Treatment and prognosis of COVID‑19: Current scenario and prospects (Review)
- Authors:
- Xuemei Li
- Tao Li
- Huihui Wang
-
Affiliations: Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China - Published online on: November 2, 2020 https://doi.org/10.3892/etm.2020.9435
- Article Number: 3
This article is mentioned in:
Abstract
Masters PS: The molecular biology of coronaviruses. Adv Virus Res. 66:193–292. 2006.PubMed/NCBI View Article : Google Scholar | |
Xu T, Chen C, Zhu Z, Cui M, Chen C, Dai H and Xue Y: Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19. Int J Infect Dis. 94:68–71. 2020.PubMed/NCBI View Article : Google Scholar | |
Wu C, Zhang Z, Mo Y, Wang D, Ning B, Xu P, Song J, Pei X, Ni X, Zheng Y, et al: Recommendations for control and prevention of infections for pediatric orthopedics during the epidemic period of COVID-19. World J Pediatr Surg. 3(e000124)2020.PubMed/NCBI View Article : Google Scholar | |
Ding J, Fu H, Liu Y, Gao J, Li Z, Zhao X, Zheng J, Sun W, Ni H, Ma X, et al: Prevention and control measures in radiology department for COVID-19. Eur Radiol. 30:3603–3608. 2020.PubMed/NCBI View Article : Google Scholar | |
Li X, Zai J, Zhao Q, Nie Q, Li Y, Foley BT and Chaillon A: Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2. J Med Virol. 92:602–611. 2020.PubMed/NCBI View Article : Google Scholar | |
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, et al: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 395:507–513. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579:270–273. 2020.PubMed/NCBI View Article : Google Scholar | |
Devaux CA, Rolain JM, Colson P and Raoult D: New insights on the antiviral effects of chloroquine against coronavirus: What to expect for COVID-19? Int J Antimicrob Agents. 55(105938)2020.PubMed/NCBI View Article : Google Scholar | |
Zheng J: SARS-CoV-2: An emerging coronavirus that causes a global threat. Int J Biol Sci. 16:1678–1685. 2020.PubMed/NCBI View Article : Google Scholar | |
Li X, Liu M, Zhao Q, Liu R, Zhang H, Dong M, Xu S, Liu J, Zhao H, Wei S, et al: Preliminary recommendations for lung surgery during COVID-19 epidemic period. Thorac Cancer. 11:1372–1374. 2020.PubMed/NCBI View Article : Google Scholar | |
Yang Y, Peng F, Wang R, Yange M, Guan K, Jiang T, Xu G, Sun J and Chang C: The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China. J Autoimmun. 109(102434)2020.PubMed/NCBI View Article : Google Scholar | |
Tang N, Li D, Wang X and Sun Z: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 18:844–847. 2020.PubMed/NCBI View Article : Google Scholar | |
Ge H, Wang X, Yuan X, Xiao G, Wang C, Deng T, Yuan Q and Xiao X: The epidemiology and clinical information about COVID-19. Eur J Clin Microbiol Infect Dis. 39:1011–1019. 2020.PubMed/NCBI View Article : Google Scholar | |
Suleyman G, Fadel RA, Malette KM, Hammond C, Abdulla H, Entz A, Demertzis Z, Hanna Z, Failla A, Dagher C, et al: Clinical characteristics and morbidity associated with coronavirus disease 2019 in a series of patients in metropolitan detroit. JAMA Netw Open. 3(e2012270)2020.PubMed/NCBI View Article : Google Scholar | |
National Health Commission of People's Republic of China. Diagnosis and treatment of pneumonia caused by novel coronavirus (trial version 7). | |
Huang Z, Zhuang D, Xiong B, Deng DX, Li H and Lai W: Occupational exposure to SARS-CoV-2 in burns treatment during the COVID-19 epidemic: Specific diagnosis and treatment protocol. Biomed Pharmacother. 127(110176)2020.PubMed/NCBI View Article : Google Scholar | |
Liu K, Fang YY, Deng Y, Liu W, Wang MF, M JP, Xiao W, Wang YN, Zhong MH, Li CH, et al: Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl). 133:1025–1031. 2020.PubMed/NCBI View Article : Google Scholar | |
