Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)
- Authors:
- Zhidi Lin
- Feizhou Lu
- Xiaosheng Ma
- Xinlei Xia
- Fei Zou
- Jianyuan Jiang
-
Affiliations: Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China - Published online on: August 26, 2021 https://doi.org/10.3892/etm.2021.10655
- Article Number: 1221
-
Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Hartvigsen J, Hancock MJ, Kongsted A, Louw Q, Ferreira ML, Genevay S, Hoy D, Karppinen J, Pransky G, Sieper J, et al: What low back pain is and why we need to pay attention. Lancet. 391:2356–2367. 2018.PubMed/NCBI View Article : Google Scholar | |
Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S and Vos T: Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet. 396:2006–2017. 2021.PubMed/NCBI View Article : Google Scholar | |
Walker BF: The prevalence of low back pain: A systematic review of the literature from 1966 to 1998. J Spinal Disord. 13:205–217. 2000.PubMed/NCBI View Article : Google Scholar | |
Walker BF, Muller R and Grant WD: Low back pain in Australian adults: Prevalence and associated disability. J Manipulative Physiol Ther. 27:238–244. 2004.PubMed/NCBI View Article : Google Scholar | |
Vlaeyen JW, Maher CG, Wiech K, Van Zundert J, Meloto CB, Diatchenko L, Battie MC, Goossens M, Koes B and Linton SJ: Low back pain. Nat Rev Dis Primers. 4(52)2018.PubMed/NCBI View Article : Google Scholar | |
Wise CA, Sepich D, Ushiki A, Khanshour AM, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N and Solnica-Krezel L: The cartilage matrisome in adolescent idiopathic scoliosis. Bone Res. 8(13)2020.PubMed/NCBI View Article : Google Scholar | |
Adams MA and Roughley PJ: What is intervertebral disc degeneration, and what causes it? Spine (Phila Pa 1976). 31:2151–2161. 2006.PubMed/NCBI View Article : Google Scholar | |
Risbud MV and Shapiro IM: Role of cytokines in intervertebral disc degeneration: Pain and disc content. Nat Rev Rheumatol. 10:44–56. 2014.PubMed/NCBI View Article : Google Scholar | |
Chen LL: The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 21:475–490. 2020.PubMed/NCBI View Article : Google Scholar | |
Thomson DW and Dinger ME: Endogenous microRNA sponges: Evidence and controversy. Nat Rev Genet. 17:272–283. 2016.PubMed/NCBI View Article : Google Scholar | |
Shen S, Wu Y, Chen J, Xie Z, Huang K, Wang G, Yang Y, Ni W, Chen Z, Shi P, et al: CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. Ann Rheum Dis. 78:826–836. 2019.PubMed/NCBI View Article : Google Scholar | |
Cai Y, Liang R, Xiao S, Huang Q, Zhu D, Shi GP, Ouyang Q and Yang M: Circ_0088194 promotes the invasion and migration of rheumatoid arthritis fibroblast-like synoviocytes via the miR-766-3p/MMP2 axis. Front Immunol. 12(628654)2021.PubMed/NCBI View Article : Google Scholar | |
Han S, Kuang M, Sun C, Wang H, Wang D and Liu Q: Circular RNA hsa_circ_0076690 acts as a prognostic biomarker in osteoporosis and regulates osteogenic differentiation of hBMSCs via sponging miR-152. Aging (Albany NY). 12:15011–15020. 2020.PubMed/NCBI View Article : Google Scholar | |
Wu Y, Xie Z, Chen J, Chen J, Ni W, Ma Y, Huang K, Wang G, Wang J, Ma J, et al: Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression. Mol Cancer. 18(73)2019.PubMed/NCBI View Article : Google Scholar | |
Hao Y, Lu C, Zhang B, Xu Z, Guo H and Zhang G: CircPVT1 up-regulation attenuates steroid-induced osteonecrosis of the femoral head through regulating miR-21-5p-mediated Smad7/TGFβ signalling pathway. J Cell Mol Med. 25:4608–4622. 2021.PubMed/NCBI View Article : Google Scholar | |
Chen C, Tan H, Bi J, Li Z, Rong T, Lin Y, Sun L, Li X and Shen J: Identification of competing endogenous RNA regulatory networks in vitamin A deficiency-induced congenital scoliosis by transcriptome sequencing analysis. Cell Physiol Biochem. 48:2134–2146. 2018.PubMed/NCBI View Article : Google Scholar | |
