Open Access

Investigating the efficacy and safety of mineral smectite granules on wound healing

  • Authors:
    • Jiankun Wang
    • Min Wang
    • Lili Zhao
    • Li Liu
    • Xiang Wang
    • Zhining Fan
  • View Affiliations

  • Published online on: December 18, 2020     https://doi.org/10.3892/etm.2020.9591
  • Article Number: 160
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mineral smectite granules have traditionally been used for diarrhea and gastrointestinal bleeding; however, the wound healing ability of mineral smectite granules has not been investigated in detail. Therefore, the present study explored the efficacy and safety of mineral smectite granules on wound healing. An excision wound rat model was established. The experimental group was treated with smectite granules, the positive control group was treated with starch and the blank control group was left untreated. Wound closure rates, wound healing times and histopathological analysis were compared among the three groups. The mechanism underlying the effects of mineral smectite granules on wound healing was assessed by performing picrosirius red staining and immunohistochemical staining and measuring hydroxyproline content. Based on wound closure rates, wound healing times and histopathological analysis, the results indicated that rats treated with smectite granules displayed increased wound healing efficacy compared with the other two groups. Investigation of the underlying mechanism suggested that mineral smectite granules could promote wound healing by inducing collagen fiber synthesis and increasing the number of neovessels. The present study indicated the efficacy and safety of mineral smectite granules on wound healing and provided a theoretical basis for its application in a clinical setting.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Wang M, Zhao L, Liu L, Wang X and Fan Z: Investigating the efficacy and safety of mineral smectite granules on wound healing. Exp Ther Med 21: 160, 2021.
APA
Wang, J., Wang, M., Zhao, L., Liu, L., Wang, X., & Fan, Z. (2021). Investigating the efficacy and safety of mineral smectite granules on wound healing. Experimental and Therapeutic Medicine, 21, 160. https://doi.org/10.3892/etm.2020.9591
MLA
Wang, J., Wang, M., Zhao, L., Liu, L., Wang, X., Fan, Z."Investigating the efficacy and safety of mineral smectite granules on wound healing". Experimental and Therapeutic Medicine 21.2 (2021): 160.
Chicago
Wang, J., Wang, M., Zhao, L., Liu, L., Wang, X., Fan, Z."Investigating the efficacy and safety of mineral smectite granules on wound healing". Experimental and Therapeutic Medicine 21, no. 2 (2021): 160. https://doi.org/10.3892/etm.2020.9591