Open Access

Development of a novel rat model of lumbar facet joint osteoarthritis induced by persistent compressive injury

  • Authors:
    • You Lu
    • Shishen Pei
    • Shuxun Hou
  • View Affiliations

  • Published online on: August 7, 2020     https://doi.org/10.3892/etm.2020.9117
  • Pages: 3740-3748
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to develop a novel animal model of lumbar facet joint osteoarthritis induced by persistent compressive injury. An intraspinal compression spring was randomly implanted into either the L4/5 or the L5/6 spinal segments of 40 Sprague Dawley (SD) rats to induce compression. Sham‑operations were used in the other segment of the same rats as the control levels. The animals were sacrificed at 7, 14, 28, 42 and 56 days after surgery, prior to the radiological confirmation of the spring location. Degeneration of the lumbar facet joints was evaluated by macroscopic observation in addition to histological and immunohistological analyses. The results of this present study revealed the absence of spring dislocation during the entire observation period. Macroscopic and Osteoarthritis Research Society International scores of the compression levels were found to be higher in the compression levels compared with those noted in the control levels (P<0.05). In addition, interleukin‑1β and tumor necrosis factor‑α expression in the compression levels were increased over time compared with those recorded in the control levels. In conclusion, persistent compressive injury may induce degeneration of the lumbar facet joint. This novel animal model could serve as a useful tool for further studies into the mechanisms of action and potential treatment of lumbar facet joint osteoarthritis.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lu Y, Pei S and Hou S: Development of a novel rat model of lumbar facet joint osteoarthritis induced by persistent compressive injury. Exp Ther Med 20: 3740-3748, 2020.
APA
Lu, Y., Pei, S., & Hou, S. (2020). Development of a novel rat model of lumbar facet joint osteoarthritis induced by persistent compressive injury. Experimental and Therapeutic Medicine, 20, 3740-3748. https://doi.org/10.3892/etm.2020.9117
MLA
Lu, Y., Pei, S., Hou, S."Development of a novel rat model of lumbar facet joint osteoarthritis induced by persistent compressive injury". Experimental and Therapeutic Medicine 20.4 (2020): 3740-3748.
Chicago
Lu, Y., Pei, S., Hou, S."Development of a novel rat model of lumbar facet joint osteoarthritis induced by persistent compressive injury". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3740-3748. https://doi.org/10.3892/etm.2020.9117