Influence of cataract surgery on macular vascular density in patients with myopia using optical coherence tomography angiography

Li,Tingting; Guadie,Awoke; Feng,Le; Fan,Jianwu; Jiang,Ziyuan; Liu,Fang

doi:10.3892/etm.2020.9388

Influence of cataract surgery on macular vascular density in patients with myopia using optical coherence tomography angiography

Authors:
- Tingting Li
- Awoke Guadie
- Le Feng
- Jianwu Fan
- Ziyuan Jiang
- Fang Liu
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Affiliations: Department of Ophthalmology, 10th People's Hospital Affiliated to Tongji University, Shanghai 200072, P.R. China, Department of Biology, College of Natural Sciences, Arba Minch University, 21 Arba Minch, Ethiopia, Department of Ophthalmology, Clinical Medical College of Shanghai 10th People's Hospital of Nanjing Medical University, Shanghai 200072, P.R. China
Published online on: October 27, 2020 https://doi.org/10.3892/etm.2020.9388
Article Number: 258

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Abstract

The aim of the present study was to evaluate macular vascular density (MVD) variation after uneventful cataract surgery using optical coherence tomography angiography (OCTA) in patients with high myopia. Patients with cataracts scheduled for cataract surgery were divided into a high‑myopia group [spherical equivalent (SE)≤‑6.0 diopter (D) and axial length (AL)≥25 mm] and a low‑myopia group (SE>‑6.0 D and AL<25 mm). All patients were examined for MVD and retinal thickness (RT) with OCTA pre‑operatively and post‑operatively (1 day, 1 week, and 1 and 3 months after surgery). A total of 55 eyes from 44 patients were included. MVD and RT both changed after cataract surgery. The mean change in superficial vascular density (SVD) in patients with high myopia was significantly lower than that in the low‑myopia group at the four post‑operative time‑points (all P<0.05). In addition, the RT of eyes with high myopia exhibited a different variation compared with that of the low‑myopia group. Significant correlations were identified between AL, RT, intraocular pressure and SVD after surgery. In conclusion, superficial retinal perfusion in patients with high myopia was significantly lower than that in low myopia patients, which may lead to complications caused by poor perfusion.

