![Open Access](/resources/images/iconopenaccess.png)
Mitochondrial dysfunction and pancreatic islet β‑cell failure (Review)
- Authors:
- Wenxin Sha
- Fei Hu
- Shizhong Bu
-
Affiliations: Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China - Published online on: October 27, 2020 https://doi.org/10.3892/etm.2020.9396
- Article Number: 266
-
Copyright: © Sha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
![]() |
![]() |
![]() |
Schmidt AM: Highlighting diabetes mellitus: The epidemic continues. Arterioscler Thromb Vasc Biol. 38:e1–e8. 2018.PubMed/NCBI View Article : Google Scholar | |
Wang YJ, Schug J, Won KJ, Liu C, Naji A, Avrahami D, Golson ML and Kaestner KH: Single-cell transcriptomics of the human endocrine pancreas. Diabetes. 65:3028–3038. 2016.PubMed/NCBI View Article : Google Scholar | |
Lawlor N, George J, Bolisetty M, Kursawe R, Sun L, Sivakamasundari V, Kycia I, Robson P and Stitzel ML: Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes. Genome Res. 27:208–222. 2017.PubMed/NCBI View Article : Google Scholar | |
Huang Q, Bu S, Yu Y, Guo Z, Ghatnekar G, Bu M, Yang L, Lu B, Feng Z, Liu S and Wang F: Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase. Endocrinology. 148:81–91. 2007.PubMed/NCBI View Article : Google Scholar | |
International Diabetes Federation. IDF Diabetes Atlas, 8th edition. International Diabetes Federation, Brussels 2017. Available from: urihttp://www.diabetesatlas.orgsimplehttp://www.diabetesatlas.org. | |
Holman N, Young B and Gadsby R: Current prevalence of type 1 and type 2 diabetes in adults and children in the UK. Diabet Med. 32:1119–1120. 2015.PubMed/NCBI View Article : Google Scholar | |
Blake R and Trounce IA: Mitochondrial dysfunction and complications associated with diabetes. Biochim Biophys Acta. 1840:1404–1412. 2014.PubMed/NCBI View Article : Google Scholar | |
Ma RCW: Epidemiology of diabetes and diabetic complications in China. Diabetologia. 61:1249–1260. 2018.PubMed/NCBI View Article : Google Scholar | |
Ma ZA, Zhao Z and Turk J: Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus. Exp Diabetes Res. 2012(703538)2012.PubMed/NCBI View Article : Google Scholar | |
Montgomery MK: Mitochondrial dysfunction and diabetes: Is mitochondrial transfer a friend or foe? Biology (Basel). 8(33)2019.PubMed/NCBI View Article : Google Scholar | |
van der Bliek AM, Sedensky MM and Morgan PG: Cell biology of the mitochondrion. Genetics. 207:843–871. 2017.PubMed/NCBI View Article : Google Scholar | |
Henquin JC: Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes. 49:1751–1760. 2000.PubMed/NCBI View Article : Google Scholar | |
Komatsu M, Takei M, Ishii H and Sato Y: Glucose-stimulated insulin secretion: A newer perspective. J Diabetes Investig. 4:511–516. 2013.PubMed/NCBI View Article : Google Scholar | |
Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW and Shulman GI: Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metab. 5:253–264. 2007.PubMed/NCBI View Article : Google Scholar | |
Molnar MJ and Kovacs GG: Mitochondrial diseases. Handb Clin Neurol. 145:147–155. 2017.PubMed/NCBI View Article : Google Scholar | |
Fex M, Nicholas LM, Vishnu N, Medina A, Sharoyko VV, Nicholls DG, Spégel P and Mulder H: The pathogenetic role of β-cell mitochondria in type 2 diabetes. J Endocrinol. 236:R145–R159. 2018.PubMed/NCBI View Article : Google Scholar | |
O'Sullivan M, Rutland P, Lucas D, Ashton E, Hendricks S, Rahman S and Bitner-Glindzicz M: Mitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss. Hum Mol Genet. 24:1036–1044. 2015.PubMed/NCBI View Article : Google Scholar | |
Bohnsack MT and Sloan KE: The mitochondrial epitranscriptome: The roles of RNA modifications in mitochondrial translation and human disease. Cell Mol Life Sci. 75:241–260. 2018.PubMed/NCBI View Article : Google Scholar | |
