Open Access

Association between fetal chromosomal abnormalities and the frequency of spontaneous abortions

  • Authors:
    • Lan Yang
    • Tao Tao
    • Xin Zhao
    • Hehua Tao
    • Jingna Su
    • Ye Shen
    • Ye Tang
    • Fangbo Qian
    • Jianping Xiao
  • View Affiliations

  • Published online on: February 11, 2020     https://doi.org/10.3892/etm.2020.8524
  • Pages: 2505-2510
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fetal chromosomal abnormalities are a common cause of spontaneous abortion. The present study investigated the association between fetal chromosomal abnormalities and the frequency of spontaneous abortions to enable clinicians to provide more informed genetic counseling. A total of 182 patients with a history of spontaneous abortions were recruited from July 2015 to August 2017. G‑banding cytogenetic analysis and novel high‑throughput ligation‑dependent probe amplification (HLPA) techniques were performed on conception in all 182 patients to detect chromosomal abnormalities. Low‑coverage whole‑genome sequencing (WGS) was performed in 74 patients to detect copy number variations (CNVs). There were no significant differences in the incidence of karyotype abnormalities between patients with sporadic miscarriages (48.0%; SM group) and patients suffering recurrent spontaneous abortions (44.8%; RSA group). The maternal age was markedly higher in patients with 3 miscarriages. WGS indicated that the incidence of pathogenic CNVs in the RSA group was higher than that in the SM group, but the difference was not significant. In conclusion, a high incidence of karyotype abnormalities and pathogenic CNVs was observed in patients with spontaneous abortion. However, no association between fetal chromosomal abnormalities and the number of spontaneous abortions was observed. HLPA assays may be used as an alternative method for fetal karyotype analysis and determination of CNVs in patients with SM and RSA.
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April-2020
Volume 19 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yang L, Tao T, Zhao X, Tao H, Su J, Shen Y, Tang Y, Qian F and Xiao J: Association between fetal chromosomal abnormalities and the frequency of spontaneous abortions. Exp Ther Med 19: 2505-2510, 2020
APA
Yang, L., Tao, T., Zhao, X., Tao, H., Su, J., Shen, Y. ... Xiao, J. (2020). Association between fetal chromosomal abnormalities and the frequency of spontaneous abortions. Experimental and Therapeutic Medicine, 19, 2505-2510. https://doi.org/10.3892/etm.2020.8524
MLA
Yang, L., Tao, T., Zhao, X., Tao, H., Su, J., Shen, Y., Tang, Y., Qian, F., Xiao, J."Association between fetal chromosomal abnormalities and the frequency of spontaneous abortions". Experimental and Therapeutic Medicine 19.4 (2020): 2505-2510.
Chicago
Yang, L., Tao, T., Zhao, X., Tao, H., Su, J., Shen, Y., Tang, Y., Qian, F., Xiao, J."Association between fetal chromosomal abnormalities and the frequency of spontaneous abortions". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2505-2510. https://doi.org/10.3892/etm.2020.8524