Clinical effect of single covered stent and double covered stent on TIPS in the treatment of hemorrhage due to rupture of esophageal and gastric varices in cirrhosis and its influence on immune function

Xu,Bo; Liu,Jia; Liu,Shunhai; Xiang,Xin; Lai,Liang

doi:10.3892/etm.2019.8106

Clinical effect of single covered stent and double covered stent on TIPS in the treatment of hemorrhage due to rupture of esophageal and gastric varices in cirrhosis and its influence on immune function

Authors:
- Bo Xu
- Jia Liu
- Shunhai Liu
- Xin Xiang
- Liang Lai
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Affiliations: Department of Hepatobiliary Surgery, The First People's Hospital of Neijiang, Neijiang, Sichuan 641000, P.R. China, Department of Anesthesiology, The First People's Hospital of Neijiang, Neijiang, Sichuan 641000, P.R. China
Published online on: October 15, 2019 https://doi.org/10.3892/etm.2019.8106
Pages: 4259-4264
Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Clinical effect of single covered stent and double covered stent in transjugular intrahepatic portosystemic shunt (TIPS) in the treatment of hemorrhage due to rupture of esophageal and gastric varices in cirrhosis and its influence on the immune function of patients was investigated. Altogether 124 patients with liver cirrhosis and esophageal and gastric varices bleeding who were admitted to the First People's Hospital of Neijiang from February 2012 to April 2016 were selected as research objects and divided into group A and B. Group A (65 cases) was treated with simple covered stent, and group B (59 cases) was treated with double covered stent simulating Viatorr technique. The therapeutic effect of the two groups after operation was observed. The changes of portal vein pressure before and after treatment and the changes of esophageal and gastric varices after operation were observed. The levels of peripheral blood T lymphocyte subsets (CD3+, CD4+ and CD4+/CD8+) were detected by flow cytometry. The therapeutic effect of group B was higher than that of group A (P>0.05). The postoperative portal vein pressure in group B was significantly lower than that in group A (P<0.05). The disappearance rate and overall effective rate of varicose veins in group B were better than those in group A (P>0.05). After three days of treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the peripheral blood of group B were higher than those of group A (P>0.05), while the decline rate of CD3+, CD4+, CD4+/CD8+ in the peripheral blood of group B was higher than that of group A after seven days of treatment. Double‑stent simulated Viatorr has a higher effective rate, has a certain improvement on the immune function of patients, and the survival rate is also higher than that of single covered stent, which is worthy of clinical application and promotion.

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