Open Access

Anticancer roles of let‑7f‑1‑3p in non‑small cell lung cancer via direct targeting of integrin β1

  • Authors:
    • Yanan Yang
    • Yuanrong Liu
    • Ning Xie
    • Liying Shao
    • Hang Sun
    • Yubo Wei
    • Yunxiao Sun
    • Pingyu Wang
    • Yunfei Yan
    • Shuyang Xie
    • Youjie Li
  • View Affiliations

  • Published online on: September 16, 2021     https://doi.org/10.3892/etm.2021.10740
  • Article Number: 1305
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is one of the most common types of cancer, with the highest mortality rate worldwide. MicroRNAs play notable roles in the chemotherapeutic effects of anticancer drugs. The present study used reverse transcription‑quantitative PCR, western blotting and cell migration and invasion assays to reveal the role of let‑7f‑1‑3p in non‑small cell lung cancer (NSCLC) and explore the effect of let‑7f‑1‑3p on doxorubicin (DOX) treatment. It was demonstrated that the levels of let‑7f‑1‑3p in carcinoma tissues were lower compared with those in paracarcinoma tissues. Thus, let‑7f‑1‑3p may act as a suppressor gene. The present study also explored the role of let‑7f‑1‑3p in A549 and NCI‑H1975 cells. Results revealed that let‑7f‑1‑3p could inhibit the viability, migration and invasion of NSCLC cells and induce their apoptosis. Integrin β1 acted as a target gene regulated by let‑7f‑1‑3p. This suggested that let‑7f‑1‑3p could enhance DOX‑inhibited cell viability, migration and invasion in vitro. Overall, the present study demonstrated that let‑7f‑1‑3p may act as a target for drug design and lung cancer therapy.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang Y, Liu Y, Xie N, Shao L, Sun H, Wei Y, Sun Y, Wang P, Yan Y, Xie S, Xie S, et al: Anticancer roles of let‑7f‑1‑3p in non‑small cell lung cancer via direct targeting of integrin β1. Exp Ther Med 22: 1305, 2021.
APA
Yang, Y., Liu, Y., Xie, N., Shao, L., Sun, H., Wei, Y. ... Li, Y. (2021). Anticancer roles of let‑7f‑1‑3p in non‑small cell lung cancer via direct targeting of integrin β1. Experimental and Therapeutic Medicine, 22, 1305. https://doi.org/10.3892/etm.2021.10740
MLA
Yang, Y., Liu, Y., Xie, N., Shao, L., Sun, H., Wei, Y., Sun, Y., Wang, P., Yan, Y., Xie, S., Li, Y."Anticancer roles of let‑7f‑1‑3p in non‑small cell lung cancer via direct targeting of integrin β1". Experimental and Therapeutic Medicine 22.5 (2021): 1305.
Chicago
Yang, Y., Liu, Y., Xie, N., Shao, L., Sun, H., Wei, Y., Sun, Y., Wang, P., Yan, Y., Xie, S., Li, Y."Anticancer roles of let‑7f‑1‑3p in non‑small cell lung cancer via direct targeting of integrin β1". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1305. https://doi.org/10.3892/etm.2021.10740