Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C

Surlin,Petra; Gheorghe,Dorin   Nicolae; Popescu,Dora   Maria; Martu,Alexandra   Maria; Solomon,Sorina; Roman,Alexandra; Lazar,Luminita; Stratul,Stefan   Ioan; Rusu,Darian; Foia,Liliana; Boldeanu,Mihail   Virgil; Boldeanu,Lidia; Danilescu,Monica; Rogoveanu,Ion

doi:10.3892/etm.2020.8906

Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C

Authors:
- Petra Surlin
- Dorin Nicolae Gheorghe
- Dora Maria Popescu
- Alexandra Maria Martu
- Sorina Solomon
- Alexandra Roman
- Luminita Lazar
- Stefan Ioan Stratul
- Darian Rusu
- Liliana Foia
- Mihail Virgil Boldeanu
- Lidia Boldeanu
- Monica Danilescu
- Ion Rogoveanu
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Affiliations: Department of Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Periodontology, Faculty of Dental Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Periodontology, Faculty of Dental Medicine, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400000 Cluj‑Napoca, Romania, Department of Periodontology, Faculty of Dental Medicine, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540139 Targu‑Mures, Romania, Department of Periodontology, Faculty of Dental Medicine, ‘Victor Babes’ University of Medicine and Pharmacy, 300230 Timisoara, Romania, Department of Biochemistry, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Immunology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Published online on: June 18, 2020 https://doi.org/10.3892/etm.2020.8906
Pages: 2381-2386
Copyright: © Surlin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The study assessed whether the increased production of interleukin‑1α (IL‑1α) and interleukin‑1β (IL‑1β), as a result of chronic hepatic inflammation, could be the expression of the negative impact on periodontal disease. The study included chronic periodontitis patients who were systemically healthy, chronic periodontitis patients suffering from chronic hepatitis C, as well as control patients, being systemically and periodontally healthy. After periodontal examination and the assessment of certain periodontal parameters, gingival crevicular fluid was collected from all participating patients. By using the enzyme‑linked immunosorbent assay method, a quantitative assessment of IL‑1α and IL‑1β levels was possible. The immunologic results were correlated to the clinical periodontal data. The gingival fluid levels of cytokines were higher for periodontitis patients with chronic hepatitis C than for the systemically healthy periodontitis patients (1.8‑fold higher for IL‑1α and 2.1‑fold higher for IL‑1β). In addition, the gingival fluid cytokine levels were significantly higher for the periodontal patients (with/without chronic hepatitis C) than for the control group. Positive correlations were found between gingival fluid IL‑1α and IL‑1β levels and certain clinical periodontal parameters or the age of the viral hepatitis C diagnosis, in periodontitis patients with chronic hepatitis C. The chronic hepatic inflammation may have an important additional negative impact on the periodontal status, as both inflammatory reactions seem to be promoted by common pro‑inflammatory cytokines.

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