Efficacy of 3% hypertonic saline in bronchiolitis: A meta‑analysis

  • Authors:
    • Zhi‑Yong Wang
    • Xiao‑Dong Li
    • Ai‑Ling Sun
    • Xue‑Qin Fu
  • View Affiliations

  • Published online on: June 18, 2019     https://doi.org/10.3892/etm.2019.7684
  • Pages: 1338-1344
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Abstract

A meta‑analysis was performed to analyze the efficacy of 3% hypertonic saline (HS) in bronchiolitis. Pubmed and MEDLINE databases were searched for relevant articles. A total of 2 authors selected the articles according to the inclusion criteria and then data were carefully extracted. Weighted mean difference (WMD) with 95% confidence interval (95% CI) values were used to pool continuous data, including length of stay and clinical severity score (CSS). Relative risk (RR) with 95% CI was calculated to determine the association between 3% HS and re‑admission. The pooled data revealed that infants treated with 3% HS exhibited shorter durations of hospitalization compared with those treated with normal saline (NS; WMD=‑0.43; 95% CI=‑0.70, ‑0.15). Subgroup analysis examining the combination of HS or NS with additional medication demonstrated that 3% HS with epinephrine significantly decreased the length of hospital stay, with a WMD=‑0.62 (95% CI=‑0.90, ‑0.33). The results indicated a lower CSS score in the 3% HS group compared with the NS group (SMD=‑0.80; 95% CI=‑1.06, ‑0.54). The pooled outcome indicated a beneficial effect of 3% HS on decreasing re‑admission rates compared with NS (RR=0.93; 95% CI=0.70, 1.23). No potential publication bias was observed (Begg's, P=0.133; Egger's, P=0.576). In conclusion, 3% HS was demonstrated to be a more successful therapy compared with NS for infants with bronchiolitis.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang ZY, Li XD, Sun AL and Fu XQ: Efficacy of 3% hypertonic saline in bronchiolitis: A meta‑analysis. Exp Ther Med 18: 1338-1344, 2019.
APA
Wang, Z., Li, X., Sun, A., & Fu, X. (2019). Efficacy of 3% hypertonic saline in bronchiolitis: A meta‑analysis. Experimental and Therapeutic Medicine, 18, 1338-1344. https://doi.org/10.3892/etm.2019.7684
MLA
Wang, Z., Li, X., Sun, A., Fu, X."Efficacy of 3% hypertonic saline in bronchiolitis: A meta‑analysis". Experimental and Therapeutic Medicine 18.2 (2019): 1338-1344.
Chicago
Wang, Z., Li, X., Sun, A., Fu, X."Efficacy of 3% hypertonic saline in bronchiolitis: A meta‑analysis". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1338-1344. https://doi.org/10.3892/etm.2019.7684