Staub F and Bogousslavsky J: Post-stroke depression or fatigue. Eur Neurol. 45:3–5. 2001.PubMed/NCBI View Article : Google Scholar

Gaete JM and Bogousslavsky J: Post-stroke depression. Expert Rev Neurother. 8:75–92. 2008.PubMed/NCBI View Article : Google Scholar

Paolucci S, Iosa M, Coiro P, Venturiero V, Savo A, De Angelis D and Morone G: Post-stroke depression increases disability more than 15% in ischemic stroke survivors: A case-control study. Front Neurol. 10(926)2019.PubMed/NCBI View Article : Google Scholar

Ayerbe L, Ayis S, Wolfe CD and Rudd AG: Natural history, predictors and outcomes of depression after stroke: Systematic review and meta-analysis. Br J Psychiatry. 202:14–21. 2013.PubMed/NCBI View Article : Google Scholar

Sibolt G, Curtze S, Melkas S, Pohjasvaara T, Kaste M, Karhunen PJ, Oksala NK, Vataja R and Erkinjuntti T: Post-stroke depression and depression-executive dysfunction syndrome are associated with recurrence of ischaemic stroke. Cerebrovasc Dis. 36:336–343. 2013.PubMed/NCBI View Article : Google Scholar

Leonard B and Maes M: Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev. 36:764–785. 2012.PubMed/NCBI View Article : Google Scholar

Woelfer M, Kasties V, Kahlfuss S and Walter M: The role of depressive subtypes within the neuroinflammation hypothesis of major depressive disorder. Neuroscience. 403:93–110. 2019.PubMed/NCBI View Article : Google Scholar

Maes M: A review on the acute phase response in major depression. Rev Neurosci. 4:407–416. 1993.PubMed/NCBI View Article : Google Scholar

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, et al: Macrophage activation and polarization: Nomenclature and experimental guidelines. Immunity. 41:14–20. 2014.PubMed/NCBI View Article : Google Scholar

Robinson RG and Jorge RE: Post-stroke depression: A review. Am J Psychiatry. 173:221–231. 2016.PubMed/NCBI View Article : Google Scholar

Folstein MF, Maiberger R and McHugh PR: Mood disorder as a specific complication of stroke. J Neurol Neurosurg Psychiatry. 40:1018–1020. 1977.PubMed/NCBI View Article : Google Scholar

Narushima K, Kosier JT and Robinson RG: A reappraisal of poststroke depression, intra- and inter-hemispheric lesion location using meta-analysis. J Neuropsychiatry Clin Neurosci. 15:422–430. 2003.PubMed/NCBI View Article : Google Scholar

Spalletta G, Bossù P, Ciaramella A, Bria P, Caltagirone C and Robinson RG: The etiology of poststroke depression: A review of the literature and a new hypothesis involving inflammatory cytokines. Mol Psychiatry. 11:984–991. 2006.PubMed/NCBI View Article : Google Scholar

Carson AJ, MacHale S, Allen K, Lawrie SM, Dennis M, House A and Sharpe M: Depression after stroke and lesion location: A systematic review. Lancet. 356:122–126. 2000.PubMed/NCBI View Article : Google Scholar

Kutlubaev MA and Hackett ML: Part II: predictors of depression after stroke and impact of depression on stroke outcome: an updated systematic review of observational studies. Int J Stroke. 9:1026–1036. 2014.PubMed/NCBI View Article : Google Scholar

MacHale SM, O'Rourke SJ, Wardlaw JM and Dennis MS: Depression and its relation to lesion location after stroke. J Neurol Neurosurg Psychiatry. 64:371–374. 1998.PubMed/NCBI View Article : Google Scholar

Nys GM, van Zandvoort MJ, van der Worp HB, de Haan EH, de Kort PL and Kappelle LJ: Early depressive symptoms after stroke: Neuropsychological correlates and lesion characteristics. J Neurol Sci. 228:27–33. 2005.PubMed/NCBI View Article : Google Scholar

Terroni L, Amaro E Jr, Iosifescu DV, Tinone G, Sato JR, Leite CC, Sobreiro MF, Lucia MC, Scaff M and Fráguas R: Stroke lesion in cortical neural circuits and post-stroke incidence of major depressive episode: A 4-month prospective study. World J Biol Psychiatry. 12:539–548. 2011.PubMed/NCBI View Article : Google Scholar

