Open Access

Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)

  • Authors:
    • Ioana Iancu
    • Adrian Bartoș
    • Cristian Liviu Cioltean
    • Caius Breazu
    • Cornel Iancu
    • Dana Bartoș
  • View Affiliations

  • Published online on: June 8, 2021     https://doi.org/10.3892/etm.2021.10285
  • Article Number: 853
  • Copyright: © Iancu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common and frequently diagnosed malignant tumor of the pancreas with few treatment options and poor life expectancy. Despite the advances in the surgical field, 40% of the patients are diagnosed with locally advanced disease which is not suitable for surgery. Radio‑frequency ablation (RFA) has been described as a new ‘weapon’ in the multimodal treatment of PDAC, representing a cytoreductive procedure which must be completed with radiotherapy or chemo‑radiotherapy. A systematic research was carried out utilizing the PubMed database in regards to this subject, to evaluate the role of RFA in PDAC management. Abstracts, letters‑to‑the‑editor and non‑English language manuscripts were excluded. The literature showed that RFA can be used in open and laparoscopic surgery but it is also feasible for endoscopic ultrasound (EUS‑guided RFA) or percutaneous approach. Even though we found optimistic and encouraging reports on overall survival (OS), randomized studies are still required to corroborate these findings. Our review research underline that surgical resection remains the only radical treatment option, RFA being a safe and feasible technique reserved for unresectable, non‑metastatic pancreatic tumors. Its combination with oncological treatment can improve the OS of these patients.
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August-2021
Volume 22 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Iancu I, Bartoș A, Cioltean CL, Breazu C, Iancu C and Bartoș D: Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review). Exp Ther Med 22: 853, 2021.
APA
Iancu, I., Bartoș, A., Cioltean, C.L., Breazu, C., Iancu, C., & Bartoș, D. (2021). Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review). Experimental and Therapeutic Medicine, 22, 853. https://doi.org/10.3892/etm.2021.10285
MLA
Iancu, I., Bartoș, A., Cioltean, C. L., Breazu, C., Iancu, C., Bartoș, D."Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 853.
Chicago
Iancu, I., Bartoș, A., Cioltean, C. L., Breazu, C., Iancu, C., Bartoș, D."Role of radio‑ablative technique for optimizing the survival of patients with locally advanced pancreatic adenocarcinoma (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 853. https://doi.org/10.3892/etm.2021.10285