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1	Eom SY, Yim DH, Kim JH, Chae JB, Kim YD and Kim H: A pilot exome-wide association study of age-related cataract in Koreans. J Biomed Res. 30:186–190. 2016.PubMed/NCBI View Article : Google Scholar
2	Mohammadi A, Khorasani N, Moloudi F and Ghasemi-Rad M: Evaluation of retrobulbar blood flow in patients with age-related cataract; color Doppler ultrasonographic findings. Clin Ophthalmol. 5:1521–1524. 2011.PubMed/NCBI View Article : Google Scholar
3	Emeriewen K, Kadare S, Tsatsos M, Athanasiadis Y, MacGregor C and Rassam S: Non-arteritic anterior ischaemic optic neuropathy after uneventful cataract extraction. Neuroophthalmology. 40:225–228. 2016.PubMed/NCBI View Article : Google Scholar
4	Al-Madani MV, Al-Raqqad NK, Al-Fgarra NA, Al-Thawaby AM and Jaafar AA: The risk of ischemic optic neuropathy post phacoemulsification cataract surgery. Pan Afr Med J. 28(53)2017.PubMed/NCBI View Article : Google Scholar
5	Mo J, Duan A, Chan S, Wang X and Wei W: Vascular flow density in pathological myopia: An optical coherence tomography angiography study. BMJ Open. 7(e013571)2017.PubMed/NCBI View Article : Google Scholar
6	Ng DS, Cheung CY, Luk FO, Mohamed S, Brelen ME, Yam JC, Tsang CW and Lai TY: Advances of optical coherence tomography in myopia and pathologic myopia. Eye (Lond). 30:901–916. 2016.PubMed/NCBI View Article : Google Scholar
7	Fan H, Chen HY, Ma HJ, Chang Z, Yin HQ, Ng DS, Cheung CY, Hu S, Xiang X, Tang SB and Li SN: Reduced macular vascular density in myopic eyes. Chin Med J (Engl). 130:445–451. 2017.PubMed/NCBI View Article : Google Scholar
8	Benavente-Pérez A, Hosking SL, Logan NS and Broadway DC: Ocular blood flow measurements in healthy human myopic eyes. Graefes Arch Clin Exp Ophthalmol. 248:1587–1594. 2010.PubMed/NCBI View Article : Google Scholar
9	Wang X, Kong X, Jiang C, Li M, Yu J and Sun X: Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study. BMJ Open. 6(e010791)2016.PubMed/NCBI View Article : Google Scholar
10	Nagiel A, Sadda SR and Sarraf D: A promising future for optical coherence tomography angiography. JAMA Ophthalmol. 133:629–630. 2015.PubMed/NCBI View Article : Google Scholar
11	Jia Y, Bailey ST, Hwang TS, McClintic SM, Gao SS, Pennesi ME, Flaxel CJ, Lauer AK, Wilson DJ, Hornegger J, et al: Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci USA. 112:E2395–E2402. 2015.PubMed/NCBI View Article : Google Scholar
12	Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D and Wu SY: The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol. 111:831–836. 1993.PubMed/NCBI View Article : Google Scholar
13	Curtin BJ: The posterior staphyloma of pathologic myopia. Trans Am Ophthalmol Soc. 75:67–86. 1977.PubMed/NCBI
14	Friedel JE, DeHart WB, Foreman AM and Andrew ME: A Monte Carlo method for comparing generalized estimating equations to conventional statistical techniques for discounting data. J Exp Anal Behav. 111:207–224. 2019.PubMed/NCBI View Article : Google Scholar
15	Azizi B, Wong T, Wan J, Singer S and Hudson C: The impact of cataract on the quantitative, non-invasive assessment of retinal blood flow. Acta Ophthalmol. 90:e9–e12. 2012.PubMed/NCBI View Article : Google Scholar
16	Spaide RF, Klancnik JM Jr and Cooney MJ: Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 133:45–50. 2015.PubMed/NCBI View Article : Google Scholar
17	Mastropasqua R, Di Antonio L, Di Staso S, Agnifili L, Di Gregorio A, Ciancaglini M and Mastropasqua L: Optical Coherence tomography angiography in retinal vascular diseases and choroidal neovascularization. J Ophthalmol. 2015(343515)2015.PubMed/NCBI View Article : Google Scholar
18	Chalam KV and Sambhav K: Optical coherence tomography angiography in retinal diseases. J Ophthalmic Vis Res. 11:84–92. 2016.PubMed/NCBI View Article : Google Scholar
19	Agemy SA, Scripsema NK, Shah CM, Chui T, Garcia PM, Lee JG, Gentile RC, Hsiao YS, Zhou Q, Ko T and Rosen RB: Retinal vascular perfusion density mapping using optical coherence tomography angiography in normals and diabetic retinopathy patients. Retina. 35:2353–2363. 2015.PubMed/NCBI View Article : Google Scholar
20	Yarmohammadi A, Zangwill LM, Manalastas PIC, Fuller NJ, Diniz-Filho A, Saunders LJ, Suh MH, Hasenstab K and Weinreb RN: Peripapillary and macular vessel density in patients with primary open-angle glaucoma and unilateral visual field loss. Ophthalmology. 125:578–587. 2018.PubMed/NCBI View Article : Google Scholar
21	Gharbiya M, Cruciani F, Cuozzo G, Parisi F, Russo P and Abdolrahimzadeh S: Macular thickness changes evaluated with spectral domain optical coherence tomography after uncomplicated phacoemulsification. Eye (Lond). 27:605–611. 2013.PubMed/NCBI View Article : Google Scholar
22	Grzybowski A, Sikorski BL, Ascaso FJ and Huerva V: Pseudophakic cystoid macular edema: Update 2016. Clin Interv Aging. 11:1221–1229. 2016.PubMed/NCBI View Article : Google Scholar
23	Yu J, Gu R, Zong Y, Xu H, Wang X, Sun X, Jiang C, Xie B, Jia Y and Huang D: Relationship between retinal perfusion and retinal thickness in healthy subjects: An optical coherence tomography angiography study. Invest Ophthalmol Vis Sci. 57:OCT204–OCT210. 2016.
24	Hilton EJ, Hosking SL, Gherghel D, Embleton S and Cunliffe IA: Beneficial effects of small-incision cataract surgery in patients demonstrating reduced ocular blood flow characteristics. Eye (Lond). 19:670–675. 2005.
25	Turk A, Mollamehmetoglu S, Imamoglu HI, Kola M, Erdol H and Akyol N: Effects of phacoemulsification surgery on ocular hemodynamics. Int J Ophthalmol. 6:537–541. 2013.
26	Šiško K, Knez NK and Pahor D: Influence of cataract surgery on macular thickness: A 6-month follow-up. Wien Klin Wochenschr. 127 (Suppl 5):S169–S174. 2015.
27	Zhao Z, Wen W, Jiang C and Lu Y: Changes in macular vasculature after uncomplicated phacoemulsification surgery: Optical coherence tomography angiography study. J Cataract Refract Surg. 44:453–458. 2018.
28	Zhao YY, Chang PJ, Yu F and Zhao YE: Retinal vessel diameter changes induced by transient high perfusion pressure. Int J Ophthalmol. 7:602–607. 2014.
29	Fortune B, Choe TE, Reynaud J, Hardin C, Cull GA, Burgoyne CF and Wang L: Deformation of the rodent optic nerve head and peripapillary structures during acute intraocular pressure elevation. Invest Ophthalmol Vis Sci. 52:6651–6661. 2011.
30	Saygili O, Mete A, Mete A, Gungor K, Bekir N and Bayram M: Does phacoemulsification under topical anesthesia affect retrobulbar blood flow? J Clin Ultrasound. 40:572–575. 2012.
31	Lam DS, Leung KS, Mohamed S, Chan WM, Palanivelu MS, Cheung CY, Li EY, Lai RY and Leung CK: Regional variations in the relationship between macular thickness measurements and myopia. Invest Ophthalmol Vis Sci. 48:376–382. 2007.