Open Access

MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3

  • Authors:
    • Jiehua Zhu
    • Jianglin Wang
    • Jialin Huang
    • Wensheng Du
    • Yingzhong He
    • Hongfei Pan
    • Junmin Luo
  • View Affiliations

  • Published online on: December 27, 2020     https://doi.org/10.3892/etm.2020.9602
  • Article Number: 171
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ectopic expression of microRNA (miRNA) in rheumatoid arthritis (RA) fibroblast‑like synoviocyte (RA FLS) is associated with the development of rheumatoid arthritis. The present study aimed to evaluate the effects of miRNA‑140‑5p (miR‑140) on the properties of RA FLSs. It was found that miR‑140 expression was decreased in 33 RA patients and extracted RA FLS samples, when compared to the corresponding healthy controls. Abnormally increased miR‑140 expression in RA FLSs attenuated cell proliferation and increased cell apoptosis. Additionally, reduced pro‑inflammatory cytokine production was observed in RA FLSs transfected with a miR‑140 precursor. Furthermore, the 3'‑UTR of the signal transducer and activator of transcription (STAT) 3 gene was identified as a target of miR‑140. Notably, restoration of STAT3 expression rescued the regulatory effect of miR‑140 on the proliferation, apoptosis and inflammatory cytokine production of RA FLSs. Therefore, the current findings indicated that miR‑140 is a crucial modulator of both proliferation and apoptosis, shedding light on the etiology behind RA FLS viability, which is modulated by an interplay between miR‑140 and STAT3 in the context of RA.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhu J, Wang J, Huang J, Du W, He Y, Pan H and Luo J: MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Exp Ther Med 21: 171, 2021
APA
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., & Luo, J. (2021). MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Experimental and Therapeutic Medicine, 21, 171. https://doi.org/10.3892/etm.2020.9602
MLA
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., Luo, J."MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3". Experimental and Therapeutic Medicine 21.2 (2021): 171.
Chicago
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., Luo, J."MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3". Experimental and Therapeutic Medicine 21, no. 2 (2021): 171. https://doi.org/10.3892/etm.2020.9602