Peng P, Zhang B, Huang J, Xing C, Liu W, Sun C, Guo W, Yao S, Ruan W, Ning G, et al: Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on pathogenesis and treatment of spinal cord injury. Life Sci. 257(118039)2020.PubMed/NCBI View Article : Google Scholar | |
Li Z, Chen X, Xu D, Li S, Chan MT and Wu WK: Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. 52(e12704)2019.PubMed/NCBI View Article : Google Scholar | |
Li Y, Zhou S, Peng P, Wang X, Du L, Huo Z and Xu B: Emerging role of circular RNA in intervertebral disc degeneration: Knowns and unknowns (Review). Mol Med Rep. 22:3057–3065. 2020.PubMed/NCBI View Article : Google Scholar | |
Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ and Hoyland JA: Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans. 35:652–655. 2007.PubMed/NCBI View Article : Google Scholar | |
Binch ALA, Shapiro IM and Risbud MV: Syndecan-4 in intervertebral disc and cartilage: Saint or synner? Matrix Biol. 52-54:355–362. 2016.PubMed/NCBI View Article : Google Scholar | |
Wang SZ, Rui YF, Lu J and Wang C: Cell and molecular biology of intervertebral disc degeneration: Current understanding and implications for potential therapeutic strategies. Cell Prolif. 47:381–390. 2014.PubMed/NCBI View Article : Google Scholar | |
Cheng X, Zhang L, Zhang K, Zhang G, Hu Y, Sun X, Zhao C, Li H, Li YM and Zhao J: Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein. Ann Rheum Dis. 77:770–779. 2018.PubMed/NCBI View Article : Google Scholar | |
Wang X, Wang B, Zou M, Li J, Lü G, Zhang Q, Liu F and Lu C: CircSEMA4B targets miR-431 modulating IL-1β-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. Biochim Biophys Acta Mol Basis Dis. 1864:3754–3768. 2018.PubMed/NCBI View Article : Google Scholar | |
Xie L, Huang W, Fang Z, Ding F, Zou F, Ma X, Tao J, Guo J, Xia X, Wang H, et al: CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis. Cell Death Dis. 10(751)2019.PubMed/NCBI View Article : Google Scholar | |
Guo W, Zhang B, Mu K, Feng SQ, Dong ZY, Ning GZ, Li HR, Liu S, Zhao L, Li Y, et al: Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk. Cell Death Dis. 9(319)2018.PubMed/NCBI View Article : Google Scholar | |
Guo W, Mu K, Zhang B, Sun C, Zhao L, Li HR, Dong ZY and Cui Q: The circular RNA circ-GRB10 participates in the molecular circuitry inhibiting human intervertebral disc degeneration. Cell Death Dis. 11(612)2020.PubMed/NCBI View Article : Google Scholar | |
Chen Z, Zhang W, Deng M, Li Y and Zhou Y: CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. Aging (Albany NY.). 12:21971–21991. 2020.PubMed/NCBI View Article : Google Scholar | |
Huang Y, Gao J, Wang J, Ye H, Yao T, Xu Y, Chen Z, Shen S and Ma J: Inhibition of intervertebral disc disease progression via the circPKNOX1-miR-370-3p-KIAA0355 axis. Cell Death Discov. 7(39)2021.PubMed/NCBI View Article : Google Scholar | |
Wang H, He P, Pan H, Long J, Wang J, Li Z, Liu H, Jiang W and Zheng Z: Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. Exp Mol Med. 50:1–14. 2018.PubMed/NCBI View Article : Google Scholar | |
Song J, Wang HL, Song KH, Ding ZW, Wang HL, Ma XS, Lu FZ, Xia XL, Wang YW, Fei-Zou and Jiang JY: CircularRNA_104670 plays a critical role in intervertebral disc degeneration by functioning as a ceRNA. Exp Mol Med. 50:1–12. 2018.PubMed/NCBI View Article : Google Scholar | |
Cui S and Zhang L: Circ_001653 silencing promotes the proliferation and ECM synthesis of NPCs in IDD by downregulating miR-486-3p-mediated CEMIP. Mol Ther Nucleic Acids. 20:385–399. 2020.PubMed/NCBI View Article : Google Scholar | |
Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, Wang K, Yang C and Zhang Y: CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 53(102679)2020.PubMed/NCBI View Article : Google Scholar | |