Subramanian S, Kalyanaraman B and Migrino RQ: Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases. Recent Pat Cardiovasc Drug Discov. 5:54–65. 2010.PubMed/NCBI View Article : Google Scholar | |
Papa S, Martino PL, Capitanio G, Gaballo A, De Rasmo D, Signorile A and Petruzzella V: The oxidative phosphorylation system in mammalian mitochondria. Adv Exp Med Biol. 942:3–37. 2012.PubMed/NCBI View Article : Google Scholar | |
Conley KE: Mitochondria to motion: Optimizing oxidative phosphorylation to improve exercise performance. J Exp Biol. 219:243–249. 2016.PubMed/NCBI View Article : Google Scholar | |
Waypa GB, Smith KA and Schumacker PT: O2 sensing, mitochondria and ROS signaling: The fog is lifting. Mol Aspects Med. 47-48:76–89. 2016.PubMed/NCBI View Article : Google Scholar | |
Angelova PR and Abramov AY: Functional role of mitochondrial reactive oxygen species in physiology. Free Radic Biol Med. 100:81–85. 2016.PubMed/NCBI View Article : Google Scholar | |
Kausar S, Wang F and Cui H: The role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases. Cells. 7(274)2018.PubMed/NCBI View Article : Google Scholar | |
Akram M: Citric acid cycle and role of its intermediates in metabolism. Cell Biochem Biophys. 68:475–478. 2014.PubMed/NCBI View Article : Google Scholar | |
Chiabrando D, Mercurio S and Tolosano E: Heme and erythropoieis: More than a structural role. Haematologica. 99:973–983. 2014.PubMed/NCBI View Article : Google Scholar | |
Moreno-Navarrete JM, Rodríguez A, Ortega F, Becerril S, Girones J, Sabater-Masdeu M, Latorre J, Ricart W, Frühbeck G and Fernández-Real JM: Heme biosynthetic pathway is functionally linked to adipogenesis via mitochondrial respiratory activity. Obesity (Silver Spring). 25:1723–1733. 2017.PubMed/NCBI View Article : Google Scholar | |
Elustondo P, Martin LA and Karten B: Mitochondrial cholesterol import. Biochim Biophys Acta Mol Cell Biol Lipids. 1862:90–101. 2017.PubMed/NCBI View Article : Google Scholar | |
Martin LA, Kennedy BE and Karten B: Mitochondrial cholesterol: Mechanisms of import and effects on mitochondrial function. J Bioenerg Biomembr. 48:137–151. 2016.PubMed/NCBI View Article : Google Scholar | |
Bravo-Sagua R, Parra V, López-Crisosto C, Díaz P, Quest AF and Lavandero S: Calcium transport and signaling in mitochondria. Compr Physiol. 7:623–634. 2017.PubMed/NCBI View Article : Google Scholar | |
Wang C, Du J, Du S, Liu Y, Li D, Zhu X and Ni X: Endogenous H2S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice. Mol Cell Endocrinol. 474:65–73. 2018.PubMed/NCBI View Article : Google Scholar | |
Yan C, Duanmu X, Zeng L, Liu B and Song Z: Mitochondrial DNA: Distribution, mutations, and elimination. Cells. 8(379)2019.PubMed/NCBI View Article : Google Scholar | |
Roger AJ, Muñoz-Gómez SA and Kamikawa R: The origin and diversification of mitochondria. Curr Biol. 27:R1177–R1192. 2017.PubMed/NCBI View Article : Google Scholar | |
Stefano GB, Bjenning C, Wang F, Wang N and Kream RM: Mitochondrial heteroplasmy. Adv Exp Med Biol. 982:577–594. 2017.PubMed/NCBI View Article : Google Scholar | |
Saneto RP: Genetics of mitochondrial disease. Adv Genet. 98:63–116. 2017.PubMed/NCBI View Article : Google Scholar | |
Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, et al: Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci USA. 116:16028–16035. 2019.PubMed/NCBI View Article : Google Scholar | |
Cotney J, McKay SE and Shadel GS: Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. Hum Mol Genet. 18:2670–2682. 2009.PubMed/NCBI View Article : Google Scholar | |
