Acute cytomegalovirus infection in an immunocompetent patient with ulcerative colitis: A case report

Maeda,Toshihide; Sakai,Hiroyasu; Ozawa,Noritaka; Sugiyama,Tomohiko; Takada,Jun; Kubota,Masaya; Ibuka,Takashi; Shirakami,Yohei; Araki,Hiroshi; Shimizu,Masahito

doi:10.3892/etm.2019.7823

Acute cytomegalovirus infection in an immunocompetent patient with ulcerative colitis: A case report

Authors:
- Toshihide Maeda
- Hiroyasu Sakai
- Noritaka Ozawa
- Tomohiko Sugiyama
- Jun Takada
- Masaya Kubota
- Takashi Ibuka
- Yohei Shirakami
- Hiroshi Araki
- Masahito Shimizu
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Affiliations: Department of Gastroenterology, Gifu University Hospital, Gifu 501‑1194, Japan
Published online on: July 26, 2019 https://doi.org/10.3892/etm.2019.7823
Pages: 2271-2277

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Abstract

Cytomegalovirus (CMV) is a ubiquitous member of the Herpesviridae family that can present with a variety of clinical manifestations, including encephalitis, retinitis, interstitial pneumonia and colitis. These serious symptoms are generally observed as opportunistic infections in immunocompromised hosts, including patients with acquired immunodeficiency syndrome and those receiving steroids and/or immunosuppressants. Symptomatic CMV infections in patients with ulcerative colitis are found in patients treated with steroids and/or immunosuppressants but rarely affect those who are not taking these agents. The present study reported the case of a young patient without concurrent use of immunosuppressive agents for the treatment of ulcerative colitis. The patient presented with acute mononucleosis and colitis caused by primary CMV infection. This was characterized by the presence of atypical lymphocytes and hepatosplenomegaly, elevation of transaminase levels, serology‑positive anti‑CMV IgM, and CMV antigenemia. Additionally, CMV‑positive cells were histologically detected in colonic biopsy specimens. The patient's symptoms and clinical parameters improved following initiation of intravenous ganciclovir. It was concluded that even if patients with ulcerative colitis are not treated with steroids and/or immunosuppressants, significant attention should be paid to acute CMV infections in the context of severe or persistent colonic inflammation.

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