Lo IL, Lio CF, Cheong HH, Lei CI, Cheong TH, Zhong X, Tian Y and Sin NN: Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau. Int J Biol Sci. 16:1698–1707. 2020.PubMed/NCBI View Article : Google Scholar | |
Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, Greninger AL, Pipavath S, Wurfel MM, Evans L, et al: Covid-19 in critically Ill patients in the seattle region-Case series. N Engl J Med. 382:2012–2022. 2020.PubMed/NCBI View Article : Google Scholar | |
Spiezia L, Boscolo A, Poletto F, Cerruti L, Tiberio I, Campello E, Navalesi P and Simioni P: COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost. 120:998–1000. 2020.PubMed/NCBI View Article : Google Scholar | |
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395:497–506. 2020.PubMed/NCBI View Article : Google Scholar | |
Interpretation of the diagnosis and treatment plan of corona virus disease 2019 (tentative fifth revised edition). Glob Health J 4: 6-8 2020. Published online 2020 Mar 17. doi: 10.1016/j.glohj.2020.03.002. | |
Li Y and Xia LM: Coronavirus disease 2019 (COVID-19): Role of chest CT in diagnosis and management. AJR Am J Roentgenol. 214:1280–1286. 2020.PubMed/NCBI View Article : Google Scholar | |
Yang WJ and Yan FH: Patients with RT-PCR-confirmed COVID-19 and normal chest CT. Radiology. 295(E3)2020.PubMed/NCBI View Article : Google Scholar | |
Tahamtan A and Ardebili A: Real-time RT-PCR in COVID-19 detection: Issues affecting the results. Expert Rev Mol Diagn. 20:453–454. 2020.PubMed/NCBI View Article : Google Scholar | |
Chan JF, Yip CC, To KK, Tang TH, Wong SC, Leung KH, Fung AY, Ng AC, Zou Z, Tsoi HW, et al: Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-PCR assay validated in vitro and with clinical specimens. J Clin Microbiol. 58:e00310–e00320. 2020.PubMed/NCBI View Article : Google Scholar | |
Tang YW, Schmitz JE, Persing DH and Stratton CW: Laboratory diagnosis of COVID-19: Current issues and challenges. J Clin Microbiol. 58:e00512–e00520. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Shen H, Wang X, Shi X, Li Y, Yan J, Chen Y and Gu B: Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients. Emerg Microbes Infect. 9:833–836. 2020.PubMed/NCBI View Article : Google Scholar | |
Jean SS, Lee PI and Hsueh PR: Treatment options for COVID-19: The reality and challenges. J Microbiol Immunol Infect. 53:436–443. 2020.PubMed/NCBI View Article : Google Scholar | |
Cortegiani A, Ippolito M, Ingoglia G, Iozzo P, Giarratano A and Einav S: Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19. J Crit Care. 59:176–190. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhai P, Ding YB, Wu X, Long JK, Zhong YJ and Li YM: The epidemiology, diagnosis and treatment of COVID-19. Int J Antimicrob Agents. 55(105955)2020.PubMed/NCBI View Article : Google Scholar | |
Ren JL, Zhang AH and Wang XJ: Traditional Chinese medicine for COVID-19 treatment. Pharmacol Res. 155(104743)2020.PubMed/NCBI View Article : Google Scholar | |
Taxonera C, Sagastagoitia I, Alba C, Mañas N, Olivares D and Rey E: 2019 novel coronavirus disease (COVID-19) in patients with inflammatory bowel diseases. Aliment Pharmacol Ther. 52:276–283. 2020.PubMed/NCBI View Article : Google Scholar | |
Russell CD, Millar JE and Baillie JK: Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 395:473–475. 2020.PubMed/NCBI View Article : Google Scholar | |
Goh KJ, Choong MC, Cheong EH, Kalimuddin S, Duu Wen S, Phua GC, Chan KS and Haja Mohideen S: Rapid progression to acute respiratory distress syndrome: Review of current understanding of critical illness from COVID-19 infection. Ann Acad Med Singap. 49:108–118. 2020.PubMed/NCBI | |