Morris PL, Robinson RG, de Carvalho ML, Albert P, Wells JC, Samuels JF, Eden-Fetzer D and Price TR: Lesion characteristics and depressed mood in the stroke data bank study. J Neuropsychiatry Clin Neurosci. 8:153–159. 1996.PubMed/NCBI View Article : Google Scholar

Kim NY, Lee SC, Shin JC, Park JE and Kim YW: Voxel-based lesion symptom mapping analysis of depressive mood in patients with isolated cerebellar stroke: A pilot study. Neuroimage Clin. 13:39–45. 2017.PubMed/NCBI View Article : Google Scholar

Nishiyama Y, Komaba Y, Ueda M, Nagayama H, Amemiya S and Katayama Y: Early depressive symptoms after ischemic stroke are associated with a left lenticulocapsular area lesion. J Stroke Cerebrovasc Dis. 19:184–189. 2010.PubMed/NCBI View Article : Google Scholar

Zhang T, Jing X, Zhao X, Wang C, Liu Z, Zhou Y and Wang Y and Wang Y: A prospective cohort study of lesion location and its relation to post-stroke depression among Chinese patients. J Affect Disord. 136:e83–e87. 2012.PubMed/NCBI View Article : Google Scholar

Gozzi SA, Wood AG, Chen J, Vaddadi K and Phan TG: Imaging predictors of poststroke depression: Methodological factors in voxel-based analysis. BMJ Open. 4(e004948)2014.PubMed/NCBI View Article : Google Scholar

Grajny K, Pyata H, Spiegel K, Lacey EH, Xing S, Brophy C and Turkeltaub PE: depression symptoms in chronic left hemisphere stroke are related to dorsolateral prefrontal cortex damage. J Neuropsychiatry Clin Neurosci. 28:292–298. 2016.PubMed/NCBI View Article : Google Scholar

Shi YZ, Xiang YT, Yang Y, Zhang N, Wang S, Ungvari GS, Chiu HF, Tang WK, Wang YL, Zhao XQ, et al: Depression after minor stroke: The association with disability and quality of life - a 1-year follow-up study. Int J Geriatr Psychiatry. 31:421–427. 2016.PubMed/NCBI View Article : Google Scholar

Yu H and Chen ZY: The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol Sin. 32:3–11. 2011.PubMed/NCBI View Article : Google Scholar

Elkabes S, DiCicco-Bloom EM and Black IB: Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci. 16:2508–2521. 1996.PubMed/NCBI View Article : Google Scholar

Knott C, Stern G, Kingsbury A, Welcher AA and Wilkin GP: Elevated glial brain-derived neurotrophic factor in Parkinson's diseased nigra. Parkinsonism Relat Disord. 8:329–341. 2002.PubMed/NCBI View Article : Google Scholar

Stadelmann C, Kerschensteiner M, Misgeld T, Brück W, Hohlfeld R and Lassmann H: BDNF and gp145trkB in multiple sclerosis brain lesions: Neuroprotective interactions between immune and neuronal cells? Brain. 125:75–85. 2002.PubMed/NCBI View Article : Google Scholar

Trang T, Beggs S, Wan X and Salter MW: P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J Neurosci. 29:3518–3528. 2009.PubMed/NCBI View Article : Google Scholar

Song X, Zhou B, Zhang P, Lei D, Wang Y, Yao G, Hayashi T, Xia M, Tashiro S, Onodera S, et al: Protective effect of silibinin on learning and memory impairment in LPS-treated rats via ROS-BDNF-TrkB pathway. Neurochem Res. 41:1662–1672. 2016.PubMed/NCBI View Article : Google Scholar

Smith MA, Makino S, Kvetnansky R and Post RM: Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 15:1768–1777. 1995.PubMed/NCBI View Article : Google Scholar

Lang UE, Hellweg R, Kalus P, Bajbouj M, Lenzen KP, Sander T, Kunz D and Gallinat J: Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology (Berl). 180:95–99. 2005.PubMed/NCBI View Article : Google Scholar

Monteggia LM, Luikart B, Barrot M, Theobold D, Malkovska I, Nef S, Parada LF and Nestler EJ: Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry. 61:187–197. 2007.PubMed/NCBI View Article : Google Scholar

Duman RS: Pathophysiology of depression: The concept of synaptic plasticity. Eur Psychiatry. 17 (Suppl 3):306–310. 2002.PubMed/NCBI View Article : Google Scholar

Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J, Sun B and Tandon NN: Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost. 87:728–734. 2002.PubMed/NCBI

Lee BH and Kim YK: The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investig. 7:231–235. 2010.PubMed/NCBI View Article : Google Scholar

Pan W, Banks WA, Fasold MB, Bluth J and Kastin AJ: Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 37:1553–1561. 1998.PubMed/NCBI View Article : Google Scholar

Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C and Vahip S: Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci. 255:381–386. 2005.PubMed/NCBI View Article : Google Scholar

Chaudhury D, Liu H and Han MH: Neuronal correlates of depression. Cell Mol Life Sci. 72:4825–4848. 2015.PubMed/NCBI View Article : Google Scholar

Jin Y, Sun LH, Yang W, Cui RJ and Xu SB: The role of BDNF in the neuroimmune axis regulation of mood disorders. Front Neurol. 10(515)2019.PubMed/NCBI View Article : Google Scholar

Jiang MQ, Zhao YY, Cao W, Wei ZZ, Gu X, Wei L and Yu SP: Long-term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice. Brain Pathol. 27:480–498. 2017.PubMed/NCBI View Article : Google Scholar

North RA and Jarvis MF: P2X receptors as drug targets. Mol Pharmacol. 83:759–769. 2013.PubMed/NCBI View Article : Google Scholar

Vázquez-Villoldo N, Domercq M, Martín A, Llop J, Gómez-Vallejo V and Matute C: P2X4 receptors control the fate and survival of activated microglia. Glia. 62:171–184. 2014.PubMed/NCBI View Article : Google Scholar

Verma R, Cronin CG, Hudobenko J, Venna VR, McCullough LD and Liang BT: Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke. Brain Behav Immun. 66:302–312. 2017.PubMed/NCBI View Article : Google Scholar

Bravo-Alegria J, McCullough LD and Liu F: Sex differences in stroke across the lifespan: The role of T lymphocytes. Neurochem Int. 107:127–137. 2017.PubMed/NCBI View Article : Google Scholar

Xu S, Lu J, Shao A, Zhang JH and Zhang J: Glial cells: Role of the immune response in ischemic stroke. Front Immunol. 11(294)2020.PubMed/NCBI View Article : Google Scholar

Zera KA and Buckwalter MS: The Local and peripheral immune responses to stroke: Implications for therapeutic development. Neurotherapeutics: Mar 19, 2020 (Epub ahead of print). doi: 10.1007/s13311-020-00844-3.

Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG and Barres BA: Genomic analysis of reactive astrogliosis. J Neurosci. 32:6391–6410. 2012.PubMed/NCBI View Article : Google Scholar

Zhao X, Wang H, Sun G, Zhang J, Edwards NJ and Aronowski J: Neuronal interleukin-4 as a modulator of microglial pathways and ischemic brain damage. J Neurosci. 35:11281–11291. 2015.PubMed/NCBI View Article : Google Scholar

Lee GA, Lin TN, Chen CY, Mau SY, Huang WZ, Kao YC, Ma RY and Liao NS: Interleukin 15 blockade protects the brain from cerebral ischemia-reperfusion injury. Brain Behav Immun. 73:562–570. 2018.PubMed/NCBI View Article : Google Scholar

Dolati S, Ahmadi M, Khalili M, Taheraghdam AA, Siahmansouri H, Babaloo Z, Aghebati-Maleki L, Jadidi-Niaragh F, Younesi V and Yousefi M: Peripheral Th17/Treg imbalance in elderly patients with ischemic stroke. Neurol Sci. 39:647–654. 2018.PubMed/NCBI View Article : Google Scholar

Santamaría-Cadavid M, Rodríguez-Castro E, Rodríguez-Yáñez M, Arias-Rivas S, López-Dequidt I, Pérez-Mato M, Rodríguez-Pérez M, López-Loureiro I, Hervella P, Campos F, et al: Regulatory T cells participate in the recovery of ischemic stroke patients. BMC Neurol. 20(68)2020.PubMed/NCBI View Article : Google Scholar

Stubbe T, Ebner F, Richter D, Engel O, Klehmet J, Royl G, Meisel A, Nitsch R, Meisel C and Brandt C: Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO. J Cereb Blood Flow Metab. 33:37–47. 2013.PubMed/NCBI View Article : Google Scholar