Karasik A, Fierke CA and Koutmos M: Interplay between substrate recognition, 5'end tRNA processing and methylation activity of human mitochondrial RNase P. RNA. 25:1646–1660. 2019.PubMed/NCBI View Article : Google Scholar | |
Reinhard L, Sridhara S and Hallberg BM: The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria. Nucleic Acids Res. 45:12469–12480. 2017.PubMed/NCBI View Article : Google Scholar | |
Metodiev MD, Thompson K, Alston CL, Morris AAM, He L, Assouline Z, Rio M, Bahi-Buisson N, Pyle A, Griffin H, et al: Recessive mutations in TRMT10C cause defects in mitochondrial RNA processing and multiple respiratory chain deficiencies. Am J Hum Genet. 98:993–1000. 2016.PubMed/NCBI View Article : Google Scholar | |
Pearce SF, Rorbach J, Van Haute L, D'Souza AR, Rebelo-Guiomar P, Powell CA, Brierley I, Firth AE and Minczuk M: Maturation of selected human mitochondrial tRNAs requires deadenylation. Elife. 6(e27596)2017.PubMed/NCBI View Article : Google Scholar | |
Ricquier D: UCP1, the mitochondrial uncoupling protein of brown adipocyte: A personal contribution and a historical perspective. Biochimie. 134:3–8. 2017.PubMed/NCBI View Article : Google Scholar | |
Li Y, Maedler K, Shu L and Haataja L: UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS One. 3(e1397)2008.PubMed/NCBI View Article : Google Scholar | |
Pitt MA: Overexpression of uncoupling protein-2 in cancer: Metabolic and heat changes, inhibition and effects on drug resistance. Inflammopharmacology. 23:365–369. 2015.PubMed/NCBI View Article : Google Scholar | |
Chan SHH and Chan JYH: Mitochondria and reactive oxygen species contribute to neurogenic hypertension. Physiology (Bethesda). 32:308–321. 2017.PubMed/NCBI View Article : Google Scholar | |
Broche B, Ben Fradj S, Aguilar E, Sancerni T, Bénard M, Makaci F, Berthault C, Scharfmann R, Alves-Guerra MC and Duvillié B: Mitochondrial protein UCP2 controls pancreas development. Diabetes. 67:78–84. 2018.PubMed/NCBI View Article : Google Scholar | |
Oelkrug R, Polymeropoulos ET and Jastroch M: Brown adipose tissue: Physiological function and evolutionary significance. J Comp Physiol B. 185:587–606. 2015.PubMed/NCBI View Article : Google Scholar | |
Giralt M and Villarroya F: Mitochondrial uncoupling and the regulation of glucose homeostasis. Curr Diabetes Rev. 13:386–394. 2017.PubMed/NCBI View Article : Google Scholar | |
Hu M, Lin H, Yang L, Cheng Y and Zhang H: Interleukin-22 restored mitochondrial damage and impaired glucose-stimulated insulin secretion through down-regulation of uncoupling protein-2 in INS-1 cells. J Biochem. 161:433–439. 2017.PubMed/NCBI View Article : Google Scholar | |
Nanayakkara GK, Wang H and Yang X: Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation-A novel concept. Arch Biochem Biophys. 662:68–74. 2019.PubMed/NCBI View Article : Google Scholar | |
Rugarli E and Trifunovic A: Is mitochondrial free radical theory of aging getting old? Biochim Biophys Acta. 1847:1345–1346. 2015.PubMed/NCBI View Article : Google Scholar | |
Cheeseman KH and Slater TF: An introduction to free radical biochemistry. Br Med Bull. 49:481–493. 1993.PubMed/NCBI View Article : Google Scholar | |
Brieger K, Schiavone S, Miller FJ Jr and Krause KH: Reactive oxygen species: From health to disease. Swiss Med Wkly. 142(w13659)2012.PubMed/NCBI View Article : Google Scholar | |
He L, He T, Farrar S, Ji L, Liu T and Ma X: Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem. 44:532–553. 2017.PubMed/NCBI View Article : Google Scholar | |
Zorov DB, Juhaszova M and Sollott SJ: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 94:909–950. 2014.PubMed/NCBI View Article : Google Scholar | |
Vallabh NA, Romano V and Willoughby CE: Mitochondrial dysfunction and oxidative stress in corneal disease. Mitochondrion. 36:103–113. 2017.PubMed/NCBI View Article : Google Scholar | |