Zhan WQ, Li MD, Xu M and Lu YB: Successful treatment of COVID-19 using extracorporeal membrane oxygenation, a case report. Eur Rev Med Pharmacol Sci. 24:3385–3389. 2020.PubMed/NCBI View Article : Google Scholar | |
Solaimanzadeh I: Acetazolamide, nifedipine and phosphodiesterase inhibitors: Rationale for their utilization as adjunctive countermeasures in the treatment of coronavirus disease 2019 (COVID-19). Cureus. 12(e7343)2020.PubMed/NCBI View Article : Google Scholar | |
Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, van Buskirk C, Grossman BJ, Joyner M, Henderson JP, et al: Deployment of convalescent plasma for the prevention and treatment of COVID-19. J Clin Invest. 130:2757–2765. 2020.PubMed/NCBI View Article : Google Scholar | |
Malik YA: Properties of coronavirus and SARS-CoV-2. Malays J Pathol. 42:3–11. 2020.PubMed/NCBI | |
Hoffmann M, Hofmann-Winkler H and Pöhlmann S: Chapter 4 priming time: How cellular proteases arm coronavirus spike proteins. Springer Science and Business Media LLC, 2018. | |
Li F: Structure, function, and evolution of coronavirus spike proteins. Annu Rev Virol. 3:237–261. 2016.PubMed/NCBI View Article : Google Scholar | |
Li F: Receptor recognition mechanisms of coronaviruses: A decade of structural studies. J Virol. 89:1954–1964. 2015.PubMed/NCBI View Article : Google Scholar | |
Yi C, Sun X, Ye J, Ding L, Liu M, Yang Z, Lu X, Zhang Y, Ma L, Gu W, et al: Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol. 17:621–630. 2020.PubMed/NCBI View Article : Google Scholar | |
Ye Q, Wang B and Mao J: The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19. J Infect. 80:607–613. 2020.PubMed/NCBI View Article : Google Scholar | |
Guang C, Phillips RD, Jiang B and Milani F: Three key proteases-angiotensin-I-converting enzyme (ACE), ACE2 and renin-within and beyond the renin-angiotensin system. Arch Cardiovasc Dis. 105:373–385. 2012.PubMed/NCBI View Article : Google Scholar | |
Sanders JM, Monogue ML, Jodlowski TZ and Cutrell JB: Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A review. JAMA. 323(1824)2020.PubMed/NCBI View Article : Google Scholar | |
Cao Y, Liu Y, Shang J, Yuan Z, Ping F, Yao S, Guo Y and Li Y: Ang-(1-7) treatment attenuates lipopolysaccharide-induced early pulmonary fibrosis. Lab Invest. 99:1770–1783. 2019.PubMed/NCBI View Article : Google Scholar | |
Tan WSD, Liao W, Zhou S, Mei D and Wong WF: Targeting the renin-angiotensin system as novel therapeutic strategy for pulmonary diseases. Curr Opin Pharmacol. 40:9–17. 2018.PubMed/NCBI View Article : Google Scholar | |
Jia H: Pulmonary angiotensin-converting enzyme 2 (ACE2) and inflammatory lung disease. Shock. 46:239–248. 2016.PubMed/NCBI View Article : Google Scholar | |
Klein N, Gembardt F, Supé S, Kaestle SM, Nickles H, Erfinanda L, Lei X, Yin J, Wang L, Mertens M, et al: Angiotensin-(1-7) protects from experimental acute lung injury. Crit Care Med. 41:e334–e343. 2013.PubMed/NCBI View Article : Google Scholar | |
Nitulescu GM, Paunescu H, Moschos SA, Petrakis D, Nitulescu G, Ion GND, Spandidos DA, Nikolouzakis TK, Drakoulis N and Tsatsakis A: Comprehensive analysis of drugs to treat SARS-CoV-2 infection: Mechanistic insights into current COVID-19 therapies (Review). Int J Mol Med. 46:467–488. 2020.PubMed/NCBI View Article : Google Scholar | |
Sun ML, Yang JM, Sun YP and Su GH: Inhibitors of RAS might be a good choice for the therapy of COVID-19 pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 43:219–222. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese). | |
