Telomere length and telomerase activity in osteoporosis and osteoarthritis (Review)

Fragkiadaki,Persefoni; Nikitovic,Dragana; Kalliantasi,Katerina; Sarandi,Evangelia; Thanasoula,Maria; Stivaktakis,Polychronis D.; Nepka,Charitini; Spandidos,Demetrios A.; Tosounidis,Theodoros; Tsatsakis,Aristidis

doi:10.3892/etm.2019.8370

Telomere length and telomerase activity in osteoporosis and osteoarthritis (Review)

Authors:
- Persefoni Fragkiadaki
- Dragana Nikitovic
- Katerina Kalliantasi
- Evangelia Sarandi
- Maria Thanasoula
- Polychronis D. Stivaktakis
- Charitini Nepka
- Demetrios A. Spandidos
- Theodoros Tosounidis
- Aristidis Tsatsakis
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Affiliations: Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Anatomy‑Histology‑Embryology, Medical School, University of Crete, 71003 Heraklion, Greece, Metabolomic Medicine, Health Clinic for Autoimmune and Chronic Diseases, 10674 Athens, Greece, Department of Cytopathology, University Hospital of Larissa, 41110 Larissa, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Orthopedics, School of Medicine, University of Crete, 71003 Heraklion, Greece
Published online on: December 24, 2019 https://doi.org/10.3892/etm.2019.8370
Pages: 1626-1632
Copyright: © Fragkiadaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) and osteoporosis (OP) are associated skeletal pathologies and have as a distinct feature the abnormal reconstruction of the subchondral bone. OA and OP have been characterized as age‑related diseases and have been associated with telomere shortening and altered telomerase activity (TA). This review discusses the role of telomeres and telomerase in OA and OP pathologies and focuses on the usability of telomere length (TL) and the rate of telomere shortening as potential disease biomarkers. A number of studies have demonstrated that telomere shortening may contribute to OA and OP as an epigenetic factor. Therefore, it has been claimed that the measurement of TL of chondrocytes and/or peripheral blood cells may be an appropriate marker for the evaluation of the progression of these diseases. However, there is a need to be perform further studies with larger cohorts, with the aim of obtaining objective results and a better understanding of the association between TL, inflammation and aging, in order to provide further insight into the pathophysiology of degenerative joint diseases.

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