Open Access

MicroRNA‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1

Retraction in: /10.3892/etm.2024.12451

  • Authors:
    • Juan Feng
    • Tingfeng Wang
  • View Affiliations

  • Published online on: December 18, 2019     https://doi.org/10.3892/etm.2019.8348
  • Pages: 1243-1250
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is a common gynecological malignancy with high morbidity worldwide. MicroRNAs (miRNAs) serve critical roles in cervical cancer progression. Accumulating evidence indicates that miR‑873 functions as a tumor suppressor in certain types of cancer. However, the function and mechanism of miR‑873 in the progression of cervical cancer have not been completely elucidated. In the present study, the role and mechanism of miR‑873 in the proliferation, migration and invasion of cervical cancer cells were investigated. miR‑873 expression was markedly decreased in cervical cancer, while glioma‑associated oncogene homolog 1 (GLI1) was found to be a direct target of miR‑873 by conducting dual‑luciferase reporter assays. Furthermore, miR‑873 overexpression reduced the expression of GLI1, and decreased the proliferation, metastasis and epithelial‑mesenchymal transition of cancer cells. In rescue experiments, overexpression of GLI1 in cervical cancer cells effectively reversed the inhibitory effect induced by miR‑873 mimics. Therefore, the results of the present study suggested that miR‑873 functions as a tumor suppressor miRNA, and future studies should address its potential application in the treatment of cervical cancer.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Feng J and Feng J: MicroRNA‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1 Retraction in /10.3892/etm.2024.12451. Exp Ther Med 19: 1243-1250, 2020
APA
Feng, J., & Feng, J. (2020). MicroRNA‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1 Retraction in /10.3892/etm.2024.12451. Experimental and Therapeutic Medicine, 19, 1243-1250. https://doi.org/10.3892/etm.2019.8348
MLA
Feng, J., Wang, T."MicroRNA‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1 Retraction in /10.3892/etm.2024.12451". Experimental and Therapeutic Medicine 19.2 (2020): 1243-1250.
Chicago
Feng, J., Wang, T."MicroRNA‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1 Retraction in /10.3892/etm.2024.12451". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1243-1250. https://doi.org/10.3892/etm.2019.8348