Glucagonoma: From skin lesions to the neuroendocrine component (Review)

  • Authors:
    • Florica Sandru
    • Mara Carsote
    • Simona Elena Albu
    • Ana Valea
    • Aida Petca
    • Mihai Cristian Dumitrascu
  • View Affiliations

  • Published online on: July 3, 2020     https://doi.org/10.3892/etm.2020.8966
  • Pages: 3389-3393
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Abstract

Glucagonoma is a hormonally active rare pancreatic neuroendocrine tumour causing an excess of glucagon. This is a narrative review based on a multidisciplinary approach of the tumour. Typically associated dermatosis is necrolytic migratory erythema (NME) which is most frequently seen at disease onset. Insulin‑dependent diabetes mellitus, depression, diarrhoea, deep vein thrombosis are also identified, as parts of so‑called ‘D’ syndrome. Early diagnosis is life saving due to potential aggressive profile and high risk of liver metastasis. NME as paraneoplastic syndrome may be present for months and even years until adequate recognition and therapy; it is remitted after successful pancreatic surgery. Thus the level of practitioners' awareness is essential. If surgery is not curative, debulking techniques may improve the clinical aspects and even the outcome in association with other procedures such as embolization of hepatic metastasis; ablation of radiofrequency type; medical therapy including chemotherapy, targeted therapy with mTOR inhibitors such as everolimus, PRRT (peptide receptor radiotherapy), and somatostatin analogues (including combinations of medical treatments). Increased awareness of the condition involves multidisciplinary practitioners.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sandru F, Carsote M, Albu SE, Valea A, Petca A and Dumitrascu MC: Glucagonoma: From skin lesions to the neuroendocrine component (Review). Exp Ther Med 20: 3389-3393, 2020.
APA
Sandru, F., Carsote, M., Albu, S.E., Valea, A., Petca, A., & Dumitrascu, M.C. (2020). Glucagonoma: From skin lesions to the neuroendocrine component (Review). Experimental and Therapeutic Medicine, 20, 3389-3393. https://doi.org/10.3892/etm.2020.8966
MLA
Sandru, F., Carsote, M., Albu, S. E., Valea, A., Petca, A., Dumitrascu, M. C."Glucagonoma: From skin lesions to the neuroendocrine component (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 3389-3393.
Chicago
Sandru, F., Carsote, M., Albu, S. E., Valea, A., Petca, A., Dumitrascu, M. C."Glucagonoma: From skin lesions to the neuroendocrine component (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3389-3393. https://doi.org/10.3892/etm.2020.8966