Open Access

Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation

  • Authors:
    • Wei Liu
    • Kai Wang
    • Yan-Li Xiao
    • Chun Liu
    • Wei Gao
    • Dai-Hong Li
  • View Affiliations

  • Published online on: June 13, 2021     https://doi.org/10.3892/etm.2021.10299
  • Article Number: 867
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Donor‑specific human leukocyte antigen (HLA) antibodies (DSAs) have a significant role in graft survival after pediatric liver transplantation. To understand the significance of DSAs, a retrospective cohort study of 48 pediatric liver transplant recipients with posttransplant serum samples that were analyzed for DSAs was performed. According to their test results, the recipients were divided into a DSA‑positive group and a DSA‑negative group. Postoperative liver transplantation biopsies were performed in patients with abnormal liver function. The liver condition and prognosis of the recipients were recorded, and their association was analyzed. A total of 48 recipients were followed up for 2.7±0.8 years. DSA positivity was detected in 10 cases (20.8%). One case was positive for HLA class I and HLA class II antibodies, whereas 9 cases were positive for HLA class II antibodies, and the gene loci were HLA‑DR and/or DQ. Antibody‑mediated rejection (AMR) occurred in four of 10 patients in the DSA‑positive group. Liver function was abnormal in 3 of 38 cases in the DSA‑negative group. Multivariate analysis revealed that DSA positivity was an independent risk factor for liver insufficiency and long‑term survival of recipients. In addition, Kaplan‑Meier survival analysis demonstrated that there were significant differences in the survival of graft recipients between the DSA‑positive group and the DSA‑negative group (P<0.05). The positivity of DSAs after pediatric liver transplantation was closely related to the occurrence of AMR. These results suggested that DSAs should be routinely monitored post‑operatively, and that DSA‑positive recipients should be screened as soon as possible and given appropriate treatment.
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August-2021
Volume 22 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu W, Wang K, Xiao Y, Liu C, Gao W and Li D: Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation. Exp Ther Med 22: 867, 2021.
APA
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., & Li, D. (2021). Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation. Experimental and Therapeutic Medicine, 22, 867. https://doi.org/10.3892/etm.2021.10299
MLA
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., Li, D."Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation". Experimental and Therapeutic Medicine 22.2 (2021): 867.
Chicago
Liu, W., Wang, K., Xiao, Y., Liu, C., Gao, W., Li, D."Clinical relevance of donor‑specific human leukocyte antigen antibodies after pediatric liver transplantation". Experimental and Therapeutic Medicine 22, no. 2 (2021): 867. https://doi.org/10.3892/etm.2021.10299