Liesz A, Zhou W, Mracskó É, Karcher S, Bauer H, Schwarting S, Sun L, Bruder D, Stegemann S, Cerwenka A, et al: Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain. 134:704–720. 2011.PubMed/NCBI View Article : Google Scholar

Doyle KP, Quach LN, Solé M, Axtell RC, Nguyen TV, Soler-Llavina GJ, Jurado S, Han J, Steinman L, Longo FM, et al: B-lymphocyte-mediated delayed cognitive impairment following stroke. J Neurosci. 35:2133–2145. 2015.PubMed/NCBI View Article : Google Scholar

Rayasam A, Hsu M, Hernández G, Kijak J, Lindstedt A, Gerhart C, Sandor M and Fabry Z: Contrasting roles of immune cells in tissue injury and repair in stroke: The dark and bright side of immunity in the brain. Neurochem Int. 107:104–116. 2017.PubMed/NCBI View Article : Google Scholar

Nakamura K and Shichita T: Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke. J Biochem. 165:459–464. 2019.PubMed/NCBI View Article : Google Scholar

Szepesi Z, Manouchehrian O, Bachiller S and Deierborg T: Bidirectional microglia-neuron communication in health and disease. Front Cell Neurosci. 12(323)2018.PubMed/NCBI View Article : Google Scholar

Sharp FR, Zhan X and Liu DZ: Heat shock proteins in the bra in: Role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential. Transl Stroke Res. 4:685–692. 2013.PubMed/NCBI View Article : Google Scholar

Nitti M, Piras S, Brondolo L, Marinari UM, Pronzato MA and Furfaro AL: Heme Oxygenase 1 in the nervous system: Does it favor neuronal cell survival or induce neurodegeneration? Int J Mol Sci. 19(E2260)2018.PubMed/NCBI View Article : Google Scholar

Hermann DM, Kleinschnitz C and Gunzer M: Role of polymorphonuclear neutrophils in the reperfused ischemic brain: Insights from cell-type-specific immunodepletion and fluorescence microscopy studies. Ther Adv Neurol Disord. 11(1756286418798607)2018.PubMed/NCBI View Article : Google Scholar

Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB, Mulinyawe SB, Bohlen CJ, Adil A, Tucker A, et al: New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci USA. 113:E1738–E1746. 2016.PubMed/NCBI View Article : Google Scholar

Zarruk JG, Greenhalgh AD and David S: Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia. Exp Neurol. 301:120–132. 2018.PubMed/NCBI View Article : Google Scholar

Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T and Yoshimura A: MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 23:723–732. 2017.PubMed/NCBI View Article : Google Scholar

Xia CY, Zhang S, Gao Y, Wang ZZ and Chen NH: Selective modulation of microglia polarization to M2 phenotype for stroke treatment. Int Immunopharmacol. 25:377–382. 2015.PubMed/NCBI View Article : Google Scholar

Taj HS, Kho W, Riou A, Wiedermann D and Hoehn M: MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia. Biomaterials. 91:151–165. 2016.PubMed/NCBI View Article : Google Scholar

Liu X, Liu J, Zhao S, Zhang H, Cai W, Cai M, Ji X, Leak RK, Gao Y, Chen J, et al: Interleukin-4 is essential for microglia/macrophage M2 polarization and long-term recovery after cerebral ischemia. Stroke. 47:498–504. 2016.PubMed/NCBI View Article : Google Scholar

Zhou K, Zhong Q, Wang YC, Xiong XY, Meng ZY, Zhao T, Zhu WY, Liao MF, Wu LR, Yang YR, et al: Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis. J Cereb Blood Flow Metab. 37:967–979. 2017.PubMed/NCBI View Article : Google Scholar

Titova EM, Ghosh N, Valadez ZG, Zhang JH, Bellinger DL and Obenaus A: The late phase of post-stroke neurorepair in aged rats is reflected by MRI-based measures. Neuroscience. 283:231–244. 2014.PubMed/NCBI View Article : Google Scholar

Ongür D, Drevets WC and Price JL: Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA. 95:13290–13295. 1998.PubMed/NCBI View Article : Google Scholar

Nimmerjahn A, Kirchhoff F and Helmchen F: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 308:1314–1318. 2005.PubMed/NCBI View Article : Google Scholar

Smith RS: The macrophage theory of depression. Med Hypotheses. 35:298–306. 1991.PubMed/NCBI View Article : Google Scholar

