Proteus syndrome of the foot: A case report and literature review

He,Min; Zhao,Weijia

doi:10.3892/etm.2020.8986

Proteus syndrome of the foot: A case report and literature review

Authors:
- Min He
- Weijia Zhao
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Affiliations: Department of Dermatology, The 59th Central Hospital of the People's Liberation Army, Kaiyuan, Yunnan 661699, P.R. China, Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China
Published online on: July 10, 2020 https://doi.org/10.3892/etm.2020.8986
Pages: 2716-2720
Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Proteus syndrome (PS) is an extremely rare and sporadic disorder characterized by asymmetric and/or disproportionate overgrowth of limbs, hamartomas, and vascular malformations. The onset of overgrowth usually involves the skin, bone, fat, and other connective tissues in a patchy or mosaic pattern. Partial gigantism of the affected limb or digit is a pathognomonic sign of PS. Thus far, only a few cases of PS have been recorded in the literature. In the present report, a case of PS in a 35‑year old woman with classic cerebriform plantar hyperplasia and macrodactyly of the left foot was documented. The clinical and molecular characteristics and differential diagnosis of PS are also discussed in this report.

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