Long non‑coding RNA H19 regulates Bcl‑2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion

  • Authors:
    • Ru-Xia Bai
    • Zou-Ying Tang
  • View Affiliations

  • Published online on: November 17, 2020     https://doi.org/10.3892/etm.2020.9473
  • Article Number: 41
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Spontaneous abortion (SA) is the most frequently occurring pregnancy disorder and is a serious threat to women's health. Identifying novel risk factors and the molecular mechanisms underlying SA are important. The present study reported that the RNA expression levels of long non‑coding RNA H19 were lower in SA group compared with those in the control group, and the expression of Bax was increased and levels of Bcl‑2 and phospholipid hydroperoxide glutathione peroxidase (GPX4) were decreased in SA group at both the mRNA and protein levels. H19 expression was positively correlated with Bcl‑2 and GPX4 expression and negatively linked with Bax levels. It was demonstrated that silencing H19 downregulated Bcl‑2 and GPX4 expression and upregulated Bax expression at both the mRNA and protein levels in HTR‑8/SVneo trophoblast cells. In conclusion, the present findings suggested that H19 has important roles in SA by promoting apoptosis and ferroptosis.
View Figures
View References

Related Articles

Journal Cover

January-2021
Volume 21 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bai R and Tang Z: Long non‑coding RNA H19 regulates Bcl‑2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion. Exp Ther Med 21: 41, 2021.
APA
Bai, R., & Tang, Z. (2021). Long non‑coding RNA H19 regulates Bcl‑2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion. Experimental and Therapeutic Medicine, 21, 41. https://doi.org/10.3892/etm.2020.9473
MLA
Bai, R., Tang, Z."Long non‑coding RNA H19 regulates Bcl‑2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion". Experimental and Therapeutic Medicine 21.1 (2021): 41.
Chicago
Bai, R., Tang, Z."Long non‑coding RNA H19 regulates Bcl‑2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion". Experimental and Therapeutic Medicine 21, no. 1 (2021): 41. https://doi.org/10.3892/etm.2020.9473