Panieri E and Santoro MM: ROS homeostasis and metabolism: A dangerous liason in cancer cells. Cell Death Dis. 7(e2253)2016.PubMed/NCBI View Article : Google Scholar | |
Loperena R and Harrison DG: Oxidative stress and hypertensive diseases. Med Clin North Am. 101:169–193. 2017.PubMed/NCBI View Article : Google Scholar | |
Rani V, Deep G, Singh RK, Palle K and Yadav UC: Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sci. 148:183–193. 2016.PubMed/NCBI View Article : Google Scholar | |
Gerber PA and Rutter GA: The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus. Antioxid Redox Signal. 26:501–518. 2017.PubMed/NCBI View Article : Google Scholar | |
Pramanik KC, Boreddy SR and Srivastava SK: Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS One. 6(e20151)2011.PubMed/NCBI View Article : Google Scholar | |
Sena LA and Chandel NS: Physiological roles of mitochondrial reactive oxygen species. Mol Cell. 48:158–167. 2012.PubMed/NCBI View Article : Google Scholar | |
Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC and Abel ED: Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes. 58:1986–1997. 2009.PubMed/NCBI View Article : Google Scholar | |
Makino A, Scott BT and Dillmann WH: Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia. 53:1783–1794. 2010.PubMed/NCBI View Article : Google Scholar | |
Broderick TL: ATP production and TCA activity are stimulated by propionyl-L-carnitine in the diabetic rat heart. Drugs R D. 9:83–91. 2008.PubMed/NCBI View Article : Google Scholar | |
Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, Del Prato S, Rabuazzo AM, Purrello F and Marchetti P: Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia. 48:282–289. 2005.PubMed/NCBI View Article : Google Scholar | |
Paradies G, Paradies V, Ruggiero FM and Petrosillo G: Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease. World J Gastroenterol. 20:14205–14218. 2014.PubMed/NCBI View Article : Google Scholar | |
Musatov A, Carroll CA, Liu YC, Henderson GI, Weintraub ST and Robinson NC: Identification of bovine heart cytochrome c oxidase subunits modified by the lipid peroxidation product 4-hydroxy-2-nonenal. Biochemistry. 41:8212–8220. 2002.PubMed/NCBI View Article : Google Scholar | |
Sinha K, Das J, Pal PB and Sil PC: Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol. 87:1157–1180. 2013.PubMed/NCBI View Article : Google Scholar | |
Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE and Shirihai OS: Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 58:2303–2315. 2009.PubMed/NCBI View Article : Google Scholar | |
Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, et al: Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest. 115:3587–3593. 2005.PubMed/NCBI View Article : Google Scholar | |
Petersen KF, Dufour S, Befroy D, Garcia R and Shulman GI: Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med. 350:664–671. 2004.PubMed/NCBI View Article : Google Scholar | |
Dan Dunn J, Alvarez LA, Zhang X and Soldati T: Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Redox Biol. 6:472–485. 2015.PubMed/NCBI View Article : Google Scholar | |
Kauppila TES, Kauppila JHK and Larsson NG: Mammalian mitochondria and aging: An update. Cell Metab. 25:57–71. 2017.PubMed/NCBI View Article : Google Scholar | |
Ye X, Sun X, Starovoytov V and Cai Q: Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains. Hum Mol Genet. 24:2938–2951. 2015.PubMed/NCBI View Article : Google Scholar | |
Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, Bohr VA and Fang EF: Mitophagy in neurodegeneration and aging. Neurochem Int. 109:202–209. 2017.PubMed/NCBI View Article : Google Scholar | |
