Open Access

Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies

  • Authors:
    • Iuliana Sobaru Mohorea
    • Bogdan Socea
    • Dragoş Şerban
    • Zenaida Ceausu
    • Adrian Tulin
    • Violeta Melinte
    • Mihai Ceausu
  • View Affiliations

  • Published online on: April 14, 2021     https://doi.org/10.3892/etm.2021.10039
  • Article Number: 607
  • Copyright: © Mohorea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thyroid cancer accounts for 1% of all malignancies, and is becoming increasingly common worldwide. The literature reports a prevalence of ~50% of thyroid nodules detected during autopsies in subjects with unknown thyroid pathology. An extended retrospective study of 526 autopsy cases was performed to identify the prevalence of thyroid carcinoma, among various types of thyroid nodules identified incidentally. Tissue samples were taken from thyroid nodules, for investigation of the presence of thyroid carcinoma, along with their macroscopic and microscopic features by means of histopathology and immunohistochemistry (IHC) methods. Histopathological diagnosis of malignancy was found in 51 cases of analyzed thyroid samples. Systematic detailed studies demonstrated that a thyroid gland, apparently normal on macroscopic examination, may be the site of pathological manifestations, sometimes presenting carcinomatous findings. Among thyroid carcinomas, the highest frequency was that of papillary microcarcinomas, which have a long evolution, and are incidentally detected during autopsies. Papillary microcarcinoma is an extremely common incidental finding and the vast majority of these tumors pursue a benign course. Furthermore, it is therefore necessary to create national screening programs for the early detection of thyroid carcinoma.
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June-2021
Volume 21 Issue 6

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Spandidos Publications style
Mohorea IS, Socea B, Şerban D, Ceausu Z, Tulin A, Melinte V and Ceausu M: Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies. Exp Ther Med 21: 607, 2021.
APA
Mohorea, I.S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., & Ceausu, M. (2021). Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies. Experimental and Therapeutic Medicine, 21, 607. https://doi.org/10.3892/etm.2021.10039
MLA
Mohorea, I. S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., Ceausu, M."Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies". Experimental and Therapeutic Medicine 21.6 (2021): 607.
Chicago
Mohorea, I. S., Socea, B., Şerban, D., Ceausu, Z., Tulin, A., Melinte, V., Ceausu, M."Incidence of thyroid carcinomas in an extended retrospective study of 526 autopsies". Experimental and Therapeutic Medicine 21, no. 6 (2021): 607. https://doi.org/10.3892/etm.2021.10039