Guo W, Mu K, Zhang B, Sun C, Zhao L, Dong ZY and Cui Q: The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC. Cell Death Dis. 11(315)2020.PubMed/NCBI View Article : Google Scholar | |
Guo W, Zhang B, Sun C, Duan HQ, Liu WX, Mu K, Zhao L, Li HR, Dong ZY and Cui Q: Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-185-5p and matrix metalloproteinase 2. Int J Mol Med. 46:621–632. 2020.PubMed/NCBI View Article : Google Scholar | |
Xiao L, Ding B, Xu S, Gao J, Yang B, Wang J and Xu H: CircRNA_0058097 promotes tension-induced degeneration of endplate chondrocytes by regulating HDAC4 expression through sponge adsorption of miR-365a-5p. J Cell Biochem. 121:418–429. 2020.PubMed/NCBI View Article : Google Scholar | |
Song J, Chen ZH, Zheng CJ, Song KH, Xu GY, Xu S, Zou F, Ma XS, Wang HL and Jiang JY: Exosome-Transported circRNA_0000253 competitively adsorbs MicroRNA-141-5p and increases IDD. Mol Ther Nucleic Acids. 21:1087–1099. 2020.PubMed/NCBI View Article : Google Scholar | |
Ding F, Shao ZW and Xiong LM: Cell death in intervertebral disc degeneration. Apoptosis. 18:777–785. 2013.PubMed/NCBI View Article : Google Scholar | |
Zhao CQ, Jiang LS and Dai LY: Programmed cell death in intervertebral disc degeneration. Apoptosis. 11:2079–2088. 2006.PubMed/NCBI View Article : Google Scholar | |
Urban JP, Smith S and Fairbank JC: Nutrition of the intervertebral disc. Spine (Phila Pa 1976). 29:2700–2709. 2004.PubMed/NCBI View Article : Google Scholar | |
Grunhagen T, Wilde G, Soukane DM, Shirazi-Adl SA and Urban JP: Nutrient supply and intervertebral disc metabolism. J Bone Joint Surg Am. 88 (Suppl 2):S30–S35. 2006.PubMed/NCBI View Article : Google Scholar | |
Li Y, Pan D, Liu S, Xing X, Zhou H, Zhang B, Zhang D, Li B, Li G, Tao B, et al: Identification of circ-FAM169A sponges miR-583 involved in the regulation of intervertebral disc degeneration. J Orthop Translat. 26:121–131. 2020.PubMed/NCBI View Article : Google Scholar | |
Kahn M: Can we safely target the WNT pathway? Nat Rev Drug Discov. 13:513–532. 2014.PubMed/NCBI View Article : Google Scholar | |
Kong D, Gu R, Zhang C and Yin R: Knockdown of hsa_circ_0059955 induces apoptosis and cell cycle arrest in nucleus pulposus cells via inhibiting itchy E3 ubiquitin protein ligase. Drug Des Devel Ther. 14:3951–3963. 2020.PubMed/NCBI View Article : Google Scholar | |
Lyu FJ, Cui H, Pan H, Mc Cheung K, Cao X, Iatridis JC and Zheng Z: Painful intervertebral disc degeneration and inflammation: From laboratory evidence to clinical interventions. Bone Res. 9(7)2021.PubMed/NCBI View Article : Google Scholar | |
Wang Y, Che M, Xin J, Zheng Z, Li J and Zhang S: The role of IL-1beta and TNF-alpha in intervertebral disc degeneration. Biomed Pharmacother. 131(110660)2020.PubMed/NCBI View Article : Google Scholar | |
Miraghazadeh B and Cook MC: Nuclear factor-kappaB in autoimmunity: Man and Mouse. Front Immunol. 9(613)2018.PubMed/NCBI View Article : Google Scholar | |
Zhang GZ, Liu MQ, Chen HW, Wu ZL, Gao YC, Ma ZJ, He XG and Kang XW: NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. 54(e13057)2021.PubMed/NCBI View Article : Google Scholar | |
Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, et al: Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 5(4820)2014.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Yang B, Wang J, Cheng F, Shi K, Ying L, Wang C, Xia K, Huang X, Gong Z, et al: Cell senescence: A nonnegligible cell state under survival stress in pathology of intervertebral disc degeneration. Oxid Med Cell Longev. 2020(9503562)2020.PubMed/NCBI View Article : Google Scholar | |
Baker DJ and Petersen RC: Cellular senescence in brain aging and neurodegenerative diseases: Evidence and perspectives. J Clin Invest. 128:1208–1216. 2018.PubMed/NCBI View Article : Google Scholar | |