Choi DS, Kim DK, Kim YK and Gho YS: Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics. 13:1554–1571. 2013.PubMed/NCBI View Article : Google Scholar | |
Alenquer M and Amorim MJ: Exosome biogenesis, regulation, and function in viral infection. Viruses. 7:5066–5083. 2015.PubMed/NCBI View Article : Google Scholar | |
Shakeri R, Kheirollahi A and Davoodi J: Apaf-1: Regulation and function in cell death. Biochimie. 135:111–125. 2017.PubMed/NCBI View Article : Google Scholar | |
Thorens B: GLUT2, glucose sensing and glucose homeostasis. Diabetologia. 58:221–232. 2015.PubMed/NCBI View Article : Google Scholar | |
Nicholls DG: The pancreatic β-cell: A bioenergetic perspective. Physiol Rev. 96:1385–1447. 2016.PubMed/NCBI View Article : Google Scholar | |
Ježek P and Dlasková A: Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic β-cells. Mitochondrion. 49:245–258. 2019.PubMed/NCBI View Article : Google Scholar | |
Mulder H: Transcribing β-cell mitochondria in health and disease. Mol Metab. 6:1040–1051. 2017.PubMed/NCBI View Article : Google Scholar | |
Kwak SH and Park KS: Role of mitochondrial DNA variation in the pathogenesis of diabetes mellitus. Front Biosci (Landmark Ed). 21:1151–1167. 2016.PubMed/NCBI View Article : Google Scholar | |
Jiang Z, Zhang Y, Yan J, Li F, Geng X, Lu H, Wei X, Feng Y, Wang C and Jia W: De novo mutation of m.3243A>G together with m.16093T>C associated with atypical clinical features in a pedigree with MIDD syndrome. J Diabetes Res. 2019(5184647)2019.PubMed/NCBI View Article : Google Scholar | |
Alves D, Calmeiro ME, Macário C and Silva R: Family phenotypic heterogeneity caused by mitochondrial DNA mutation A3243G. Acta Med Port. 30:581–585. 2017.PubMed/NCBI View Article : Google Scholar | |
El-Hattab AW, Emrick LT, Hsu JW, Chanprasert S, Jahoor F, Scaglia F and Craigen WJ: Glucose metabolism derangements in adults with the MELAS m.3243A>G mutation. Mitochondrion. 18:63–69. 2014.PubMed/NCBI View Article : Google Scholar | |
Meimaridou E, Goldsworthy M, Chortis V, Fragouli E, Foster PA, Arlt W, Cox R and Metherell LA: NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice. J Endocrinol. 236:13–28. 2018.PubMed/NCBI View Article : Google Scholar | |
Santos LRB, Muller C, de Souza AH, Takahashi HK, Spégel P, Sweet IR, Chae H, Mulder H and Jonas JC: NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells. Mol Metab. 6:535–547. 2017.PubMed/NCBI View Article : Google Scholar | |
Dutta P, Ma L, Ali Y, Sloot PMA and Zheng J: Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus. BMC Syst Biol. 13 (Suppl 2)(S36)2019.PubMed/NCBI View Article : Google Scholar | |
Tabebi M, Khabou B, Boukadi H, Ben Hamad M, Ben Rhouma B, Tounsi S, Maalej A, Kamoun H, Keskes-Ammar L, Abid M, et al: Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. 639:18–26. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhang J, Liu Y, Yang HW, Xu HY and Meng Y: Molecular mechanism of beta cell apoptosis induced by p58 in high glucose medium. Sheng Li Xue Bao. 61:379–385. 2009.(In Chinese). PubMed/NCBI | |
Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, et al: Antioxidants complement the requirement for protein chaperone function to maintain β-cell function and glucose homeostasis. Diabetes. 64:2892–2904. 2015.PubMed/NCBI View Article : Google Scholar | |
Vozza A, Parisi G, De Leonardis F, Lasorsa FM, Castegna A, Amorese D, Marmo R, Calcagnile VM, Palmieri L, Ricquier D, et al: UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation. Proc Natl Acad Sci USA. 111:960–965. 2014.PubMed/NCBI View Article : Google Scholar | |
Collins S, Pi J and Yehuda-Shnaidman E: Uncoupling and reactive oxygen species (ROS)-a double-edged sword for β-cell function? ‘Moderation in all things’. Best Pract Res Clin Endocrinol Metab. 26:753–758. 2012.PubMed/NCBI View Article : Google Scholar | |