Dey A and Hankey Giblin PA: Insights into macrophage heterogeneity and cytokine-induced neuroinflammation in major Ddepressive disorder. Pharmaceuticals (Basel). 11(E64)2018.PubMed/NCBI View Article : Google Scholar

Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, et al: Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity. 40:274–288. 2014.PubMed/NCBI View Article : Google Scholar

Orecchioni M, Ghosheh Y, Pramod AB and Ley K: Macrophage polarization: Different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. alternatively activated macrophages. Front Immunol. 10(1084)2019.PubMed/NCBI View Article : Google Scholar

Ransohoff RM: A polarizing question: Do M1 and M2 microglia exist? Nat Neurosci. 19:987–991. 2016.PubMed/NCBI View Article : Google Scholar

Eyo UB and Wu LJ: Bidirectional microglia-neuron communication in the healthy brain. Neural Plast. 2013(456857)2013.PubMed/NCBI View Article : Google Scholar

Hayakawa K, Wang X and Lo EH: CD200 increases alternatively activated macrophages through cAMP-response element binding protein-C/EBP-beta signaling. J Neurochem. 136:900–906. 2016.PubMed/NCBI View Article : Google Scholar

Xu T, Pu S, Ni Y, Gao M, Li X and Zeng X: Elevated plasma macrophage migration inhibitor factor as a risk factor for the development of post-stroke depression in ischemic stroke. J Neuroimmunol. 320:58–63. 2018.PubMed/NCBI View Article : Google Scholar

Yang DB, Yu WH, Dong XQ, Zhang ZY, Du Q, Zhu Q, Che ZH, Wang H, Shen YF and Jiang L: Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury. Clin Chim Acta. 469:99–104. 2017.PubMed/NCBI View Article : Google Scholar

Leyton-Jaimes MF, Kahn J and Israelson A: Macrophage migration inhibitory factor: A multifaceted cytokine implicated in multiple neurological diseases. Exp Neurol. 301:83–91. 2018.PubMed/NCBI View Article : Google Scholar

Chen H, Li X, Liu S, Gu L and Zhou X: MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis. Sci Rep. 7(12089)2017.PubMed/NCBI View Article : Google Scholar

Ritzel RM, Patel AR, Grenier JM, Crapser J, Verma R, Jellison ER and McCullough LD: Functional differences between microglia and monocytes after ischemic stroke. J Neuroinflammation. 12(106)2015.PubMed/NCBI View Article : Google Scholar

Meng HL, Li XX, Chen YT, Yu LJ, Zhang H, Lao JM, Zhang X and Xu Y: Neuronal soluble Fas ligand drives M1-Microglia polarization after cerebral ischemia. CNS Neurosci Ther. 22:771–781. 2016.PubMed/NCBI View Article : Google Scholar

Wattananit S, Tornero D, Graubardt N, Memanishvili T, Monni E, Tatarishvili J, Miskinyte G, Ge R, Ahlenius H, Lindvall O, et al: Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice. J Neurosci. 36:4182–4195. 2016.PubMed/NCBI View Article : Google Scholar

Horváth E, Huțanu A, Chiriac L, Dobreanu M, Orădan A and Nagy EE: Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia. J Neuroimmunol. 324:35–42. 2018.PubMed/NCBI View Article : Google Scholar

Brites D and Fernandes A: Neuroinflammation and depression: Microglia activation, extracellular microvesicles and microRNA dysregulation. Front Cell Neurosci. 9(476)2015.PubMed/NCBI View Article : Google Scholar

Mezentsev A, Merks RM, O'Riordan E, Chen J, Mendelev N, Goligorsky MS and Brodsky SV: Endothelial microparticles affect angiogenesis in vitro: Role of oxidative stress. Am J Physiol Heart Circ Physiol. 289:H1106–H1114. 2005.PubMed/NCBI View Article : Google Scholar

Leroyer AS, Ebrahimian TG, Cochain C, Récalde A, Blanc-Brude O, Mees B, Vilar J, Tedgui A, Levy BI, Chimini G, et al: Microparticles from ischemic muscle promotes postnatal vasculogenesis. Circulation. 119:2808–2817. 2009.PubMed/NCBI View Article : Google Scholar

Garzetti L, Menon R, Finardi A, Bergami A, Sica A, Martino G, Comi G, Verderio C, Farina C and Furlan R: Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs. J Leukoc Biol. 95:817–825. 2014.PubMed/NCBI View Article : Google Scholar

