Open Access

The inhibitor of autophagy SBI‑0206965 aggravates atherosclerosis through decreasing myeloid‑derived suppressor cells

  • Authors:
    • Bo Wang
    • Guanjun Dong
    • Qingqiing Zhang
    • Fenglian Yan
    • Zhihua Li
    • Chunxia Li
    • Hui Zhang
    • Qun Ma
    • Jun Dai
    • Chuanping Si
    • Huabao Xiong
  • View Affiliations

  • Published online on: December 11, 2019     https://doi.org/10.3892/etm.2019.8317
  • Pages: 1370-1378
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Atherosclerosis (AS) is currently the leading cause of mortality worldwide, with the development of new strategies to prevent the formation and rupture of atherosclerotic plaques being a paramount area of research. Amounting evidence suggests autophagy has an important role in the pathogenesis of AS and may be a potential therapeutic target. In this study, the effect of SBI‑0206965(6965), a novel inhibitor of autophagy, was tested on the development of AS in apolipoprotein E deficient (ApoE‑/‑) mice. Systemic application of 6965 was found to aggravate AS, with increased plaque size and decreased plaque stability in comparison with the control. Of note, it was observed that 6965 decreased the proportion of myeloid‑derived suppressor cells (MDSCs). Further investigation demonstrated MDSCs markedly alleviated AS in ApoE‑/‑ mice; while 6965 reduced the viability and promoted apoptosis of MDSCs in vitro. This is the first study describing an association between autophagy and MDSCs in AS models, providing a novel mechanism to potentially target in the management of this condition.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang B, Dong G, Zhang Q, Yan F, Li Z, Li C, Zhang H, Ma Q, Dai J, Si C, Si C, et al: The inhibitor of autophagy SBI‑0206965 aggravates atherosclerosis through decreasing myeloid‑derived suppressor cells. Exp Ther Med 19: 1370-1378, 2020.
APA
Wang, B., Dong, G., Zhang, Q., Yan, F., Li, Z., Li, C. ... Xiong, H. (2020). The inhibitor of autophagy SBI‑0206965 aggravates atherosclerosis through decreasing myeloid‑derived suppressor cells. Experimental and Therapeutic Medicine, 19, 1370-1378. https://doi.org/10.3892/etm.2019.8317
MLA
Wang, B., Dong, G., Zhang, Q., Yan, F., Li, Z., Li, C., Zhang, H., Ma, Q., Dai, J., Si, C., Xiong, H."The inhibitor of autophagy SBI‑0206965 aggravates atherosclerosis through decreasing myeloid‑derived suppressor cells". Experimental and Therapeutic Medicine 19.2 (2020): 1370-1378.
Chicago
Wang, B., Dong, G., Zhang, Q., Yan, F., Li, Z., Li, C., Zhang, H., Ma, Q., Dai, J., Si, C., Xiong, H."The inhibitor of autophagy SBI‑0206965 aggravates atherosclerosis through decreasing myeloid‑derived suppressor cells". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1370-1378. https://doi.org/10.3892/etm.2019.8317