Open Access

Exogenous brain‑derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats

  • Authors:
    • Huayun Chen
    • Yanwei Dang
    • Xiao Liu
    • Junwei Ren
    • Hongquan Wang
  • View Affiliations

  • Published online on: September 19, 2019     https://doi.org/10.3892/etm.2019.8029
  • Pages: 3837-3844
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Brain‑derived neurotrophic factor (BDNF) is a growth factor crucial for neuronal survival, while its role in subarachnoid hemorrhage (SAH)‑induced neuronal apoptosis remains unclear. The aim of the present study was to investigate whether administering exogenous BDNF can protect against neuronal apoptosis and neurological deficits following SAH in a rat model. The BDNF level was found to be significantly decreased in the basal cortex at 6, 12, 24, 48 and 72 h following SAH. Exogenous BDNF significantly decreased the expression of Bax and reduced activation of caspase‑3 and caspase‑9 and the number of apoptotic neurons. Moreover, exogenous BDNF treatment significantly improved the neurological deficits at 72 h and long‑term behavioral deficits (day 14) following SAH in a rat model. These findings indicate that exogenous BDNF attenuated SAH‑induced neuronal injury in rats.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen H, Dang Y, Liu X, Ren J and Wang H: Exogenous brain‑derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats. Exp Ther Med 18: 3837-3844, 2019.
APA
Chen, H., Dang, Y., Liu, X., Ren, J., & Wang, H. (2019). Exogenous brain‑derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats. Experimental and Therapeutic Medicine, 18, 3837-3844. https://doi.org/10.3892/etm.2019.8029
MLA
Chen, H., Dang, Y., Liu, X., Ren, J., Wang, H."Exogenous brain‑derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats". Experimental and Therapeutic Medicine 18.5 (2019): 3837-3844.
Chicago
Chen, H., Dang, Y., Liu, X., Ren, J., Wang, H."Exogenous brain‑derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3837-3844. https://doi.org/10.3892/etm.2019.8029