Bianco F, Pravettoni E, Colombo A, Schenk U, Möller T, Matteoli M and Verderio C: Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol. 174:7268–7277. 2005.PubMed/NCBI View Article : Google Scholar

Viviani B, Gardoni F, Bartesaghi S, Corsini E, Facchi A, Galli CL, Di Luca M and Marinovich M: Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors. J Biol Chem. 281:30212–30222. 2006.PubMed/NCBI View Article : Google Scholar

Allan SM and Rothwell NJ: Inflammation in central nervous system injury. Philos Trans R Soc Lond B Biol Sci. 358:1669–1677. 2003.PubMed/NCBI View Article : Google Scholar

Grønhøj MH, Clausen BH, Fenger CD, Lambertsen KL and Finsen B: Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke. Brain Behav Immun. 65:296–311. 2017.PubMed/NCBI View Article : Google Scholar

Anderson G, Kubera M, Duda W, Lasoń W, Berk M and Maes M: Increased IL-6 trans-signaling in depression: Focus on the tryptophan catabolite pathway, melatonin and neuroprogression. Pharmacol Rep. 65:1647–1654. 2013.PubMed/NCBI View Article : Google Scholar

Zou JY and Crews FT: TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: Neuroprotection by NF kappa B inhibition. Brain Res. 1034:11–24. 2005.PubMed/NCBI View Article : Google Scholar

Zeng L, Wang Y, Liu J, Wang L, Weng S, Chen K, Domino EF and Yang GY: Pro-inflammatory cytokine network in peripheral inflammation response to cerebral ischemia. Neurosci Lett. 548:4–9. 2013.PubMed/NCBI View Article : Google Scholar

Kaminska B: MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta. 1754:253–262. 2005.PubMed/NCBI View Article : Google Scholar

Hetman M and Gozdz A: Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem. 271:2050–2055. 2004.PubMed/NCBI View Article : Google Scholar

Subramaniam S and Unsicker K: ERK and cell death: ERK1/2 in neuronal death. FEBS J. 277:22–29. 2010.PubMed/NCBI View Article : Google Scholar

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, et al: Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 556:332–338. 2018.PubMed/NCBI View Article : Google Scholar

Schiepers OJG, Wichers MC and Maes M: Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry. 29:201–217. 2005.PubMed/NCBI View Article : Google Scholar

Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK and Lanctôt KL: A meta-analysis of cytokines in major depression. Biol Psychiatry. 67:446–457. 2010.PubMed/NCBI View Article : Google Scholar

Liu Y, Ho RCM and Mak A: The role of interleukin (IL)-17 in anxiety and depression of patients with rheumatoid arthritis. Int J Rheum Dis. 15:183–187. 2012.PubMed/NCBI View Article : Google Scholar

Su JA, Chou SY, Tsai CS and Hung TH: Cytokine changes in the pathophysiology of poststroke depression. Gen Hosp Psychiatry. 34:35–39. 2012.PubMed/NCBI View Article : Google Scholar

Yirmiya R, Rimmerman N and Reshef R: Depression as a microglial disease. Trends Neurosci. 38:637–658. 2015.PubMed/NCBI View Article : Google Scholar

Myint AM, Kim YK, Verkerk R, Scharpé S, Steinbusch H and Leonard B: Kynurenine pathway in major depression: Evidence of impaired neuroprotection. J Affect Disord. 98:143–151. 2007.PubMed/NCBI View Article : Google Scholar

Tilleux S and Hermans E: Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res. 85:2059–2070. 2007.PubMed/NCBI View Article : Google Scholar

Tavares RG, Tasca CI, Santos CE, Alves LB, Porciúncula LO, Emanuelli T and Souza DO: Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem Int. 40:621–627. 2002.PubMed/NCBI View Article : Google Scholar

Miller AH, Maletic V and Raison CL: Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 65:732–741. 2009.PubMed/NCBI View Article : Google Scholar

Salazar-Colocho P, Del Río J and Frechilla D: Neuroprotective effects of serotonin 5-HT 1A receptor activation against ischemic cell damage in gerbil hippocampus: Involvement of NMDA receptor NR1 subunit and BDNF. Brain Res. 1199:159–166. 2008.PubMed/NCBI View Article : Google Scholar

