Correlation between serum transforming growth factor β1, interleukin‑6 and neonatal respiratory distress syndrome

Chen,Feng; Huang,Fang; Zhan,Fei

doi:10.3892/etm.2019.7585

Correlation between serum transforming growth factor β1, interleukin‑6 and neonatal respiratory distress syndrome

Authors:
- Feng Chen
- Fang Huang
- Fei Zhan
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Affiliations: Department of Pediatrics, Xiangyang Central Hospital, Affiliated of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China
Published online on: May 15, 2019 https://doi.org/10.3892/etm.2019.7585
Pages: 671-677
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Trend and correlation of transforming growth factor β1 (TGF‑β1) and interleukin‑6 (IL‑6) in serum of children with neonatal respiratory distress syndrome (NRDS) were investigated. A total of 75 NRDS children born in the Xiangyang Central Hospital from July 2015 to August 2017 were analyzed retrospectively. A total of 45 NRDS premature infants who received pulmonary surfactant (PS) within 12 h after birth were treated as PS group, 30 who did not receive PS treatment as non‑PS group, and 32 premature infants without NRDS in the same period were selected as control group. Serum levels of TGF‑β1 and IL‑6 were detected by enzyme linked immunosorbent assay (ELISA) at various time points after birth and their correlation was analyzed. The expression level of TGF‑β1 in serum of children in PS group was significantly higher than that in control group on days 1 and 3 after birth (P<0.05). The expression level of TGF‑β1 in non‑PS group increased continuously with the increase of number of days and was significantly higher than that in control group on days 1, 3 and 7 after birth (P<0.05), and significantly higher than that in PS group on days 3 and 7 after birth (P<0.05). The analysis of the correlation between the severity of the disease and the expression levels of TGF‑β1 and IL‑6 showed that the expression levels were elevated with the increase of the disease severity. The expression levels of TGF‑β1 and IL‑6 were positively correlated with severity of the disease (r=0.7509, P<0.05; r=0.8056, P<0.05). The expression levels of TGF‑β1 and IL‑6 in PS and non‑PS groups were positively correlated (r=0.9042, P<0.05; r=0.8905, P<0.05). The results showed that serum TGF‑β1 and IL‑6 were elevated in NRDS children, and there was a positive correlation between them.

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