Comparison of the effectiveness and safety of travoprost and latanoprost for the management of open‑angle glaucoma given as an evening dose

  • Authors:
    • Jing Li
    • Xiaoyi Wang
    • Guihua Xu
    • Ruidong Deng
    • Laiwei Wu
    • Liqin Zhang
    • Zilin Chen
  • View Affiliations

  • Published online on: August 28, 2020     https://doi.org/10.3892/etm.2020.9152
  • Article Number: 24
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Abstract

As intraocular pressure (IOP) is primarily higher in the morning, an evening dose of prostaglandin analogs is typically used as monotherapy to decrease IOP in patients with open‑angle glaucoma. Travoprost (TV) has reported efficacy in treating open‑angle glaucoma; however, the safety and efficacy may be different compared with that for latanoprost (LT). The aim of the present study was to compare the effectiveness and safety of an evening dose of TV compared with that of LT in treating open‑angle glaucoma. Data including IOP, results of lid and slit‑lamp examination and ophthalmoscopy, as well as adverse effects in 250 affected eyes from patients with open‑angle glaucoma who received either TV (n=89) or LT (n=161) once in the evening for 3‑months were included in the analyses. At the end of treatment, TV (23.45±1.52 vs. 19.15±1.01 mmHg; P<0.0001) and LT (23.93±2.11 vs. 19.45±1.11 mmHg; P<0.0001) successfully lowered the IOP. In addition, there was no significant difference in the reduction of IOP values at the end of treatment between the two groups (P=0.120). Furthermore, there were no adverse effects on visual acuity (P>0.05), except for non‑visual acuity, for example hyperemia (P<0.0001 for both groups), while there was a significant increase in the number of patients with dry eyes receiving TV (P=0.020) and a significant increase with eyelid swelling (P=0.036) and headache (P=0.037) in patients receiving LT. In conclusion, evening doses of TV and LT had the same efficacy and manageable adverse effects in the treatment of open‑angle glaucoma (level of evidence, 3).
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li J, Wang X, Xu G, Deng R, Wu L, Zhang L and Chen Z: Comparison of the effectiveness and safety of travoprost and latanoprost for the management of open‑angle glaucoma given as an evening dose. Exp Ther Med 20: 24, 2020.
APA
Li, J., Wang, X., Xu, G., Deng, R., Wu, L., Zhang, L., & Chen, Z. (2020). Comparison of the effectiveness and safety of travoprost and latanoprost for the management of open‑angle glaucoma given as an evening dose. Experimental and Therapeutic Medicine, 20, 24. https://doi.org/10.3892/etm.2020.9152
MLA
Li, J., Wang, X., Xu, G., Deng, R., Wu, L., Zhang, L., Chen, Z."Comparison of the effectiveness and safety of travoprost and latanoprost for the management of open‑angle glaucoma given as an evening dose". Experimental and Therapeutic Medicine 20.5 (2020): 24.
Chicago
Li, J., Wang, X., Xu, G., Deng, R., Wu, L., Zhang, L., Chen, Z."Comparison of the effectiveness and safety of travoprost and latanoprost for the management of open‑angle glaucoma given as an evening dose". Experimental and Therapeutic Medicine 20, no. 5 (2020): 24. https://doi.org/10.3892/etm.2020.9152