Davami MH, Baharlou R, Ahmadi Vasmehjani A, Ghanizadeh A, Keshtkar M, Dezhkam I and Atashzar MR: Elevated IL-17 and TGF-β serum levels: A positive correlation between T-helper 17 cell-related pro-inflammatory responses with major depressive disorder. Basic Clin Neurosci. 7:137–142. 2016.PubMed/NCBI View Article : Google Scholar

Beurel E, Harrington LE and Jope RS: Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol Psychiatry. 73:622–630. 2013.PubMed/NCBI View Article : Google Scholar

Li HL, Kostulas N, Huang YM, Xiao BG, van der Meide P, Kostulas V, Giedraitas V and Link H: IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat. J Neuroimmunol. 116:5–14. 2001.PubMed/NCBI View Article : Google Scholar

Zhang J, Mao X, Zhou T, Cheng X and Lin Y: IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice. Neuroscience. 274:419–428. 2014.PubMed/NCBI View Article : Google Scholar

Kichev A, Rousset CI, Baburamani AA, Levison SW, Wood TL, Gressens P, Thornton C and Hagberg H: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. J Biol Chem. 289:9430–9439. 2014.PubMed/NCBI View Article : Google Scholar

Heymann MF, Herisson F, Davaine JM, Charrier C, Battaglia S, Passuti N, Lambert G, Gouëffic Y and Heymann D: Role of the OPG/RANK/RANKL triad in calcifications of the atheromatous plaques: Comparison between carotid and femoral beds. Cytokine. 58:300–306. 2012.PubMed/NCBI View Article : Google Scholar

Nagy EE, Varga-Fekete T, Puskas A, Kelemen P, Brassai Z, Szekeres-Csiki K, Gombos T, Csanyi MC and Harsfalvi J: High circulating osteoprotegerin levels are associated with non-zero blood groups. BMC Cardiovasc Disord. 16(106)2016.PubMed/NCBI View Article : Google Scholar

Shimamura M, Nakagami H, Osako MK, Kurinami H, Koriyama H, Zhengda P, Tomioka H, Tenma A, Wakayama K and Morishita R: OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci USA. 111:8191–8196. 2014.PubMed/NCBI View Article : Google Scholar

Kim HY and Han SH: Matrix metalloproteinases in cerebral ischemia. J Clin Neurol. 2:163–170. 2006.PubMed/NCBI View Article : Google Scholar

Anuncibay-Soto B, Pérez-Rodriguez D, Santos-Galdiano M, Font-Belmonte E, Ugidos IF, Gonzalez-Rodriguez P, Regueiro-Purriños M and Fernández-López A: Salubrinal and robenacoxib treatment after global cerebral ischemia. Exploring the interactions between ER stress and inflammation. Biochem Pharmacol. 151:26–37. 2018.PubMed/NCBI View Article : Google Scholar

Ugidos IF, Santos-Galdiano M, Pérez-Rodríguez D, Anuncibay-Soto B, Font-Belmonte E, López DJ, Ibarguren M, Busquets X and Fernández-López A: Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion. Biochim Biophys Acta Biomembr. 1859:1648–1656. 2017.PubMed/NCBI View Article : Google Scholar

De los Reyes LM and Céspedes AE: Atorvastatin-meloxicam association inhibits neuroinflammation and attenuates the cellular damage in cerebral ischemia by arterial embolism. Biomedica. 34:366–378. 2014.PubMed/NCBI View Article : Google Scholar : (In Spanish).

Llorente IL, Landucci E, Pellegrini-Giampietro DE and Fernández-López A: Glutamate receptor and transporter modifications in rat organotypic hippocampal slice cultures exposed to oxygen-glucose deprivation: The contribution of cyclooxygenase-2. Neuroscience. 292:118–128. 2015.PubMed/NCBI View Article : Google Scholar

Nagy E, Vajda E, Vari C, Sipka S, Fárr AM and Horváth E: Meloxicam ameliorates the cartilage and subchondral bone deterioration in monoiodoacetate-induced rat osteoarthritis. PeerJ. 5(e3185)2017.PubMed/NCBI View Article : Google Scholar

Arafa HM, Abdel-Wahab MH, El-Shafeey MF, Badary OA and Hamada FM: Anti-fibrotic effect of meloxicam in a murine lung fibrosis model. Eur J Pharmacol. 564:181–189. 2007.PubMed/NCBI View Article : Google Scholar

