Neuroendocrine syndrome in bronchial carcinoid tumors

Savu,Cornel; Melinte,Alexandru; Lukadi,Joseph Lula; Mirvald,Cristian; Savu,Carmen; Belu,Emil; Diaconu,Camelia; Iliescu,Laura; Balescu,Irina; Stiru,Ovidiu; Bratu,Ovidiu; Gorecki,Gabriel; Bacalbasa,Nicolae

doi:10.3892/etm.2020.9330

Neuroendocrine syndrome in bronchial carcinoid tumors

Authors:
- Cornel Savu
- Alexandru Melinte
- Joseph Lula Lukadi
- Cristian Mirvald
- Carmen Savu
- Emil Belu
- Camelia Diaconu
- Laura Iliescu
- Irina Balescu
- Ovidiu Stiru
- Ovidiu Bratu
- Gabriel Gorecki
- Nicolae Bacalbasa
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Affiliations: Department of Thoracic Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Thoracic Surgery, ‘Marius Nasta’ National Institute of Pneumophtisiology, 050159 Bucharest, Romania, Department of Urology, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania, Department of Anesthesiology, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania, Department of Oncology, ‘Prof. Dr. Al. Trestioreanu’ Institute of Oncology, 022328 Bucharest, Romania, Department of Internal Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Visceral Surgery, ‘Ponderas’ Academic Hospital, 021188 Bucharest, Romania, Department of Cardiac Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Anaesthesia and Intensive Care, ‘Ilfov’ County Emergency Hospital, 022104 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
Published online on: October 14, 2020 https://doi.org/10.3892/etm.2020.9330
Article Number: 200

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Abstract

Pulmonary carcinoid tumors represent bronchopulmonary neuroendocrine neoplasms which might synthetize serotonin, histamine, bombesin or other types of hormones responsible for the development of a broad spectrum of signs and symptoms, known as carcinoid syndrome. Data of 98 patients submitted to surgery for bronchial carcinoid tumors in the Thoracic Surgery Clinic of the ‘Marius Nasta’ Institute of Pneumophtisiology between 2014 and 2018 were retrospectively reviewed. All patients were submitted to paraclinical tests, imagistic studies (computed tomography or magnetic resonance imaging), bronchoscopy and biopsy in order to have a positive diagnostic of pulmonary carcinoid. The most common clinical symptoms at the time of presentation were: Persistent cough followed by dyspnea and recurrent pulmonary infections. The main neuroendocrine syndromes found were Cushing and Carcinoid Syndrome. All patients were submitted to surgery with curative intent consisting of wedge resection (in 4 cases, 4.08%), lobectomy (in 79 cases, 80.61%), bilobectomy (in 5 cases, 5.1%) and pneumonectomy respectively (in 10 cases, 10.2%). In all cases neuroendocrine specific symptoms disappeared once the carcinoid tumor was removed. In conclusion, bronchial carcinoid tumors have a positive outcome in most cases. Specific neuroendocrine markers as well as neuroendocrine syndrome disappears once the tumor is removed.

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