google Scholar : PubMed/NCBI
18	Kobayashi S, Murakami K, Sasaki S, Okubo H, Hirota N, Notsu A, Fukui M and Date C: Comparison of relative validity of food group intakes estimated by comprehensive and brief-type self-administered diet history questionnaires against 16 d dietary records in Japanese adults. Public Health Nutr. 14:1200–1211. 2011. View Article : Google Scholar : PubMed/NCBI
19	Willett W and Stampfer MJ: Total energy intake: Implications for epidemiologic analyses. Am J Epidemiol. 124:17–27. 1986. View Article : Google Scholar : PubMed/NCBI
20	Tamae K, Kawai K, Yamasaki S, Kawanami K, Ikeda M, Takahashi K, Miyamoto T, Kato N and Kasai H: Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine. Cancer Sci. 100:715–721. 2009. View Article : Google Scholar : PubMed/NCBI
21	Nordin TC, Done AJ and Traustadottir T: Acute exercise increases resistance to oxidative stress in young but not older adults. Age (Dordr). 36:97272014. View Article : Google Scholar : PubMed/NCBI
22	Hori A, Kasai H, Kawai K, Nanri A, Sato M, Ohta M and Mizoue T: Coffee intake is associated with lower levels of oxidative DNA damage and decreasing body iron storage in healthy women. Nutr Cancer. 66:964–969. 2014. View Article : Google Scholar : PubMed/NCBI
23	Thompson HJ, Heimendinger J, Sedlacek S, Haegele A, Diker A, O'Neill C, Meinecke B, Wolfe P, Zhu Z and Jiang W: 8-Isoprostane F₂alpha excretion is reduced in women by increased vegetable and fruit intake. Am J Clin Nutr. 82:768–776. 2005. View Article : Google Scholar : PubMed/NCBI
24	Hodgson JM, Ward NC, Burke V, Beilin LJ and Puddey IB: Increased lean red meat intake does not elevate markers of oxidative stress and inflammation in humans. J Nutr. 137:363–367. 2007. View Article : Google Scholar : PubMed/NCBI
25	Hori A, Mizoue T, Kasai H, Kawai K, Matsushita Y, Nanri A, Sato M and Ohta M: Body iron store as a predictor of oxidative DNA damage in healthy men and women. Cancer Sci. 101:517–522. 2010. View Article : Google Scholar : PubMed/NCBI
26	Irie M, Tamae K, Iwamoto-Tanaka N and Kasai H: Occupational and lifestyle factors and urinary 8-hydroxydeoxyguanosine. Cancer Sci. 96:600–606. 2005. View Article : Google Scholar : PubMed/NCBI
27	Yeon JY, Suh YJ, Kim SW, Baik HW, Sung CJ, Kim HS and Sung MK: Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk. Nutrition. 27:912–918. 2011. View Article : Google Scholar : PubMed/NCBI
28	McAnulty S, McAnulty L, Nieman D, Morrow J, Dumke C and Utter A: Carbohydrate effect: Hormone and oxidative changes. Int J Sports Med. 28:921–927. 2007. View Article : Google Scholar : PubMed/NCBI
29	Grassi G, Seravalle G, Calhoun DA, Bolla G and Mancia G: Cigarette smoking and the adrenergic nervous system. Clin Exp Hypertens A. 14:251–260. 1992.PubMed/NCBI
30	Davi G, Ciabattoni G, Consoli A, Mezzetti A, Falco A, Santarone S, Pennese E, Vitacolonna E, Bucciarelli T, Costantini F, et al: In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: Effects of improved metabolic control and vitamin E supplementation. Circulation. 99:224–229. 1999. View Article : Google Scholar : PubMed/NCBI
31	Helmersson J, Arnlöv J, Larsson A and Basu S: Low dietary intake of beta-carotene, alpha-tocopherol and ascorbic acid is associated with increased inflammatory and oxidative stress status in a Swedish cohort. Br J Nutr. 101:1775–1782. 2009. View Article : Google Scholar : PubMed/NCBI
32	Anderson C, Milne GL, Sandler DP and Nichols HB: Oxidative stress in relation to diet and physical activity among premenopausal women. Br J Nutr. 116:1416–1424. 2016. View Article : Google Scholar : PubMed/NCBI
33	Hopkins MH, Fedirko V, Jones DP, Terry PD and Bostick RM: Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: Results from a randomized, controlled clinical trial. Cancer Epidemiol Biomarkers Prev. 19:850–858. 2010. View Article : Google Scholar : PubMed/NCBI
34	Palozza P, Serini S, Trombino S, Lauriola L, Ranelletti FO and Calviello G: Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: Dependence on pO2. Carcinogenesis. 27:2383–2391. 2006. View Article : Google Scholar : PubMed/NCBI