Open Access

Effects of different triglyceride‑lowering therapies in patients with hypertriglyceridemia‑induced acute pancreatitis

  • Authors:
    • Shanshan Yu
    • Dongqi Yao
    • Xianquan Liang
    • Kui Jin
    • Yangyang Fu
    • Danyu Liu
    • Lili Zhang
    • Jing Yang
    • Xiao Song
    • Jun Xu
    • Xuezhong Yu
  • View Affiliations

  • Published online on: February 7, 2020     https://doi.org/10.3892/etm.2020.8501
  • Pages: 2427-2432
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to investigate the effects of various triglyceride (TG)‑lowering therapies on hypertriglyceridemia‑induced acute pancreatitis (HTGAP). A total of 132 patients with HTGAP were retrospectively divided into an insulin intensive therapy (IIT), a plasma exchange (PE) and a non‑intensive insulin therapy (NIIT) group according to the TG‑lowering therapies they had received. The clinical and biochemical data of the subjects were analyzed. The baseline data, including sex, age, TG, amylase, severe acute pancreatitis and systemic inflammatory response syndrome were not significantly different among the three groups (P>0.05). The 24‑h TG clearance rate (χ2=7.74, P=0.021), onset to treatment time (χ2=14.50, P<0.001) and the time required to reach the target TG level (χ2=6.12, P=0.047) were different in these three groups, but no significant differences were observed between the IIT and NIIT groups (P>0.05). The incidence of therapy‑associated complications in the PE group (30.23%) was higher than that in the IIT (2.17%) and NIIT (4.65%) groups. The difference in the incidence of therapy‑associated complications was significant among the three groups (P<0.001), but no significant difference was present between the IIT and NIIT groups (P>0.05). In the PE group, the length of stay was increased compared with that in the IIT and NIIT groups (χ2=7.05, P<0.05), while there was no significant difference between the IIT and NIIT groups (P>0.05). The present study suggested that NIIT at presentation had a similar therapeutic efficacy to that of IIT to improve the prognosis of HTGAP, and NIIT and IIT were associated with fewer complications than PE treatment. NIIT may favorably perform in patients presenting early after symptom onset and may be considered for clinical application.
View Figures
View References

Related Articles

Journal Cover

April-2020
Volume 19 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yu S, Yao D, Liang X, Jin K, Fu Y, Liu D, Zhang L, Yang J, Song X, Xu J, Xu J, et al: Effects of different triglyceride‑lowering therapies in patients with hypertriglyceridemia‑induced acute pancreatitis. Exp Ther Med 19: 2427-2432, 2020.
APA
Yu, S., Yao, D., Liang, X., Jin, K., Fu, Y., Liu, D. ... Yu, X. (2020). Effects of different triglyceride‑lowering therapies in patients with hypertriglyceridemia‑induced acute pancreatitis. Experimental and Therapeutic Medicine, 19, 2427-2432. https://doi.org/10.3892/etm.2020.8501
MLA
Yu, S., Yao, D., Liang, X., Jin, K., Fu, Y., Liu, D., Zhang, L., Yang, J., Song, X., Xu, J., Yu, X."Effects of different triglyceride‑lowering therapies in patients with hypertriglyceridemia‑induced acute pancreatitis". Experimental and Therapeutic Medicine 19.4 (2020): 2427-2432.
Chicago
Yu, S., Yao, D., Liang, X., Jin, K., Fu, Y., Liu, D., Zhang, L., Yang, J., Song, X., Xu, J., Yu, X."Effects of different triglyceride‑lowering therapies in patients with hypertriglyceridemia‑induced acute pancreatitis". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2427-2432. https://doi.org/10.3892/etm.2020.8501