Long non‑coding RNA HIT000218960 is associated with poor prognosis in patients with gastric cancer

Dong,Kunbo; Bai,Li; Tong,Deyong; Shi,Xiuna; Wei,Sirong; Cai,Yongguo

doi:10.3892/etm.2021.10126

Long non‑coding RNA HIT000218960 is associated with poor prognosis in patients with gastric cancer

Authors:
- Kunbo Dong
- Li Bai
- Deyong Tong
- Xiuna Shi
- Sirong Wei
- Yongguo Cai
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Affiliations: Department of Gastroenterology, The 970th Hospital of the PLA joint Logistics Support Force, Yantai, Shandong 264001, P.R. China, Department of Oncology, The 970th Hospital of the PLA joint Logistics Support Force, Yantai, Shandong 264001, P.R. China, Department of Intervention, The 970th Hospital of the PLA joint Logistics Support Force, Yantai, Shandong 264001, P.R. China
Published online on: May 2, 2021 https://doi.org/10.3892/etm.2021.10126
Article Number: 694
Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) have been indicated to have important roles in the development of malignant tumors. In the present study, the expression of HIT000218960 in gastric cancer (GC) tissues was assessed and its clinical significance was analyzed. It was revealed that HIT000218960 was highly expressed in GC tissues and HIT000218960 levels in GC tissues from 103 cases were positively correlated with high mobility group AT‑hook 2 (HMGA2) mRNA expression. Furthermore, HIT000218960 was significantly associated with tumor diameter, TNM stage, histological grade, the number of lymph nodes with metastasis and HMGA2 expression in tumor tissues of patients with GC. The results of the univariate and multivariate Cox regression analysis indicated that HIT000218960 expression was a factor affecting the prognosis of patients with GC. In addition, patients with GC with lower HIT000218960 or HMGA2 expression had more favorable 3‑year survival, while HIT000218960 expression did not affect the 3‑year overall survival of patients with GC with different levels of HMGA2 expression. In conclusion, HIT000218960 was highly expressed in patients with GC and was related to poor prognosis.

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