Open Access

Adult-onset Still's disease and the role of dermatological manifestations: A case report and literature review

  • Authors:
    • Andrei Vâță
    • Ionela Adriana Vlăduțu
    • Carmen Manciuc
    • Cristina Lăcătusu
    • Alexandra Burlui
    • Anca Cardoneanu
    • Elena Rezuș
  • View Affiliations

  • Published online on: November 26, 2020     https://doi.org/10.3892/etm.2020.9515
  • Article Number: 85
  • Copyright: © Vâță et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adult‑onset Still's disease (AOSD) is a rare inflammatory systemic disease with unknown etiology, characterized by spiking fever, evanescent rash, arthralgia and arthritis, leukocytosis and possible multi‑organ involvement. Based on a case report of a 19‑year‑old man who was admitted to hospital for an influenza‑like syndrome associated with a transient and recurrent pale‑red disseminated non‑specific rash, we performed a PubMed database search for cases and reviews of Adult's Onset Still's Disease published in English in the last 5 years. Due to its heterogeneous clinical manifestations, of which skin rash is an important sign, and the lack of a specific laboratory test, the diagnosis requires the exclusion of a wide range of mimicking disorders and the use of specific scoring systems. The high ferritin levels, major leukocytosis with neutrophilia, absence of typical antibodies for other systemic autoimmune diseases and other markers of infectious disease were the milestones that led to the positive diagnosis. The first line of treatment remains corticosteroid therapy in association with disease‑modifying anti‑rheumatic drugs.
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January-2021
Volume 21 Issue 1

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Spandidos Publications style
Vâță A, Vlăduțu IA, Manciuc C, Lăcătusu C, Burlui A, Cardoneanu A and Rezuș E: Adult-onset Still's disease and the role of dermatological manifestations: A case report and literature review. Exp Ther Med 21: 85, 2021.
APA
Vâță, A., Vlăduțu, I.A., Manciuc, C., Lăcătusu, C., Burlui, A., Cardoneanu, A., & Rezuș, E. (2021). Adult-onset Still's disease and the role of dermatological manifestations: A case report and literature review. Experimental and Therapeutic Medicine, 21, 85. https://doi.org/10.3892/etm.2020.9515
MLA
Vâță, A., Vlăduțu, I. A., Manciuc, C., Lăcătusu, C., Burlui, A., Cardoneanu, A., Rezuș, E."Adult-onset Still's disease and the role of dermatological manifestations: A case report and literature review". Experimental and Therapeutic Medicine 21.1 (2021): 85.
Chicago
Vâță, A., Vlăduțu, I. A., Manciuc, C., Lăcătusu, C., Burlui, A., Cardoneanu, A., Rezuș, E."Adult-onset Still's disease and the role of dermatological manifestations: A case report and literature review". Experimental and Therapeutic Medicine 21, no. 1 (2021): 85. https://doi.org/10.3892/etm.2020.9515