Open Access

Diagnostic efficacy of intravascular ultrasound combined with Gd2O3‑EPL contrast agent for patients with atherosclerosis

  • Authors:
    • Shuangli Zhu
    • Chaoyang Wen
    • Dongxue Bai
    • Meiying Gao
  • View Affiliations

  • Published online on: October 2, 2020     https://doi.org/10.3892/etm.2020.9265
  • Article Number: 136
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Atherosclerosis is a cardiovascular disease that is pathologically associated with the growth of atherosclerotic plaques and vascular vulnerability. Intravascular ultrasound (IVUS) has been used to evaluate and treat cardiovascular diseases. Accumulating evidence has demonstrated that Gd2O3‑doped nanoparticles contrast can be applied for the diagnosis of human diseases. In the present study, eplerenone (EPL), a mineralocorticoid receptor antagonist, was first doped with Gd2O3 nanoparticles (Gd2O3‑EPL), following which its diagnostic efficacy for use in IVUS measurements (Gd2O3‑EPL‑IVUS) was evaluated for patients suspected with atherosclerosis. Gd2O3‑EPL‑IVUS presented with higher accuracy and sensitivity compared with IVUS in diagnosing 188 patients with suspected atherosclerosis. Gd2O3‑EPL‑IVUS exhibited stronger signals associated with plaque morphology compared with aloe IVUS for patients with atherosclerosis. In addition, Gd2O3‑EPL‑IVUS application resulted in clearer arterial plaque images compared with IVUS by binding mineralocorticoid receptors. Atherosclerosis was subsequently confirmed in all patients using computerized tomography‑coronary angiography. Gd2O3‑EPL‑IVUS showed more accuracy in measuring vessel size, plaque burden and minimal lumen area compared with IVUS analysis alone. In conclusion, these outcomes suggest that Gd2O3‑EPL‑IVUS is a reliable tool for the evaluation of coronary lesions in patients with atherosclerosis.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhu S, Wen C, Bai D and Gao M: Diagnostic efficacy of intravascular ultrasound combined with Gd2O3‑EPL contrast agent for patients with atherosclerosis. Exp Ther Med 20: 136, 2020
APA
Zhu, S., Wen, C., Bai, D., & Gao, M. (2020). Diagnostic efficacy of intravascular ultrasound combined with Gd2O3‑EPL contrast agent for patients with atherosclerosis. Experimental and Therapeutic Medicine, 20, 136. https://doi.org/10.3892/etm.2020.9265
MLA
Zhu, S., Wen, C., Bai, D., Gao, M."Diagnostic efficacy of intravascular ultrasound combined with Gd2O3‑EPL contrast agent for patients with atherosclerosis". Experimental and Therapeutic Medicine 20.6 (2020): 136.
Chicago
Zhu, S., Wen, C., Bai, D., Gao, M."Diagnostic efficacy of intravascular ultrasound combined with Gd2O3‑EPL contrast agent for patients with atherosclerosis". Experimental and Therapeutic Medicine 20, no. 6 (2020): 136. https://doi.org/10.3892/etm.2020.9265