Open Access

miRNA‑766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4

  • Authors:
    • Weirong Chen
    • Gaoyang Cai
    • Ziqun Liao
    • Kaihuang Lin
    • Guangrong Li
    • Yanchong Li
  • View Affiliations

  • Published online on: March 26, 2019     https://doi.org/10.3892/etm.2019.7436
  • Pages: 4100-4108
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

miRNAs are closely associated with tumor genesis and development. The present study investigated the role of the expression of miRNA‑766 in the survival of patients with colon cancer and the underlying molecular mechanisms. Reverse transcription‑quantitative polymerase chain reaction analysis and microarray analysis were used to analyze the expression of miRNA‑766. The results revealed that the expression of miRNA‑766 was decreased in patients with colon cancer. The overall survival and disease‑free survival rates of patients with colon cancer with a high expression of miRNA‑766 were prolonged, compared with those with a low expression of miRNA‑766. The overexpression of miRNA‑766 reduced cell growth and induced apoptosis in colon cancer cells through suppression of the MDM4/p53 pathway. By contrast, the downregulation of miRNA‑766 promoted cell growth and reduced apoptosis in colon cancer cells through activation of the MDM4/p53 pathway. The promotion of MDM4 attenuated the anticancer effect of miRNA‑766 in colon cancer cells. These results demonstrated that miRNA‑766 induced cell apoptosis in human colon cancer through MDM4/p53.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen W, Cai G, Liao Z, Lin K, Li G and Li Y: miRNA‑766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4. Exp Ther Med 17: 4100-4108, 2019.
APA
Chen, W., Cai, G., Liao, Z., Lin, K., Li, G., & Li, Y. (2019). miRNA‑766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4. Experimental and Therapeutic Medicine, 17, 4100-4108. https://doi.org/10.3892/etm.2019.7436
MLA
Chen, W., Cai, G., Liao, Z., Lin, K., Li, G., Li, Y."miRNA‑766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4". Experimental and Therapeutic Medicine 17.5 (2019): 4100-4108.
Chicago
Chen, W., Cai, G., Liao, Z., Lin, K., Li, G., Li, Y."miRNA‑766 induces apoptosis of human colon cancer cells through the p53/Bax signaling pathway by MDM4". Experimental and Therapeutic Medicine 17, no. 5 (2019): 4100-4108. https://doi.org/10.3892/etm.2019.7436