Emre Y, Hurtaud C, Karaca M, Nubel T, Zavala F and Ricquier D: Role of uncoupling protein UCP2 in cell-mediated immunity: How macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes. Proc Natl Acad Sci USA. 104:19085–19090. 2007.PubMed/NCBI View Article : Google Scholar | |
Lee SC, Robson-Doucette CA and Wheeler MB: Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin. J Endocrinol. 203:33–43. 2009.PubMed/NCBI View Article : Google Scholar | |
Sharoyko VV, Abels M, Sun J, Nicholas LM, Mollet IG, Stamenkovic JA, Göhring I, Malmgren S, Storm P, Fadista J, et al: Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. Hum Mol Genet. 23:5733–5749. 2014.PubMed/NCBI View Article : Google Scholar | |
Nicholas LM, Valtat B, Medina A, Andersson L, Abels M, Mollet IG, Jain D, Eliasson L, Wierup N, Fex M and Mulder H: Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells. Mol Metab. 6:651–663. 2017.PubMed/NCBI View Article : Google Scholar | |
Baixauli F, López-Otín C and Mittelbrunn M: Exosomes and autophagy: Coordinated mechanisms for the maintenance of cellular fitness. Front Immunol. 5(403)2014.PubMed/NCBI View Article : Google Scholar | |
Wong SK, Chin KY, Suhaimi FH, Ahmad F and Ima-Nirwana S: The effects of a modified high-carbohydrate high-fat diet on metabolic syndrome parameters in male rats. Exp Clin Endocrinol Diabetes. 126:205–212. 2018.PubMed/NCBI View Article : Google Scholar | |
Rutter GA, Pullen TJ, Hodson DJ and Martinez-Sanchez A: Pancreatic β-cell identity, glucose sensing and the control of insulin secretion. Biochem J. 466:203–218. 2015.PubMed/NCBI View Article : Google Scholar | |
Newsholme P, Cruzat VF, Keane KN, Carlessi R and de Bittencourt PI Jr: Molecular mechanisms of ROS production and oxidative stress in diabetes. Biochem J. 473:4527–4550. 2016.PubMed/NCBI View Article : Google Scholar | |
Rehman K and Akash MSH: Mechanism of generation of oxidative stress and pathophysiology of type 2 diabetes mellitus: How are they interlinked? J Cell Biochem. 118:3577–3585. 2017.PubMed/NCBI View Article : Google Scholar | |
Rharass T, Lemcke H, Lantow M, Kuznetsov SA, Weiss DG and Panáková D: Ca2+-mediated mitochondrial reactive oxygen species metabolism augments Wnt/beta-catenin pathway activation to facilitate cell differentiation. J Biol Chem. 289:27937–27951. 2014.PubMed/NCBI View Article : Google Scholar | |
Sarre A, Gabrielli J, Vial G, Leverve XM and Assimacopoulos-Jeannet F: Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells. Free Radic Biol Med. 52:142–150. 2012.PubMed/NCBI View Article : Google Scholar | |
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M and Shimomura I: Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 114:1752–1761. 2004.PubMed/NCBI View Article : Google Scholar | |
Nowotny K, Jung T, Höhn A, Weber D and Grune T: Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules. 5:194–222. 2015.PubMed/NCBI View Article : Google Scholar | |
Turrens JF: Mitochondrial formation of reactive oxygen species. J Physiol. 552:335–344. 2003.PubMed/NCBI View Article : Google Scholar | |
Wang J and Wang H: Oxidative stress in pancreatic beta cell regeneration. Oxid Med Cell Longev. 2017(1930261)2017.PubMed/NCBI View Article : Google Scholar | |
Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renström E and Schuit FC: Redox control of exocytosis: Regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes. 54:2132–2142. 2005.PubMed/NCBI View Article : Google Scholar | |
Hopps E, Noto D, Caimi G and Averna MR: A novel component of the metabolic syndrome: The oxidative stress. Nutr Metab Cardiovasc Dis. 20:72–77. 2010.PubMed/NCBI View Article : Google Scholar | |
