Perspectives on skin disorder diagnosis among people living with HIV in southeastern Romania

Draganescu,Miruna; Baroiu,Liliana; Iancu,Alina; Dumitru,Caterina; Radaschin,Diana; Polea,Eduard Drima; Bobeica,Carmen; Tatu,Alin Laurentiu; Niculet,Elena; Fekete,Gyula Laszlo

doi:10.3892/etm.2020.9529

Perspectives on skin disorder diagnosis among people living with HIV in southeastern Romania

Authors:
- Miruna Draganescu
- Liliana Baroiu
- Alina Iancu
- Caterina Dumitru
- Diana Radaschin
- Eduard Drima Polea
- Carmen Bobeica
- Alin Laurentiu Tatu
- Elena Niculet
- Gyula Laszlo Fekete
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Affiliations: Department of Clinical Medicine, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, Galați 800010, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, Galați 800010, Romania, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, Galați 800010, Romania, Department of Demato‑Venereology, Doctoral School, ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iași 700115, Romania, Department of Dermatology, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, Târgu Mureș 540142, Romania
Published online on: November 26, 2020 https://doi.org/10.3892/etm.2020.9529
Article Number: 97

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Abstract

The beginnings of the human immunodeficiency virus (HIV) pandemic are closely linked to dermatological conditions. A large part of the population living with HIV (PLWH) has a series of skin conditions that determine at some point, a visit to the dermatologist. The introduction of highly active antiretroviral therapy (HAART) more than 20 years ago has diminished the range of dermatological conditions, with improved immunosuppression of CD4 lymphocytes. The study aimed to describe the prevalence of the diagnosed type of skin changes in PLWH receiving antiretroviral therapy and their stratification according to the degree of immunodeficiency. A prospective study was conducted on 57 PLWH evaluated monthly at an HIV outpatient clinic, from a tertiary hospital in southeastern Romania. Clinical examination and dermoscopy revealed the existence of a wide range of dermatological conditions; all 57 patients (100%) being diagnosed with one or more dermatological conditions. As our study shows, the prevalence of different dermatoses among PLWH varies depending on the geographical region. At the same time, under HAART, the image of dermatoses associated with decreased immunity from HIV infection has changed. The skin changes of PLWH no longer fully follow the classical staging, based on the degree of immunosuppression.

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