Hassan MH and Ghobara MM: Antifibrotic effect of meloxicam in rat liver: Role of nuclear factor kappa B, proinflammatory cytokines, and oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 389:971–983. 2016.PubMed/NCBI View Article : Google Scholar

Honma S, Shinohara M, Takahashi N, Nakamura K, Hamano S, Mitazaki S, Abe S and Yoshida M: Effect of cyclooxygenase (COX)-2 inhibition on mouse renal interstitial fibrosis. Eur J Pharmacol. 740:578–583. 2014.PubMed/NCBI View Article : Google Scholar

Csifo E, Nagy EE, Horvath E, Farr A and Muntean DL: Mid-term effects of meloxicam on collagen type II degradation in a rat osteoarthritis model induced by iodoacetate. Farmacia. 63:556–560. 2015.

Sabogal-Guáqueta AM, Posada-Duque R, Cortes NC, Arias-Londoño JD and Cardona-Gómez GP: Changes in the hippocampal and peripheral phospholipid profiles are associated with neurodegeneration hallmarks in a long-term global cerebral ischemia model: Attenuation by Linalool. Neuropharmacology. 135:555–571. 2018.PubMed/NCBI View Article : Google Scholar

Horváth E, Oradan A and Chiriac L: Dobreanu M, Nagy EE, Voidăzan S, Berei R, Muntean DL and Hutanu A: Fish-oil preconditioning upregulates expression of splenic Arg1 positive M2 type macrophags and the Arg1/iNos2 ratio after experimental induced transient cerebral ischemia. Farmacia. 67:820–829. 2019.

Horvath E, Hutanu A, Oradan A, Chiriac L, Muntean DL, Nagy EE and Dobreanu M: N-3 polyunsaturated fatty acids induce granulopoiesis and early monocyte polarization in the bone marrow of a tMCAO rat model. Rev Rom Med Lab. 27:51–61. 2019.

Pentón-Rol G, Marín-Prida J and Falcón-Cama V: C-phycocyanin and phycocyanobilin as remyelination therapies for enhancing recovery in multiple sclerosis and ischemic stroke: A preclinical perspective. Behav Sci (Basel). 8(E158)2018.PubMed/NCBI View Article : Google Scholar

Alawieh A, Elvington A, Zhu H, Yu J, Kindy MS, Atkinson C and Tomlinson S: Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement. J Neuroinflammation. 12(247)2015.PubMed/NCBI View Article : Google Scholar

Kopschina Feltes P, Doorduin J, Klein HC, Juárez-Orozco LE, Dierckx RA, Moriguchi-Jeckel CM and de Vries EF: Anti-inflammatory treatment for major depressive disorder: Implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy. J Psychopharmacol. 31:1149–1165. 2017.PubMed/NCBI View Article : Google Scholar

Akhondzadeh S, Jafari S, Raisi F, Nasehi AA, Ghoreishi A, Salehi B, Mohebbi-Rasa S, Raznahan M and Kamalipour A: Clinical trial of adjunctive celecoxib treatment in patients with major depression: A double blind and placebo controlled trial. Depress Anxiety. 26:607–611. 2009.PubMed/NCBI View Article : Google Scholar

Abbasi SH, Hosseini F, Modabbernia A, Ashrafi M and Akhondzadeh S: Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study. J Affect Disord. 141:308–314. 2012.PubMed/NCBI View Article : Google Scholar

Tyring S, Gottlieb A, Papp K, Gordon K, Leonardi C, Wang A, Lalla D, Woolley M, Jahreis A, Zitnik R, et al: Etanercept and clinical outcomes, fatigue, and depression in psoriasis: Double-blind placebo-controlled randomised phase III trial. Lancet. 367:29–35. 2006.PubMed/NCBI View Article : Google Scholar

Nemeth CL, Glasper ER, Harrell CS, Malviya SA, Otis JS and Neigh GN: Meloxicam blocks neuroinflammation, but not depressive-like behaviors, in HIV-1 transgenic female rats. PLoS One. 9(e108399)2014.PubMed/NCBI View Article : Google Scholar

Liu J, Nolte K, Brook G, Liebenstund L, Weinandy A, Höllig A, Veldeman M, Willuweit A, Langen KJ, Rossaint R, et al: Post-stroke treatment with argon attenuated brain injury, reduced brain inflammation and enhanced M2 microglia/macrophage polarization: A randomized controlled animal study. Crit Care. 23(198)2019.PubMed/NCBI View Article : Google Scholar