Open Access

Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report

  • Authors:
    • Qiong Chen
    • Kuang Chen
    • Shenxian Qian
    • Shenghai Wu
    • Lihui Xu
    • Xilian Huang
    • Pengfei Shi
    • Kaile Wang
    • Minmin Wang
    • Xianjun Wang
  • View Affiliations

  • Published online on: September 27, 2019     https://doi.org/10.3892/etm.2019.8065
  • Pages: 4076-4080
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mucormycosis is an angioinvasive fungal infection with a high mortality rate. Patients with hematological malignancies following voriconazole therapy are at high risk from mucormycosis. Here, the present study reports on a 68‑year‑old man diagnosed with multiple myeloma and secondary myelodysplastic syndrome, who was infected with disseminated mucormycosis with cerebellum involvement confirmed by mycological culture and histopathological examination. For patients with hematological malignancies who are receiving antifungal therapy, an opportunistic infection of mucormycosis should be considered if a ‘breakthrough’ infection occurs in the predilection sites (such as the sinuses, lungs, skin, brain and gastrointestinal tract). It is difficult to diagnose mucormycosis because of the limited reliable detection methods, and because mucormycosis often presents with an acute onset and progresses rapidly, particularly in immunocompromised patients. Antifungal therapy with amphotericin B or posaconazole should be started as soon as possible considering the empirical diagnosis.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen Q, Chen K, Qian S, Wu S, Xu L, Huang X, Shi P, Wang K, Wang M, Wang X, Wang X, et al: Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report. Exp Ther Med 18: 4076-4080, 2019.
APA
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X. ... Wang, X. (2019). Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report. Experimental and Therapeutic Medicine, 18, 4076-4080. https://doi.org/10.3892/etm.2019.8065
MLA
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X., Shi, P., Wang, K., Wang, M., Wang, X."Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report". Experimental and Therapeutic Medicine 18.5 (2019): 4076-4080.
Chicago
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X., Shi, P., Wang, K., Wang, M., Wang, X."Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4076-4080. https://doi.org/10.3892/etm.2019.8065