Zhang YM, Yu L, Tang L, Zhu M, Jin Y, Wang Z and Li L: A promising anti-cytokine-storm targeted therapy for COVID-19: The artificial-liver blood-purification system. Engineering (Beijing), March 20, 2020 (Online ahead of print). | |
Academician li lanjuan's team showed initial results in treating critically ill patients. urihttps://www.takefoto.cn/simplehttps://www.takefoto.cn/. | |
Yang XH, Sun RH, Zhao MY, Chen EZ, Liu J, Wang HL, Yang RL and Chen DC: Expert recommendations on blood purification treatment protocol for patients with severe COVID-19. Chronic Dis Transl Med. 6:106–114. 2020.PubMed/NCBI View Article : Google Scholar | |
Liguoro I, Pilotto C, Bonanni M, Ferrari ME, Pusiol A, Nocerino A, Vidal E and Cogo P: SARS-COV-2 infection in children and newborns: A systematic review. Eur J Pediatr. 179:1029–1046. 2020.PubMed/NCBI View Article : Google Scholar | |
Dehelean CA, Lazureanu V, Coricovac D, Mioc M, Oancea R, Marcovici I, Pinzaru I, Soica C, Tsatsakis AM and Cretu O: SARS-CoV-2: Repurposed drugs and novel therapeutic approaches-insights into chemical structure-biological activity and toxicological screening. J Clin Med. 9(2084)2020.PubMed/NCBI View Article : Google Scholar | |
Saxena SK (ed): Coronavirus disease 2019 (COVID-19). Springer Science and Business Media LLC, 2020. | |
Li H, Wang YM, Xu JY and Cao B: Potential antiviral therapeutics for 2019 novel coronavirus. Zhonghua Jie He He Hu Xi Za Zhi. 43:170–172. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese). | |
Lin L, Lu L, Cao W and Li T: Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 9:727–732. 2020.PubMed/NCBI View Article : Google Scholar | |
Song JC, Wang G, Zhang W, Zhang Y, Li WQ and Zhou Z: People's Liberation Army Professional Committee of Critical Care Medicine, Chinese Society on Thrombosis and Haemostasis. Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19. Mil Med Res. 7(19)2020.PubMed/NCBI View Article : Google Scholar | |
Baruah V and Bose S: Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV. J Med Virol. 92:495–500. 2020.PubMed/NCBI View Article : Google Scholar | |
Yang L, Tian D and Liu W: Strategies for vaccine development of COVID-19. Sheng Wu Gong Cheng Xue Bao. 36:593–604. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese). | |
Calina D, Docea AO, Petrakis D, Egorov AM, Ishmukhametov AA, Gabibov AG, Shtilman MI, Kostoff R, Carvalho F, Vinceti M, et al: Towards effective COVID-19 vaccines: Updates, perspectives and challenges. Int J Mol Med. 46:3–16. 2020.PubMed/NCBI View Article : Google Scholar | |
Thanh Le T, Andreadakis Z, Kumar A, Gómez Román R, Tollefsen S, Saville M and Mayhew S: The COVID-19 vaccine development landscape. Nat Rev Drug Discov. 19:305–306. 2020.PubMed/NCBI View Article : Google Scholar | |
Clinical Trials Arena Inovio commences Phase I trial of DNA vaccine for Covid-19. urihttps://www.clinicaltrialsarena.com/news/inovio-SARS-COV-2-vaccine-trial/simplehttps://www.clinicaltrialsarena.com/news/inovio-SARS-COV-2-vaccine-trial/. Accessed April 7, 2020. | |
Zhu L, Xu X, Ma K, Yang J, Guan H, Chen S, Chen Z and Chen G: Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression. Am J Transplant. 20:1859–1863. 2020.PubMed/NCBI View Article : Google Scholar | |
Qiao XM, Xu XF, Zi H, Liu GX, Li BH, Du X, Tian ZH, Liu XY, Luo LS and Wang X: Re-positive cases of nucleic acid tests in discharged patients with COVID-19: A follow-up study. Front Med (Lausanne). 7(349)2020.PubMed/NCBI View Article : Google Scholar | |
Zhang YH, Lin DJ, Xiao MF, Wang JC, Wei Y, Lei ZX, Zeng ZQ, Li L, Li HA and Xiang W: 2019-novel coronavirus infection in a three-month-old baby. Zhonghua Er Ke Za Zhi. 58(E006)2020.PubMed/NCBI View Article : Google Scholar : (In Chinese) (Online ahead of print). | |
