Open Access

Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts

  • Authors:
    • Mengbi Lin
    • Yue Zheng
    • Qian Li
    • Yufang Liu
    • Qingfang Xu
    • Yuying Li
    • Wei Lai
  • View Affiliations

  • Published online on: October 9, 2020     https://doi.org/10.3892/etm.2020.9292
  • Article Number: 163
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) have been previously implicated in number of diseases. However, the roles of circRNAs in photoaging remain elusive. In the present study, to understand if photoaging influences the levels of circRNA expression, the expression of circRNAs in ultraviolet A (UVA)‑irradiated human dermal fibroblasts were profiled. A total of 128 circRNAs were identified to be differentially expressed (fold change >1.5; P<0.05) after UVA exposure, including 39 upregulated and 89 downregulated circRNAs. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes biological pathway analyses indicated that the differentially expressed circRNAs were associated with extracellular matrix organization and metabolism. The present study revealed an altered circRNA expression pattern in human dermal fibroblasts following UVA‑irradiation. These results provide not only a basis for in‑depth study of the mechanism of skin photoaging but also a new possibility for the prevention and treatment of photoaging and associated skin diseases.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Lin M, Zheng Y, Li Q, Liu Y, Xu Q, Li Y and Lai W: Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts. Exp Ther Med 20: 163, 2020.
APA
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., & Lai, W. (2020). Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts. Experimental and Therapeutic Medicine, 20, 163. https://doi.org/10.3892/etm.2020.9292
MLA
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., Lai, W."Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts". Experimental and Therapeutic Medicine 20.6 (2020): 163.
Chicago
Lin, M., Zheng, Y., Li, Q., Liu, Y., Xu, Q., Li, Y., Lai, W."Circular RNA expression profiles significantly altered in UVA‑irradiated human dermal fibroblasts". Experimental and Therapeutic Medicine 20, no. 6 (2020): 163. https://doi.org/10.3892/etm.2020.9292