Grootaert MOJ, Moulis M, Roth L, Martinet W, Vindis C, Bennett MR and De Meyer GRY: Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis. Cardiovasc Res. 114:622–634. 2018.PubMed/NCBI View Article : Google Scholar | |
Lee S and Schmitt CA: The dynamic nature of senescence in cancer. Nat Cell Biol. 21:94–101. 2019.PubMed/NCBI View Article : Google Scholar | |
Wang F, Cai F, Shi R, Wang XH and Wu XT: Aging and age related stresses: A senescence mechanism of intervertebral disc degeneration. Osteoarthritis Cartilage. 24:398–408. 2016.PubMed/NCBI View Article : Google Scholar | |
Di Micco R, Krizhanovsky V, Baker D and d'Adda di Fagagna F: Cellular senescence in ageing: From mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol. 22:75–95. 2021.PubMed/NCBI View Article : Google Scholar | |
Youle RJ and Narendra DP: Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 12:9–14. 2011.PubMed/NCBI View Article : Google Scholar | |
Sun K, Jing X, Guo J, Yao X and Guo F: Mitophagy in degenerative joint diseases. Autophagy: Sep 24, 2020 (Epub ahead of print). doi: 10.1080/15548627.2020.1822097. | |
Doblado L, Lueck C, Rey C, Samhan-Arias AK, Prieto I, Stacchiotti A and Monsalve M: Mitophagy in human diseases. Int J Mol Sci. 22(3903)2021.PubMed/NCBI View Article : Google Scholar | |
Wang Y, Shen J, Chen Y, Liu H, Zhou H, Bai Z, Hu Z and Guo X: PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. Biochem Biophys Res Commun. 504:406–414. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhang Z, Xu T, Chen J, Shao Z, Wang K, Yan Y, Wu C, Lin J, Wang H, Gao W, et al: Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration. Cell Death Dis. 9(980)2018.PubMed/NCBI View Article : Google Scholar | |
Wang Y, Wang H, Zhuo Y, Hu Y, Zhang Z, Ye J, Liu L, Luo L, Zhao C, Zhou Q and Li P: SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy. Aging (Albany NY). 12:16126–16141. 2020.PubMed/NCBI View Article : Google Scholar | |
Lyu F, Zheng C, Wang H, Nie C, Ma X, Xia X, Zhu W, Jin X, Hu Y, Sun Y, et al: Establishment of a clinician-led guideline on the diagnosis and treatment of Hirayama disease using a modified Delphi technique. Clin Neurophysiol. 131:1311–1319. 2020.PubMed/NCBI View Article : Google Scholar | |
Wang XB, Wang H, Long HQ, Li DY and Zheng X: LINC00641 regulates autophagy and intervertebral disc degeneration by acting as a competitive endogenous RNA of miR-153-3p under nutrition deprivation stress. J Cell Physiol. 234:7115–7127. 2019.PubMed/NCBI View Article : Google Scholar | |
Dai S, Liang T, Shi X, Luo Z and Yang H: Salvianolic acid B protects intervertebral discs from oxidative stress-induced degeneration via activation of the JAK2/STAT3 signaling pathway. Oxid Med Cell Longev. 2021(6672978)2021.PubMed/NCBI View Article : Google Scholar | |
He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, et al: HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy. Autophagy: Jan 18, 2021 (Epub ahead of print). doi: 10.1080/15548627.2021.1872227. | |
Lan T, Shiyu-Hu Shen Z, Yan B and Chen J: New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs. Ageing Res Rev. 65(101227)2021.PubMed/NCBI View Article : Google Scholar | |
Yang RZ, Xu WN, Zheng HL, Zheng XF, Li B, Jiang LS and Jiang SD: Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis. J Cell Physiol. 236:2725–2739. 2021.PubMed/NCBI View Article : Google Scholar | |
Wang Y, Liu J, Ma J, Sun T, Zhou Q, Wang W, Wang G, Wu P, Wang H, Jiang L, et al: Exosomal circRNAs: Biogenesis, effect and application in human diseases. Mol Cancer. 18(116)2019.PubMed/NCBI View Article : Google Scholar | |
Seimiya T, Otsuka M, Iwata T, Shibata C, Tanaka E, Suzuki T and Koike K: Emerging roles of exosomal circular RNAs in cancer. Front Cell Dev Biol. 8(568366)2020.PubMed/NCBI View Article : Google Scholar |