Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway

Corrigendum in: /10.3892/etm.2024.12531

  • Authors:
    • Chunmao Jiang
    • Haifeng Yang
    • Xiaolan Chen
    • Shulei Qiu
    • Caihong Wu
    • Bin Zhang
    • Liqin Jin
  • View Affiliations

  • Published online on: May 18, 2020     https://doi.org/10.3892/etm.2020.8766
  • Pages: 1137-1144
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Abstract

Accumulating evidence demonstrates that Macleaya cordata extract exerts antiviral and anti‑inflammatory effects in various diseases. The present study aimed to investigate the potential effects of M. cordata on rotavirus SA11‑induced diarrhea in mice. Diarrhea severity, levels of inflammatory cytokines, histological changes in the small intestine and the underlying mechanisms were evaluated in rotavirus‑stimulated mice treated with 1, 2 and 4 mg/kg/day M. cordata or 4 mg/kg/day ribavirin (positive control). M. cordata treatment effectively ameliorated rotavirus‑induced diarrhea in a dose‑dependent manner by decreasing viral RNA levels. In addition, M. cordata reduced the release of pro‑inflammatory cytokines including migration inhibitory factor, interleukin (IL)‑8, IL‑β, interferon‑γ and tumor necrosis factor‑α, and elevated the secretion of the anti‑inflammatory cytokine IL‑10 following rotavirus infection. M. cordata inhibited intestinal epithelial cell apoptosis and improved intestinal inflammation after rotavirus infection. The study also revealed that M. cordata exerted antiviral and anti‑inflammatory effects on rotavirus‑induced diarrhea by suppressing the Janus kinase 2 (JAK2)/STAT3 pathway, as reflected by decreased protein expression of phosphorylated (p)‑JAK2 and p‑STAT3. Overall, M. cordata effectively inhibited the inflammation caused by rotavirus, which was closely associated with the suppression of JAK2/STAT3 phosphorylation. These data suggested that M. cordata may be applied as a treatment for rotavirus‑induced diarrhea.
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August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jiang C, Yang H, Chen X, Qiu S, Wu C, Zhang B and Jin L: Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531. Exp Ther Med 20: 1137-1144, 2020.
APA
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., & Jin, L. (2020). Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531. Experimental and Therapeutic Medicine, 20, 1137-1144. https://doi.org/10.3892/etm.2020.8766
MLA
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., Jin, L."Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531". Experimental and Therapeutic Medicine 20.2 (2020): 1137-1144.
Chicago
Jiang, C., Yang, H., Chen, X., Qiu, S., Wu, C., Zhang, B., Jin, L."Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway Corrigendum in /10.3892/etm.2024.12531". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1137-1144. https://doi.org/10.3892/etm.2020.8766