IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media

Serban,Roxana; Filip,Cristiana; Radulescu,Luminita Mihaela; Badescu,Minerva Codruta; Badescu,Magda Mariana; Diaconescu,Bogdan Mihail; Cobzeanu,Mihail Dan; Cobzeanu,Bogdan Mihail

doi:10.3892/etm.2021.10660

IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media

Authors:
- Roxana Serban
- Cristiana Filip
- Luminita Mihaela Radulescu
- Minerva Codruta Badescu
- Magda Mariana Badescu
- Bogdan Mihail Diaconescu
- Mihail Dan Cobzeanu
- Bogdan Mihail Cobzeanu
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Affiliations: Department of Biochemistry, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Clinical Rehabilitation Hospital, 700656 Iasi, Romania, Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Physiopathology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Occupational Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Otorhinolaryngology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
Published online on: August 27, 2021 https://doi.org/10.3892/etm.2021.10660
Article Number: 1226
Copyright: © Serban et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL‑1α), interleukin 6 (IL‑6) and interleukin 8 (IL‑8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL‑6 and IL‑8 had the highest value in patients with CSOM and IL‑1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.

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