Cecere TE, Todd SM and Leroith T: Regulatory T cells in arterivirus and coronavirus infections: Do they protect against disease or enhance it? Viruses. 4:833–846. 2012.PubMed/NCBI View Article : Google Scholar | |
Channappanavar R, Fett C, Zhao J, Meyerholz DK and Perlman S: Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. J Virol. 88:11034–11044. 2014.PubMed/NCBI View Article : Google Scholar | |
Chen J, Lau YF, Lamirande EW, Paddock CD, Bartlett JH, Zaki SR and Subbarao K: Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. J Virol. 84:1289–1301. 2010.PubMed/NCBI View Article : Google Scholar | |
Ng OW, Chia A, Tan AT, Jadi RS, Leong HN, Bertoletti A and Tan YJ: Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 34:2008–2014. 2016.PubMed/NCBI View Article : Google Scholar | |
Chen Z and John Wherry E: T cell responses in patients with COVID-19. Nat Rev Immunol. 20:529–536. 2020.PubMed/NCBI View Article : Google Scholar | |
Qu R, Ling Y, Zhang YH, Wei LY, Chen X, Li XM, Liu XY, Liu HM, Guo Z, Ren H and Wang Q: Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J Med Virol, March 17, 2020 (Online ahead of print). | |
Pannull F, Yenull T, Sun P, Gui S, Liang B, Li L, Zheng D, Wang J, Hesketh RL, Yang L and Zheng C: Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19). Radiology. 295:715–721. 2020.PubMed/NCBI View Article : Google Scholar | |
Pan F, Ye T, Sun P, Gui S, Liang B, Li L, Zheng D, Wang J, Hesketh RL, Yang L and Zheng C: Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology. 13(200370)2020.PubMed/NCBI View Article : Google Scholar | |
Lin X, Gong Z, Xiao Z, Xiong J, Fan B and Liu J: Novel coronavirus pneumonia outbreak in 2019: Computed tomographic findings in two cases. Korean J Radiol. 21:365–368. 2020.PubMed/NCBI View Article : Google Scholar | |
Li K, Wu J, Wu F, Guo D, Chen L, Fang Z and Li C: The clinical and chest CT features associated with severe and critical COVID-19 pneumonia. Invest Radiol. 55:327–331. 2020.PubMed/NCBI View Article : Google Scholar | |
Zhao M, Wang M, Zhang J, Ye J, Xu Y, Wang Z, Ye D, Liu J and Wan J: Advances in the relationship between coronavirus infection and cardiovascular diseases. Biomed Pharmacother. 127(110230)2020.PubMed/NCBI View Article : Google Scholar | |
Tadic M, Cuspidi C, Mancia G, Dell'Oro R and Grassi G: COVID-19, hypertension and cardiovascular diseases: Should we change the therapy? Pharmacol Res. 158(104906)2020.PubMed/NCBI View Article : Google Scholar | |
Wu J, Li W, Shi X, Chen Z, Jiang B, Liu J, Wang D, Liu C, Meng Y, Cui L, et al: Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19). J Intern Med. 288:128–138. 2020.PubMed/NCBI View Article : Google Scholar | |
Yin L, Mou H, Shao J, Zhu Y, Pang X, Yang J, Zhang J, Shi W, Yu S and Wang H: Correlation between Heart fatty acid binding protein and severe COVID-19: A case-control study. PLoS One. 15(e0231687)2020.PubMed/NCBI View Article : Google Scholar | |
Seitz R and Schramm W: DIC in COVID-19: Implications for prognosis and treatment? J Thromb Haemost. 18:1798–1799. 2020.PubMed/NCBI View Article : Google Scholar | |
Kostoff RN, Briggs MB, Porter AL, Aschner M, Spandidos DA and Tsatsakis A: [Editorial] COVID-19: Post-lockdown guidelines. Int J Mol Med. 46:463–466. 2020.PubMed/NCBI View Article : Google Scholar | |
Iddir M, Brito A, Dingeo G, Fernandez Del Campo SS, Samouda H, La Frano MR and Bohn T: Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the COVID-19 crisis. Nutrients. 12(1562)2020.PubMed/NCBI View Article : Google Scholar |