Rao R: Oxidative stress-induced disruption of epithelial and endothelial tight junctions. Front Biosci. 13:7210–7226. 2008.PubMed/NCBI View Article : Google Scholar | |
Newsholme P, Rebelato E, Abdulkader F, Krause M, Carpinelli A and Curi R: Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: A critical role for amino acids. J Endocrinol. 214:11–20. 2012.PubMed/NCBI View Article : Google Scholar | |
Fiorentino TV, Prioletta A, Zuo P and Folli F: Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des. 19:5695–5703. 2013.PubMed/NCBI View Article : Google Scholar | |
Koehler A and Van Noorden CJ: Reduced nicotinamide adenine dinucleotide phosphate and the higher incidence of pollution-induced liver cancer in female flounder. Environ Toxicol Chem. 22:2703–2710. 2003.PubMed/NCBI View Article : Google Scholar | |
Baldewpersad Tewarie NM, Burgers IA, Dawood Y, den Boon HC, den Brok MG, Klunder JH, Koopmans KB, Rademaker E, van den Broek HB, van den Bersselaar SM, et al: NADP+-dependent IDH1 R132 mutation and its relevance for glioma patient survival. Med Hypotheses. 80:728–731. 2013.PubMed/NCBI View Article : Google Scholar | |
Atai NA, Renkema-Mills NA, Bosman J, Schmidt N, Rijkeboer D, Tigchelaar W, Bosch KS, Troost D, Jonker A, Bleeker FE, et al: Differential activity of NADPH-producing dehydrogenases renders rodents unsuitable models to study IDH1R132 mutation effects in human glioblastoma. J Histochem Cytochem. 59:489–503. 2011.PubMed/NCBI View Article : Google Scholar | |
Pan HC, Lee CC, Chou KM, Lu SC and Sun CY: Serum levels of uncoupling proteins in patients with differential insulin resistance: A community-based cohort study. Medicine (Baltimore). 96(e8053)2017.PubMed/NCBI View Article : Google Scholar | |
Brondani LA, Assmann TS, Duarte GC, Gross JL, Canani LH and Crispim D: The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus. Arq Bras Endocrinol Metabol. 56:215–225. 2012.PubMed/NCBI View Article : Google Scholar | |
Oelkrug R, Goetze N, Meyer CW and Jastroch M: Antioxidant properties of UCP1 are evolutionarily conserved in mammals and buffer mitochondrial reactive oxygen species. Free Radic Biol Med. 77:210–216. 2014.PubMed/NCBI View Article : Google Scholar | |
Sreedhar A and Zhao Y: Uncoupling protein 2 and metabolic diseases. Mitochondrion. 34:135–140. 2017.PubMed/NCBI View Article : Google Scholar | |
Li N, Karaca M and Maechler P: Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity. Redox Biol. 13:541–549. 2017.PubMed/NCBI View Article : Google Scholar | |
Senese R, Valli V, Moreno M, Lombardi A, Busiello RA, Cioffi F, Silvestri E, Goglia F, Lanni A and de Lange P: Uncoupling protein 3 expression levels influence insulin sensitivity, fatty acid oxidation, and related signaling pathways. Pflugers Arch. 461:153–164. 2011.PubMed/NCBI View Article : Google Scholar | |
Edwards KS, Ashraf S, Lomax TM, Wiseman JM, Hall ME, Gava FN, Hall JE, Hosler JP and Harmancey R: Uncoupling protein 3 deficiency impairs myocardial fatty acid oxidation and contractile recovery following ischemia/reperfusion. Basic Res Cardiol. 113(47)2018.PubMed/NCBI View Article : Google Scholar | |
Chan CB and Harper ME: Uncoupling proteins: Role in insulin resistance and insulin insufficiency. Curr Diabetes Rev. 2:271–283. 2006.PubMed/NCBI View Article : Google Scholar | |
Jena NR: DNA damage by reactive species: Mechanisms, mutation and repair. J Biosci. 37:503–517. 2012.PubMed/NCBI View Article : Google Scholar | |
Borchert A, Kalms J, Roth SR, Rademacher M, Schmidt A, Holzhutter HG, Kuhn H and Scheerer P: Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction. Biochim Biophys Acta Mol Cell Biol Lipids. 1863:1095–1107. 2018.PubMed/NCBI View Article : Google Scholar | |
