Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF

Huang,Wei; Gan,Wei; Huang,An; Fu,Yulei; Shang,Yuzhi; Chen,Yue; Tian,Zhao; Zhang,Yun; Fang,Gang

doi:10.3892/etm.2019.7977

Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF

Authors:
- Wei Huang
- Wei Gan
- An Huang
- Yulei Fu
- Yuzhi Shang
- Yue Chen
- Zhao Tian
- Yun Zhang
- Gang Fang
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Affiliations: The First Clinical Faculty, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530023, P.R. China, College of Pharmacy, Minzu University of China, Beijing 100081, P.R. China, Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China, Graduate School of Hubei University for Nationalities, Enshi, Hubei 445000, P.R. China, Laboratory of Zhuang Medicine Prescriptions Basis and Application Research, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China
Published online on: September 6, 2019 https://doi.org/10.3892/etm.2019.7977
Pages: 3470-3474
Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients, and its effect on the levels of serum inflammatory cytokines, norepinephrine (NE) and brain‑derived neurotrophic factor (BDNF) were investigated. A total of 104 patients with depression and chronic diarrhea admitted to The First Clinical Faculty, Guangxi University of Traditional Chinese Medicine from July 2014 to June 2018 were randomly divided into the observation group (n=56) and the control group (n=48). The observation group was treated with electroacupuncture combined with probiotics, and the control group was given conventional drugs for depression and chronic diarrhea. The Hamilton Depression Rating Scale (HAM‑D) score and the abdominal symptom score were evaluated before treatment and at 3 weeks after treatment. Changes in the levels of serum inflammatory cytokines [interleukin (IL)‑6, IL‑2 and tumor necrosis factor (TNF)‑α] as well as the levels of NE and BDNF in the two groups of patients before and after treatment were determined using radioimmunoassay. Compared with those in the control group, the symptoms of depression and diarrhea in the observation group were remarkably alleviated (p<0.05). After treatment, the serum cytokine levels in the two groups of patients were decreased, and the decreased level of serum inflammatory cytokines in the observation group was not obviously different from that in the control group. Besides, the serum BDNF level in the observation group was also reduced (p<0.05). The overall efficacy of the observation group was superior to that of the control group, showing a statistical difference. Electroacupuncture combined with probiotics brings good efficacy to patients with depression and chronic diarrhea, which is worthy of clinical promotion and development.

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