Jung CH and Choi KM: Impact of high-carbohydrate diet on metabolic parameters in patients with type 2 diabetes. Nutrients. 9(322)2017.PubMed/NCBI View Article : Google Scholar | |
Li C, Deng X, Xie X, Liu Y, Friedmann Angeli JP and Lai L: Activation of glutathione peroxidase 4 as a novel anti-inflammatory strategy. Front Pharmacol. 9(1120)2018.PubMed/NCBI View Article : Google Scholar | |
Lillig CH and Holmgren A: Thioredoxin and related molecules-from biology to health and disease. Antioxid Redox Signal. 9:25–47. 2007.PubMed/NCBI View Article : Google Scholar | |
Eguchi K and Nagai R: Islet inflammation in type 2 diabetes and physiology. J Clin Invest. 127:14–23. 2017.PubMed/NCBI View Article : Google Scholar | |
Margaryan S, Witkowicz A, Partyka A, Yepiskoposyan L, Manukyan G and Karabon L: The mRNA expression levels of uncoupling proteins 1 and 2 in mononuclear cells from patients with metabolic disorders: Obesity and type 2 diabetes mellitus. Postepy Hig Med Dosw (Online). 71:895–900. 2017.PubMed/NCBI View Article : Google Scholar | |
Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron-Wisnewsky J, Lacroix-Desmazes S, Bayry J, Kaveri SV, Clément K, et al: T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: Relevance to obesity and type 2 diabetes. Diabetes. 63:1966–1977. 2014.PubMed/NCBI View Article : Google Scholar | |
Oh H, Park SH, Kang MK, Kim YH, Lee EJ, Kim DY, Kim SI, Oh S, Lim SS and Kang YH: Asaronic acid attenuates macrophage activation toward M1 phenotype through inhibition of NF-κB pathway and JAK-STAT signaling in glucose-loaded murine macrophages. J Agric Food Chem, 2019. | |
Wang Y, Shan B, Liang Y, Wei H and Yuan J: Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1. Cell Death Dis. 9(732)2018.PubMed/NCBI View Article : Google Scholar | |
Kim DH, Lee JC, Kim S, Oh SH, Lee MK, Kim KW and Lee MS: Inhibition of autoimmune diabetes by TLR2 tolerance. J Immunol. 187:5211–5220. 2011.PubMed/NCBI View Article : Google Scholar | |
Tan Q, Majewska-Szczepanik M, Zhang X, Szczepanik M, Zhou Z, Wong FS and Wen L: IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice. Diabetes. 63:2761–2775. 2014.PubMed/NCBI View Article : Google Scholar | |
QiNan W, XiaGuang G, XiaoTian L, WuQuan D, Ling Z and Bing C: Par-4/NF-κB mediates the apoptosis of islet β cells induced by glucolipotoxicity. J Diabetes Res. 2016(4692478)2016.PubMed/NCBI View Article : Google Scholar | |
Cnop M, Toivonen S, Igoillo-Esteve M and Salpea P: Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells. Mol Metab. 6:1024–1039. 2017.PubMed/NCBI View Article : Google Scholar | |
Sauter NS, Thienel C, Plutino Y, Kampe K, Dror E, Traub S, Timper K, Bédat B, Pattou F, Kerr-Conte J, et al: Angiotensin II induces interleukin-1β-mediated islet inflammation and β-cell dysfunction independently of vasoconstrictive effects. Diabetes. 64:1273–1283. 2015.PubMed/NCBI View Article : Google Scholar | |
Dinarello CA, Donath MY and Mandrup-Poulsen T: Role of IL-1beta in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes. 17:314–321. 2010.PubMed/NCBI View Article : Google Scholar | |
Carrasco-Pozo C, Tan KN Gotteland M and Borges K: Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells function. Oxid Med Cell Longev. 2017(3839756)2017.PubMed/NCBI View Article : Google Scholar | |
Donath MY and Shoelson SE: Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 11:98–107. 2011.PubMed/NCBI View Article : Google Scholar | |
Gomes BF and Accardo CM: Immunoinflammatory mediators in the pathogenesis of diabetes mellitus. Einstein (Sao Paulo). 17(eRB4596)2019.PubMed/NCBI View Article : Google Scholar : (In En, Portuguese). |